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OPENSEQ.org

PA1 - Phospholipase A1
UniProt: P0A921 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10738
Length: 289 (257)
Sequences: 302
Seq/Len: 1.18

PA1
Paralog alert: 0.02 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
249_Y 257_L 3.102 1.00
231_K 242_G 3.038 1.00
131_E 270_I 2.819 1.00
88_K 260_Q 2.809 1.00
242_G 262_Y 2.798 1.00
198_V 203_D 2.456 0.99
194_K 216_Q 2.437 0.99
159_G 179_Y 2.333 0.99
87_V 120_L 2.14 0.98
261_V 277_T 2.097 0.98
191_V 217_L 2.04 0.97
234_Y 239_G 2.026 0.97
161_N 179_Y 2.001 0.97
55_Y 94_A 1.98 0.96
108_L 140_L 1.973 0.96
116_S 132_T 1.882 0.95
263_S 275_N 1.88 0.95
226_A 247_L 1.859 0.94
160_Y 178_L 1.711 0.91
139_F 159_G 1.698 0.90
63_T 280_G 1.597 0.86
123_S 210_K 1.595 0.86
98_W 101_I 1.576 0.85
94_A 121_S 1.575 0.85
189_W 221_Y 1.563 0.84
244_E 260_Q 1.547 0.84
128_P 172_S 1.524 0.82
159_G 180_T 1.511 0.82
135_E 161_N 1.504 0.81
160_Y 176_N 1.483 0.80
52_L 285_L 1.476 0.79
158_M 180_T 1.47 0.79
159_G 258_Y 1.422 0.76
89_F 103_G 1.409 0.75
61_I 258_Y 1.401 0.74
151_W 189_W 1.38 0.73
133_N 167_R 1.372 0.72
139_F 179_Y 1.371 0.72
161_N 208_I 1.368 0.72
209_T 251_I 1.363 0.71
114_Q 134_Y 1.363 0.71
150_G 186_N 1.333 0.69
233_Q 242_G 1.324 0.68
111_S 137_Q 1.292 0.65
246_G 258_Y 1.287 0.65
246_G 260_Q 1.284 0.65
67_D 108_L 1.284 0.65
182_L 193_V 1.273 0.64
63_T 278_R 1.259 0.62
33_A 36_G 1.258 0.62
241_G 262_Y 1.256 0.62
106_S 179_Y 1.255 0.62
212_M 242_G 1.235 0.60
55_Y 151_W 1.223 0.59
86_E 119_Q 1.222 0.59
204_D 271_D 1.216 0.58
34_V 37_S 1.216 0.58
261_V 279_V 1.206 0.58
246_G 284_M 1.205 0.57
38_I 42_M 1.202 0.57
207_D 273_N 1.194 0.56
178_L 197_Y 1.192 0.56
105_N 112_Y 1.183 0.55
216_Q 275_N 1.18 0.55
42_M 109_G 1.18 0.55
106_S 142_F 1.175 0.55
258_Y 280_G 1.171 0.54
232_G 236_W 1.166 0.54
263_S 277_T 1.162 0.53
117_W 278_R 1.162 0.53
163_D 198_V 1.159 0.53
91_L 152_T 1.158 0.53
216_Q 233_Q 1.155 0.53
69_N 271_D 1.153 0.52
52_L 97_L 1.149 0.52
138_L 160_Y 1.143 0.51
120_L 160_Y 1.139 0.51
228_L 247_L 1.137 0.51
163_D 255_V 1.132 0.50
61_I 280_G 1.123 0.50
96_P 107_V 1.123 0.50
189_W 193_V 1.12 0.49
41_N 48_N 1.117 0.49
251_I 257_L 1.115 0.49
52_L 231_K 1.102 0.48
39_I 44_Q 1.094 0.47
230_A 245_L 1.093 0.47
172_S 204_D 1.092 0.47
114_Q 153_L 1.091 0.46
45_E 51_T 1.089 0.46
230_A 243_A 1.081 0.45
80_E 124_E 1.073 0.45
33_A 40_A 1.067 0.44
35_R 111_S 1.064 0.44
56_D 137_Q 1.056 0.43
193_V 233_Q 1.052 0.43
58_N 204_D 1.047 0.42
57_T 288_L 1.045 0.42
210_K 238_T 1.043 0.42
158_M 189_W 1.04 0.42
214_Y 244_E 1.034 0.41
198_V 268_S 1.032 0.41
119_Q 280_G 1.027 0.40
102_L 108_L 1.026 0.40
120_L 202_T 1.026 0.40
153_L 191_V 1.025 0.40
188_N 243_A 1.024 0.40
124_E 163_D 1.024 0.40
87_V 97_L 1.016 0.39
214_Y 236_W 1.014 0.39
276_Q 280_G 1.014 0.39
228_L 257_L 1.01 0.39
50_F 176_N 1.009 0.39
94_A 250_P 1.003 0.38
250_P 257_L 1.002 0.38
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1qd5A10.95161000.082Contact Map0.494
1qd6C20.83041000.126Contact Map0.53
4e1sA10.522519.70.972Contact Map0.217
4e1tA10.52615.90.974Contact Map0.175
2o4vA30.366850.979Contact Map0.25
2x9kA10.60212.50.982Contact Map0.409
2pjvA10.04151.50.984Contact Map
2f1vA60.35641.20.985Contact Map0.514
4fqeA10.44291.20.985Contact Map0.535
2ariA10.0451.10.985Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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