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OPENSEQ.org
LFTR - Leucyl/phenylalanyl-tRNA--protein transferase
UniProt: P0A8P1 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11112
Length: 234 (228)
Sequences: 869
Seq/Len: 3.81
LFTR
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
94_A 97_Q 5.288 1.00
71_S 200_C 3.792 1.00
81_F 164_N 3.49 1.00
136_R 162_M 3.015 1.00
90_T 93_Y 2.985 1.00
100_E 117_V 2.932 1.00
77_S 80_R 2.799 1.00
96_G 121_H 2.598 1.00
177_F 182_G 2.488 1.00
39_L 128_H 2.474 1.00
75_S 196_S 2.371 1.00
89_V 168_T 2.339 1.00
72_L 174_C 2.293 1.00
16_P 208_L 2.162 1.00
75_S 197_L 2.11 1.00
120_Y 147_V 2.03 1.00
173_F 177_F 2.027 1.00
94_A 135_W 2.003 1.00
88_R 138_D 1.956 1.00
35_P 126_L 1.953 1.00
89_V 134_V 1.936 1.00
72_L 171_L 1.906 1.00
90_T 135_W 1.902 1.00
122_R 125_E 1.893 1.00
70_E 178_I 1.868 1.00
43_Q 149_Q 1.826 1.00
176_E 180_H 1.808 0.99
32_D 37_R 1.807 0.99
78_M 171_L 1.763 0.99
139_E 162_M 1.73 0.99
101_G 161_R 1.717 0.99
74_I 171_L 1.592 0.98
91_M 132_I 1.587 0.98
99_I 121_H 1.557 0.98
67_L 197_L 1.544 0.98
152_L 214_M 1.541 0.98
60_S 204_R 1.529 0.98
92_N 130_H 1.52 0.98
97_Q 101_G 1.517 0.98
190_L 201_E 1.516 0.98
38_L 119_A 1.51 0.97
146_G 153_F 1.467 0.97
95_F 129_A 1.463 0.97
5_Q 29_L 1.458 0.97
190_L 195_A 1.449 0.96
124_H 130_H 1.442 0.96
38_L 147_V 1.427 0.96
144_M 185_I 1.399 0.95
166_S 193_H 1.391 0.95
87_Y 162_M 1.378 0.95
132_I 144_M 1.376 0.95
69_P 174_C 1.372 0.95
171_L 197_L 1.372 0.95
174_C 178_I 1.368 0.95
124_H 131_S 1.356 0.94
90_T 134_V 1.35 0.94
66_V 184_L 1.346 0.94
87_Y 136_R 1.336 0.94
40_M 44_R 1.333 0.94
65_A 195_A 1.324 0.93
170_L 197_L 1.322 0.93
116_V 145_Y 1.297 0.92
151_T 183_K 1.293 0.92
65_A 190_L 1.285 0.92
124_H 129_A 1.282 0.92
104_S 161_R 1.279 0.92
41_A 58_W 1.258 0.91
100_E 114_R 1.255 0.91
87_Y 141_V 1.253 0.91
4_V 7_S 1.248 0.90
79_K 83_K 1.246 0.90
3_L 6_L 1.241 0.90
187_C 191_N 1.22 0.89
144_M 173_F 1.213 0.89
134_V 169_A 1.206 0.88
51_S 54_D 1.202 0.88
122_R 126_L 1.196 0.88
116_V 119_A 1.195 0.88
72_L 170_L 1.188 0.87
99_I 117_V 1.185 0.87
60_S 208_L 1.18 0.87
69_P 178_I 1.175 0.87
148_A 182_G 1.175 0.87
67_L 191_N 1.169 0.86
89_V 172_V 1.165 0.86
61_P 154_C 1.139 0.84
87_Y 168_T 1.134 0.84
34_S 37_R 1.12 0.83
66_V 200_C 1.118 0.83
96_G 100_E 1.116 0.82
82_H 171_L 1.113 0.82
61_P 204_R 1.1 0.81
149_Q 154_C 1.091 0.80
66_V 202_I 1.087 0.80
11_I 40_M 1.085 0.80
141_V 162_M 1.085 0.80
72_L 197_L 1.07 0.79
77_S 196_S 1.031 0.75
100_E 137_E 1.025 0.74
73_H 197_L 1.014 0.73
206_D 210_Y 1.008 0.73
50_F 115_G 1.007 0.72
65_A 191_N 1.003 0.72
202_I 210_Y 1.003 0.72
96_G 125_E 1 0.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2cxaA111000.059Contact Map0.741
2dxqA20.54730.20.967Contact Map0.263
4me7E20.290629.10.967Contact Map0.127
1zcoA20.423127.50.968Contact Map0.5
3gkrA10.927426.10.968Contact Map0.491
2o28A20.713721.70.969Contact Map0.307
3fynA10.662418.80.97Contact Map0.337
4lniA120.290616.20.971Contact Map0.646
2eamA10.282114.50.972Contact Map0.322
3i3gA20.619713.70.972Contact Map0.302
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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