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OPENSEQ.org
DPO3B - DNA polymerase III subunit beta
UniProt: P0A988 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10242
Length: 366 (366)
Sequences: 1683
Seq/Len: 4.60
DPO3B
Paralog alert: 0.05 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
32_N 69_T 4.119 1.00
3_F 90_V 4.117 1.00
269_R 304_E 3.162 1.00
264_K 325_L 2.931 1.00
223_I 234_S 2.894 1.00
243_D 246_R 2.768 1.00
35_L 42_L 2.762 1.00
81_G 268_A 2.755 1.00
70_V 97_M 2.672 1.00
259_G 262_L 2.535 1.00
36_Q 67_A 2.502 1.00
129_T 213_P 2.45 1.00
270_A 302_A 2.417 1.00
146_M 197_R 2.402 1.00
255_H 339_M 2.207 1.00
2_K 91_Q 2.176 1.00
135_M 214_L 2.174 1.00
128_F 216_V 2.097 1.00
263_L 283_L 2.081 1.00
78_I 106_F 2.062 1.00
327_V 359_Y 2.047 1.00
41_T 56_R 2.042 1.00
257_E 335_N 2.026 1.00
154_Y 194_I 1.965 1.00
286_S 314_E 1.962 1.00
256_L 285_V 1.955 1.00
170_V 244_Y 1.953 1.00
172_T 242_P 1.95 1.00
35_L 75_F 1.927 1.00
37_V 59_L 1.895 1.00
289_Q 305_I 1.891 1.00
247_V 360_V 1.864 1.00
160_F 169_T 1.834 1.00
145_S 178_A 1.827 1.00
199_G 234_S 1.778 1.00
38_A 65_P 1.746 1.00
283_L 324_V 1.735 1.00
259_G 335_N 1.721 0.99
97_M 110_T 1.716 0.99
154_Y 239_G 1.705 0.99
255_H 337_R 1.692 0.99
38_A 41_T 1.691 0.99
166_E 181_S 1.689 0.99
291_K 303_E 1.688 0.99
194_I 237_V 1.684 0.99
141_A 180_C 1.663 0.99
138_L 169_T 1.657 0.99
266_A 292_I 1.635 0.99
73_R 77_D 1.619 0.99
318_G 366_L 1.606 0.99
328_L 336_V 1.6 0.99
284_Y 316_E 1.587 0.99
195_V 223_I 1.582 0.99
2_K 63_H 1.582 0.99
21_L 72_A 1.569 0.99
14_L 76_F 1.566 0.99
129_T 215_R 1.562 0.99
257_E 337_R 1.559 0.99
339_M 350_E 1.556 0.99
319_F 347_V 1.479 0.98
259_G 334_E 1.47 0.98
288_N 309_T 1.465 0.98
7_R 11_L 1.46 0.98
290_L 308_V 1.453 0.98
137_R 332_K 1.446 0.98
253_D 313_A 1.44 0.97
39_D 65_P 1.423 0.97
35_L 44_L 1.417 0.97
36_Q 43_S 1.412 0.97
145_S 171_A 1.408 0.97
37_V 61_Q 1.402 0.97
83_P 304_E 1.392 0.97
168_R 181_S 1.386 0.97
177_L 242_P 1.376 0.96
165_E 183_P 1.356 0.96
37_V 66_G 1.344 0.96
291_K 305_I 1.335 0.96
160_F 167_L 1.329 0.95
170_V 179_V 1.322 0.95
267_F 281_V 1.308 0.95
283_L 290_L 1.307 0.95
147_A 150_D 1.306 0.95
215_R 226_H 1.3 0.95
159_L 170_V 1.289 0.94
131_P 134_T 1.288 0.94
131_P 213_P 1.286 0.94
37_V 65_P 1.285 0.94
17_V 44_L 1.284 0.94
159_L 192_S 1.277 0.94
280_G 364_M 1.274 0.94
10_L 88_I 1.274 0.94
