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OPENSEQ.org

YCIA - Acyl-CoA thioester hydrolase YciA
UniProt: P0A8Z0 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11121
Length: 132 (125)
Sequences: 1379
Seq/Len: 11.03

YCIA
Paralog alert: 0.32 [within 20: 0.04] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
38_M 115_F 3.551 1.00
52_G 127_R 2.955 1.00
39_D 56_T 2.948 1.00
35_M 62_M 2.716 1.00
35_M 59_V 2.678 1.00
29_I 34_L 2.66 1.00
42_G 117_Y 2.62 1.00
85_T 128_A 2.504 1.00
22_D 33_W 2.231 1.00
30_F 36_S 2.195 1.00
23_T 70_V 2.188 1.00
82_Q 89_S 2.104 1.00
81_V 91_N 2.048 1.00
45_L 78_A 2.035 1.00
66_R 108_Y 1.896 1.00
50_A 88_V 1.868 1.00
10_G 49_I 1.781 1.00
75_C 107_R 1.72 1.00
18_A 29_I 1.716 1.00
33_W 36_S 1.683 1.00
16_T 40_I 1.682 1.00
48_E 97_K 1.671 1.00
121_D 125_K 1.584 1.00
72_D 98_K 1.578 1.00
109_K 112_E 1.531 1.00
68_V 110_A 1.523 1.00
60_E 114_L 1.486 1.00
45_L 80_C 1.393 0.99
93_E 109_K 1.373 0.99
68_V 74_V 1.372 0.99
72_D 108_Y 1.347 0.99
69_A 72_D 1.337 0.99
58_R 116_K 1.323 0.99
81_V 114_L 1.309 0.99
50_A 54_V 1.293 0.99
49_I 80_C 1.249 0.99
55_V 120_V 1.239 0.98
44_I 73_V 1.239 0.98
80_C 88_V 1.233 0.98
11_D 79_R 1.218 0.98
83_K 129_L 1.215 0.98
29_I 37_Q 1.211 0.98
43_A 47_K 1.177 0.98
24_N 30_F 1.173 0.98
81_V 89_S 1.167 0.97
86_T 126_P 1.147 0.97
46_A 54_V 1.141 0.97
24_N 31_G 1.14 0.97
26_N 120_V 1.138 0.97
89_S 114_L 1.117 0.96
60_E 89_S 1.101 0.96
91_N 114_L 1.099 0.96
92_I 115_F 1.085 0.96
33_W 37_Q 1.081 0.95
16_T 37_Q 1.073 0.95
96_V 108_Y 1.067 0.95
76_C 92_I 1.064 0.95
79_R 91_N 1.063 0.95
89_S 116_K 1.054 0.95
69_A 124_G 1.015 0.93
22_D 37_Q 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3b7kA30.97731000.36Contact Map0.719
2qq2A120.992499.90.451Contact Map0.857
1y7uA30.977399.90.455Contact Map0.793
4ienA40.969799.90.457Contact Map0.82
2q2bA20.977399.90.457Contact Map0.871
2gvhA30.977399.90.464Contact Map0.759
1vpmA30.977399.90.47Contact Map0.893
3bjkA6199.90.488Contact Map0.908
2v1oA60.886499.80.503Contact Map0.829
3d6lA10.962199.80.511Contact Map0.761

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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