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OPENSEQ.org
YQIA - Esterase YqiA
UniProt: P0A8Z7 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12186
Length: 193 (189)
Sequences: 412
Seq/Len: 2.18
YQIA
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
76_T 159_Y 3.797 1.00
41_P 50_L 3.629 1.00
80_Q 139_I 2.721 1.00
7_L 51_L 2.586 1.00
140_W 165_T 2.136 1.00
141_L 164_Q 2.12 1.00
22_L 177_F 1.889 0.99
14_P 39_Q 1.87 0.98
171_N 175_T 1.806 0.98
145_T 168_E 1.76 0.98
52_E 81_C 1.734 0.97
11_N 115_Y 1.707 0.97
144_Q 176_G 1.649 0.96
144_Q 174_F 1.609 0.95
52_E 82_F 1.607 0.95
156_V 164_Q 1.574 0.94
105_Q 114_Q 1.571 0.94
123_Y 126_K 1.571 0.94
123_Y 127_V 1.551 0.94
5_L 65_I 1.527 0.93
6_Y 12_S 1.515 0.93
22_L 66_V 1.51 0.93
143_Q 155_A 1.492 0.92
23_K 35_M 1.473 0.91
107_E 114_Q 1.44 0.90
105_Q 116_V 1.395 0.88
89_V 142_L 1.393 0.88
36_I 54_I 1.383 0.88
80_Q 138_L 1.377 0.87
118_E 121_H 1.367 0.87
20_S 24_N 1.344 0.85
49_E 53_S 1.334 0.85
156_V 166_V 1.307 0.83
5_L 127_V 1.262 0.80
48_A 77_W 1.258 0.80
144_Q 155_A 1.25 0.79
86_A 150_L 1.249 0.79
85_P 138_L 1.249 0.79
52_E 56_L 1.243 0.79
64_G 188_L 1.238 0.78
140_W 180_Y 1.235 0.78
62_S 128_M 1.232 0.78
174_F 180_Y 1.226 0.77
124_D 128_M 1.217 0.77
19_A 37_I 1.21 0.76
4_L 64_G 1.207 0.76
65_I 84_L 1.196 0.75
144_Q 167_I 1.196 0.75
13_S 16_S 1.195 0.75
83_M 138_L 1.19 0.74
95_P 102_Y 1.187 0.74
94_R 97_E 1.169 0.72
170_G 174_F 1.168 0.72
98_L 154_Q 1.156 0.71
22_L 181_F 1.154 0.71
86_A 159_Y 1.151 0.71
145_T 169_G 1.149 0.71
144_Q 152_Y 1.147 0.70
48_A 55_V 1.135 0.69
122_I 166_V 1.131 0.69
89_V 174_F 1.128 0.69
44_P 90_N 1.108 0.67
152_Y 156_V 1.108 0.67
15_R 65_I 1.106 0.66
73_Y 96_F 1.102 0.66
149_V 184_I 1.101 0.66
74_Y 117_L 1.09 0.65
50_L 53_S 1.087 0.64
38_P 54_I 1.084 0.64
6_Y 16_S 1.083 0.64
85_P 135_A 1.082 0.64
80_Q 88_V 1.079 0.64
44_P 47_A 1.059 0.61
77_W 164_Q 1.056 0.61
28_E 46_D 1.054 0.61
12_S 18_K 1.051 0.61
26_L 165_T 1.051 0.61
79_S 139_I 1.044 0.60
4_L 190_L 1.038 0.59
54_I 112_G 1.03 0.58
23_K 27_A 1.03 0.58
117_L 144_Q 1.029 0.58
14_P 38_P 1.029 0.58
29_H 188_L 1.026 0.58
42_P 74_Y 1.022 0.57
76_T 86_A 1.013 0.56
108_N 111_T 1.012 0.56
3_T 61_D 1.01 0.56
33_V 185_V 1.009 0.56
7_L 11_N 1.007 0.56
117_L 152_Y 1.005 0.55
12_S 16_S 1.002 0.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4fleA111000.574Contact Map0.638
2qjwA40.813599.80.71Contact Map0.488
2wtmA40.984599.70.74Contact Map0.547
3llcA10.984599.70.741Contact Map0.5
1uxoA10.896499.60.748Contact Map0.427
3ksrA10.953499.60.752Contact Map0.454
3o4hA40.963799.60.754Contact Map0.361
3c6xA10.974199.60.756Contact Map0.471
4fblA40.963799.60.756Contact Map0.486
2qs9A20.896499.60.756Contact Map0.435
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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