335_N 352_A 1.273 0.94
348_Q 360_V 1.273 0.94
106_F 302_A 1.272 0.94
254_K 310_Y 1.271 0.94
138_L 182_M 1.267 0.94
127_E 215_R 1.262 0.94
163_E 190_S 1.256 0.93
157_G 194_I 1.256 0.93
21_L 88_I 1.25 0.93
144_F 359_Y 1.248 0.93
199_G 232_F 1.243 0.93
83_P 269_R 1.241 0.93
166_E 183_P 1.237 0.93
194_I 239_G 1.236 0.93
157_G 237_V 1.235 0.93
161_E 245_R 1.23 0.92
153_Y 235_K 1.219 0.92
257_E 309_T 1.213 0.92
248_L 358_A 1.209 0.91
42_L 57_V 1.208 0.91
284_Y 291_K 1.206 0.91
78_I 273_L 1.201 0.91
177_L 249_P 1.198 0.91
281_V 321_V 1.196 0.91
241_F 244_Y 1.195 0.91
55_A 230_F 1.191 0.91
203_L 225_A 1.186 0.90
37_V 42_L 1.182 0.90
10_L 90_V 1.178 0.90
30_L 117_P 1.174 0.90
48_D 198_K 1.173 0.90
159_L 194_I 1.156 0.89
90_V 97_M 1.154 0.89
54_V 231_I 1.151 0.89
252_P 339_M 1.142 0.88
258_A 263_L 1.126 0.87
4_T 89_A 1.123 0.87
2_K 89_A 1.119 0.87
3_F 10_L 1.118 0.87
127_E 217_Q 1.115 0.86
143_Q 200_V 1.113 0.86
178_A 359_Y 1.111 0.86
176_R 323_Y 1.109 0.86
21_L 234_S 1.107 0.86
1_M 66_G 1.107 0.86
17_V 20_P 1.106 0.86
47_T 116_F 1.106 0.86
100_R 105_R 1.098 0.85
10_L 75_F 1.096 0.85
268_A 362_M 1.096 0.85
14_L 33_L 1.088 0.85
17_V 53_M 1.086 0.84
212_N 228_G 1.086 0.84
161_E 192_S 1.079 0.84
258_A 290_L 1.079 0.84
333_C 351_D 1.078 0.84
158_M 200_V 1.077 0.84
68_T 110_T 1.076 0.84
43_S 54_V 1.074 0.83
333_C 353_A 1.068 0.83
30_L 49_L 1.061 0.82
91_Q 100_R 1.06 0.82
6_E 85_G 1.053 0.82
260_C 331_L 1.052 0.82
320_N 323_Y 1.052 0.82
253_D 341_T 1.052 0.82
138_L 180_C 1.047 0.81
139_I 200_V 1.047 0.81
249_P 348_Q 1.041 0.81
47_T 52_E 1.04 0.81
152_R 174_G 1.04 0.81
60_V 63_H 1.037 0.80
310_Y 314_E 1.036 0.80
44_L 57_V 1.034 0.80
89_A 100_R 1.034 0.80
41_T 58_A 1.031 0.80
177_L 248_L 1.031 0.80
285_V 315_M 1.023 0.79
196_P 236_L 1.02 0.79
241_F 364_M 1.016 0.78
33_L 44_L 1.009 0.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4k3lA211000.016Contact Map0.848
1vpkA10.99181000.023Contact Map0.802
2avtA20.99731000.029Contact Map0.81
3p16A60.98631000.032Contact Map0.861
3t0pA20.98911000.035Contact Map0.851
3k4xA10.90711000.366Contact Map0.524
3ifvA30.61751000.556Contact Map0.564
1rwzA10.62021000.573Contact Map0.56
3aizA20.6121000.579Contact Map0.571
3lx2A30.61751000.58Contact Map0.606
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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