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OPENSEQ.org
OMPW - Outer membrane protein W
UniProt: P0A915 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11124
Length: 212 (212)
Sequences: 562
Seq/Len: 2.65
OMPW
Paralog alert: 0.12 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
76_L 104_L 4.262 1.00
121_V 159_V 3.109 1.00
117_F 163_Y 2.969 1.00
117_F 161_V 2.88 1.00
170_L 209_G 2.624 1.00
165_I 171_V 2.603 1.00
86_I 97_V 2.464 1.00
166_N 169_W 2.289 1.00
103_T 156_A 1.913 0.99
54_V 199_L 1.89 0.99
169_W 210_Y 1.888 0.99
129_T 151_D 1.848 0.99
181_D 198_R 1.845 0.99
67_M 73_G 1.767 0.98
120_Y 172_N 1.731 0.98
69_T 72_I 1.724 0.98
34_A 205_M 1.721 0.98
68_A 74_V 1.674 0.98
111_G 118_R 1.648 0.97
27_F 66_Y 1.613 0.97
77_L 105_M 1.611 0.97
83_R 96_T 1.59 0.96
123_A 157_G 1.564 0.96
125_I 153_W 1.547 0.96
72_I 106_A 1.53 0.95
79_A 82_F 1.526 0.95
65_T 73_G 1.521 0.95
157_G 177_Y 1.513 0.95
27_F 64_F 1.499 0.95
80_T 131_F 1.485 0.94
30_R 120_Y 1.48 0.94
168_D 210_Y 1.478 0.94
120_Y 158_Q 1.47 0.94
116_K 163_Y 1.431 0.93
105_M 176_W 1.43 0.92
169_W 208_A 1.42 0.92
35_T 58_T 1.363 0.90
181_D 200_D 1.342 0.89
111_G 115_S 1.341 0.89
81_P 98_H 1.336 0.89
32_G 61_G 1.325 0.88
81_P 99_H 1.323 0.88
30_R 172_N 1.318 0.88
61_G 205_M 1.316 0.88
148_S 183_T 1.287 0.86
32_G 63_T 1.28 0.86
77_L 82_F 1.267 0.85
126_N 152_S 1.264 0.85
83_R 98_H 1.263 0.85
94_I 147_L 1.253 0.84
107_Q 176_W 1.234 0.83
65_T 107_Q 1.228 0.82
38_P 84_H 1.22 0.82
77_L 176_W 1.216 0.81
118_R 170_L 1.214 0.81
61_G 174_S 1.208 0.81
4_L 13_T 1.207 0.81
37_R 204_F 1.187 0.79
40_E 54_V 1.186 0.79
120_Y 209_G 1.182 0.79
37_R 56_N 1.176 0.78
67_M 118_R 1.174 0.78
162_D 172_N 1.174 0.78
102_P 126_N 1.162 0.77
176_W 205_M 1.154 0.77
85_K 93_D 1.152 0.76
59_Q 82_F 1.151 0.76
2_K 11_V 1.15 0.76
71_N 115_S 1.145 0.76
30_R 209_G 1.145 0.76
128_T 152_S 1.136 0.75
99_H 180_I 1.132 0.75
175_V 202_W 1.121 0.74
71_N 110_F 1.119 0.73
109_Y 174_S 1.109 0.72
98_H 132_D 1.106 0.72
97_V 149_L 1.099 0.71
183_T 196_S 1.094 0.71
77_L 99_H 1.086 0.70
58_T 72_I 1.085 0.70
96_T 150_K 1.083 0.70
146_D 187_K 1.077 0.69
82_F 99_H 1.075 0.69
32_G 81_P 1.072 0.69
5_T 10_A 1.066 0.68
2_K 8_A 1.059 0.67
32_G 82_F 1.059 0.67
179_D 200_D 1.059 0.67
30_R 162_D 1.046 0.66
59_Q 80_T 1.042 0.66
85_K 132_D 1.042 0.66
5_T 9_L 1.036 0.65
102_P 152_S 1.034 0.65
165_I 208_A 1.03 0.64
155_A 159_V 1.028 0.64
174_S 205_M 1.022 0.63
70_D 113_A 1.019 0.63
163_Y 166_N 1.016 0.63
136_N 139_G 1.01 0.62
39_T 177_Y 1.005 0.61
73_G 107_Q 1.002 0.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2f1vA60.90091000.365Contact Map0.68
2x27X10.91981000.496Contact Map0.744
2lhfA10.801999.90.679Contact Map0.381
2k0lA10.891599.80.711Contact Map0.353
3nb3A30.896299.80.713Contact Map0.572
3qraA10.731199.70.734Contact Map0.55
1qjpA10.797299.70.739Contact Map0.544
1p4tA10.731199.70.743Contact Map0.582
2jmmA10.688799.60.758Contact Map0.406
1ormA10.693499.60.761Contact Map0.186
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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