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OPENSEQ.org
SYS - Serine--tRNA ligase
UniProt: P0A8L1 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10947
Length: 430 (424)
Sequences: 2063
Seq/Len: 4.87
SYS
Paralog alert: 0.07 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
408_Q 414_E 4.593 1.00
246_V 260_M 4.325 1.00
183_L 315_V 4.074 1.00
122_E 125_R 3.694 1.00
320_G 417_E 3.585 1.00
50_E 74_E 3.348 1.00
43_K 81_E 3.289 1.00
302_M 363_W 3.215 1.00
414_E 420_R 3.189 1.00
297_R 300_D 3.159 1.00
142_L 413_I 3.155 1.00
36_R 88_E 3.093 1.00
300_D 303_A 2.776 1.00
164_V 245_L 2.726 1.00
420_R 427_E 2.683 1.00
417_E 420_R 2.603 1.00
179_F 318_L 2.522 1.00
403_M 413_I 2.507 1.00
338_C 363_W 2.506 1.00
259_K 307_E 2.485 1.00
147_S 166_K 2.473 1.00
124_S 325_K 2.419 1.00
29_K 95_E 2.408 1.00
137_R 145_M 2.389 1.00
314_K 318_L 2.385 1.00
91_A 95_E 2.384 1.00
133_D 409_A 2.337 1.00
101_L 205_Y 2.315 1.00
153_A 249_E 2.296 1.00
124_S 313_E 2.246 1.00
182_D 422_Y 2.237 1.00
62_K 72_R 2.221 1.00
20_R 113_V 2.202 1.00
304_A 307_E 2.188 1.00
183_L 318_L 2.147 1.00
15_A 28_D 2.145 1.00
10_E 13_A 2.095 1.00
408_Q 412_R 2.088 1.00
126_W 317_Q 2.042 1.00
376_S 383_R 2.041 1.00
187_Q 318_L 2.024 1.00
294_Q 304_A 2.005 1.00
328_L 340_T 1.983 1.00
313_E 317_Q 1.983 1.00
108_A 302_M 1.982 1.00
113_V 330_T 1.94 1.00
47_L 78_L 1.934 1.00
32_A 36_R 1.929 1.00
375_R 382_T 1.897 1.00
203_T 247_R 1.89 1.00
193_N 245_L 1.885 1.00
201_Q 233_A 1.866 1.00
321_L 345_V 1.84 1.00
236_P 240_V 1.808 1.00
195_V 241_P 1.786 1.00
16_E 19_A 1.785 1.00
197_Y 267_F 1.784 1.00
128_T 131_E 1.756 1.00
314_K 317_Q 1.739 1.00
157_L 164_V 1.737 1.00
16_E 20_R 1.718 1.00
77_K 81_E 1.713 1.00
110_E 339_K 1.705 0.99
337_A 340_T 1.7 0.99
198_L 223_L 1.662 0.99
17_K 109_D 1.654 0.99
108_A 363_W 1.653 0.99
156_K 249_E 1.623 0.99
29_K 32_A 1.602 0.99
259_K 294_Q 1.597 0.99
94_A 98_D 1.597 0.99
242_L 362_V 1.583 0.99
297_R 374_C 1.566 0.99
43_K 46_N 1.561 0.99
73_L 77_K 1.549 0.99
40_L 89_L 1.545 0.99
8_R 34_E 1.541 0.99
168_Q 426_L 1.525 0.99
188_H 314_K 1.525 0.99
87_A 91_A 1.515 0.99
322_P 405_N 1.508 0.98
107_P 330_T 1.507 0.98
393_L 398_T 1.506 0.98
138_D 141_T 1.504 0.98
163_V 284_M 1.501 0.98
327_I 339_K 1.5 0.98
201_Q 214_A 1.495 0.98
57_S 60_Q 1.49 0.98
49_A 53_S 1.486 0.98
17_K 20_R 1.481 0.98
259_K 304_A 1.479 0.98
306_E 341_Y 1.478 0.98
84_A 88_E 1.478 0.98
148_G 169_I 1.474 0.98
153_A 245_L 1.472 0.98
115_K 119_D 1.45 0.98
80_E 84_A 1.432 0.98
107_P 333_M 1.432 0.98
423_M 426_L 1.429 0.98
143_G 149_L 1.424 0.98
406_Y 415_V 1.423 0.98
154_A 163_V 1.418 0.97
6_L 10_E 1.411 0.97
39_V 43_K 1.409 0.97
198_L 232_Y 1.408 0.97
69_E 73_L 1.407 0.97
6_L 13_A 1.4 0.97
119_D 329_C 1.396 0.97
253_E 297_R 1.384 0.97
