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OPENSEQ.org
YCEI - Protein YceI
UniProt: P0A8X2 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11820
Length: 191 (188)
Sequences: 1593
Seq/Len: 8.47
YCEI
Paralog alert: 0.27 [within 20: 0.07] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
54_D 76_N 3.415 1.00
124_D 131_T 2.928 1.00
77_T 105_A 2.779 1.00
98_N 101_K 2.774 1.00
74_T 104_Q 2.75 1.00
126_T 131_T 2.633 1.00
53_K 81_D 2.611 1.00
98_N 128_N 2.574 1.00
72_N 108_T 2.451 1.00
26_K 190_Q 2.4 1.00
107_F 123_G 2.385 1.00
164_K 177_Q 2.302 1.00
162_K 177_Q 2.289 1.00
59_F 187_G 2.281 1.00
132_K 165_D 2.252 1.00
82_T 88_D 2.204 1.00
120_D 137_E 2.18 1.00
76_N 104_Q 2.168 1.00
121_I 138_A 2.099 1.00
110_T 124_D 2.091 1.00
162_K 165_D 2.069 1.00
90_H 95_D 2.005 1.00
77_T 99_T 1.995 1.00
120_D 135_T 1.989 1.00
122_T 133_P 1.946 1.00
108_T 124_D 1.93 1.00
86_E 89_K 1.892 1.00
65_N 68_A 1.875 1.00
113_K 120_D 1.827 1.00
85_A 89_K 1.826 1.00
125_L 134_V 1.817 1.00
160_K 178_E 1.785 1.00
136_L 157_A 1.78 1.00
157_A 183_I 1.746 1.00
71_V 109_S 1.702 1.00
34_A 185_V 1.7 1.00
122_T 135_T 1.641 1.00
94_A 98_N 1.627 1.00
58_T 72_N 1.6 1.00
112_V 121_I 1.521 1.00
124_D 133_P 1.502 1.00
146_D 152_R 1.497 1.00
27_I 57_G 1.483 1.00
156_E 184_S 1.483 1.00
24_D 60_T 1.478 1.00
40_I 175_A 1.469 0.99
77_T 97_L 1.435 0.99
75_I 105_A 1.435 0.99
161_I 181_L 1.419 0.99
102_Y 128_N 1.414 0.99
80_V 91_L 1.411 0.99
105_A 127_L 1.405 0.99
111_S 122_T 1.4 0.99
82_T 87_R 1.377 0.99
70_K 108_T 1.372 0.99
110_T 133_P 1.363 0.99
52_F 75_I 1.348 0.99
113_K 122_T 1.347 0.99
136_L 183_I 1.328 0.99
146_D 150_G 1.324 0.99
36_V 55_F 1.293 0.98
109_S 112_V 1.263 0.98
72_N 106_T 1.26 0.98
90_H 96_F 1.251 0.98
136_L 159_G 1.238 0.98
29_K 56_D 1.223 0.97
38_F 50_G 1.219 0.97
52_F 79_S 1.215 0.97
159_G 181_L 1.213 0.97
39_R 47_W 1.206 0.97
33_H 154_G 1.193 0.97
133_P 137_E 1.184 0.97
46_S 186_E 1.172 0.97
57_G 73_V 1.169 0.96
60_T 70_K 1.147 0.96
33_H 42_H 1.135 0.96
160_K 180_D 1.127 0.95
54_D 79_S 1.11 0.95
25_Y 187_G 1.107 0.95
73_V 183_I 1.105 0.95
48_L 87_R 1.088 0.94
27_I 185_V 1.085 0.94
146_D 149_G 1.084 0.94
152_R 186_E 1.072 0.94
128_N 168_I 1.072 0.94
28_D 33_H 1.071 0.93
102_Y 129_G 1.064 0.93
132_K 166_F 1.064 0.93
152_R 188_V 1.047 0.92
134_V 159_G 1.025 0.91
40_I 179_V 1.021 0.91
108_T 126_T 1.006 0.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1y0gA40.98951000.073Contact Map0.893
1wubA10.86911000.167Contact Map0.748
2fgsA10.87431000.176Contact Map0.711
3hpeA20.84291000.21Contact Map0.889
3q34A40.83771000.3Contact Map0.751
2x32A20.84291000.316Contact Map0.675
3nb3A30.78014.60.955Contact Map0.09
2vdaB10.10992.30.962Contact Map
3stbC10.7332.10.962Contact Map0.037
1tzsX10.12041.70.964Contact Map
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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