317_Q 325_K 1.377 0.97
252_D 255_D 1.376 0.97
92_L 96_I 1.363 0.97
242_L 262_A 1.362 0.97
226_E 269_S 1.354 0.96
214_A 233_A 1.352 0.96
200_N 203_T 1.346 0.96
177_S 263_H 1.346 0.96
350_Q 354_R 1.337 0.96
53_S 57_S 1.334 0.96
301_S 386_H 1.334 0.96
74_E 77_K 1.333 0.96
124_S 317_Q 1.327 0.96
11_P 31_G 1.327 0.96
35_E 39_V 1.325 0.96
41_Q 45_E 1.319 0.96
320_G 406_Y 1.315 0.96
50_E 53_S 1.315 0.96
48_Q 86_K 1.314 0.96
202_D 247_R 1.313 0.96
173_H 288_D 1.313 0.96
325_K 343_L 1.309 0.95
79_G 83_D 1.292 0.95
246_V 295_I 1.28 0.95
171_R 182_D 1.279 0.95
327_I 333_M 1.269 0.94
415_V 428_Y 1.269 0.94
310_G 317_Q 1.267 0.94
69_E 72_R 1.267 0.94
414_E 428_Y 1.256 0.94
93_Q 97_R 1.253 0.94
138_D 349_A 1.248 0.94
219_H 233_A 1.233 0.93
301_S 361_N 1.23 0.93
108_A 111_V 1.228 0.93
54_R 75_V 1.219 0.93
158_T 232_Y 1.214 0.92
116_D 119_D 1.213 0.92
308_M 362_V 1.212 0.92
179_F 418_V 1.207 0.92
81_E 84_A 1.205 0.92
2_L 7_L 1.202 0.92
36_R 39_V 1.198 0.92
337_A 362_V 1.187 0.91
180_M 315_V 1.186 0.91
335_F 365_F 1.182 0.91
412_R 428_Y 1.179 0.91
250_I 373_R 1.179 0.91
98_D 102_T 1.176 0.91
317_Q 323_Y 1.172 0.91
17_K 107_P 1.168 0.90
302_M 338_C 1.166 0.90
294_Q 307_E 1.166 0.90
183_L 314_K 1.163 0.90
20_R 330_T 1.162 0.90
76_N 79_G 1.157 0.90
144_E 152_A 1.154 0.90
88_E 91_A 1.152 0.90
68_I 72_R 1.144 0.89
298_P 374_C 1.122 0.88
129_P 322_P 1.119 0.88
166_K 191_S 1.118 0.88
294_Q 311_H 1.117 0.88
201_Q 231_N 1.114 0.87
60_Q 64_R 1.105 0.87
194_Y 288_D 1.099 0.86
87_A 90_D 1.098 0.86
61_A 66_E 1.097 0.86
70_P 73_L 1.093 0.86
95_E 98_D 1.083 0.85
124_S 309_T 1.083 0.85
320_G 414_E 1.078 0.85
54_R 57_S 1.077 0.85
374_C 383_R 1.077 0.85
34_E 38_K 1.077 0.85
6_L 14_V 1.076 0.85
33_L 92_L 1.074 0.85
408_Q 428_Y 1.07 0.84
46_N 50_E 1.07 0.84
36_R 95_E 1.067 0.84
309_T 325_K 1.066 0.84
308_M 359_C 1.065 0.84
40_L 92_L 1.055 0.83
412_R 430_G 1.054 0.83
255_D 258_I 1.052 0.83
57_S 61_A 1.049 0.83
90_D 94_A 1.045 0.82
309_T 343_L 1.043 0.82
248_G 371_Q 1.037 0.82
183_L 188_H 1.032 0.81
56_K 59_G 1.031 0.81
250_I 375_R 1.028 0.81
12_D 16_E 1.027 0.81
302_M 305_L 1.025 0.81
13_A 16_E 1.02 0.80
83_D 86_K 1.017 0.80
359_C 390_G 1.017 0.80
376_S 379_D 1.006 0.79
61_A 71_L 1.003 0.79
141_T 144_E 1 0.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2dq0A20.98141000.257Contact Map0.752
1sesA20.96741000.258Contact Map0.765
2dq3A20.97911000.268Contact Map0.819
1wleA20.97911000.272Contact Map0.73
3lssA20.97911000.274Contact Map0.678
3vbbA60.98371000.283Contact Map0.774
3qneA10.98371000.298Contact Map0.674
3errA20.97211000.389Contact Map0.735
2cjaA20.94651000.545Contact Map0.458
3w3sA10.89771000.596Contact Map0.413
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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