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OPENSEQ.org
PSD - Phosphatidylserine decarboxylase proenzyme
UniProt: P0A8K1 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10775
Length: 322 (286)
Sequences: 783
Seq/Len: 2.74
PSD
Paralog alert: 0.03 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
89_A 146_V 3.789 1.00
61_R 65_E 3.337 1.00
53_Q 70_P 3.216 1.00
151_N 242_L 3.044 1.00
242_L 245_Q 2.977 1.00
54_K 59_S 2.951 1.00
91_G 136_T 2.94 1.00
130_N 262_P 2.61 1.00
195_P 261_A 2.107 1.00
87_M 277_T 2.067 1.00
188_L 197_A 2.041 1.00
155_R 190_D 1.906 0.99
89_A 136_T 1.906 0.99
42_V 57_T 1.899 0.99
31_G 34_T 1.863 0.99
71_L 75_V 1.842 0.99
55_P 60_Y 1.795 0.99
191_T 196_M 1.765 0.99
42_V 49_M 1.761 0.98
116_A 177_N 1.753 0.98
79_D 86_V 1.704 0.98
117_L 199_I 1.668 0.98
89_A 256_V 1.637 0.97
78_I 86_V 1.604 0.97
210_E 251_K 1.592 0.97
201_V 255_T 1.566 0.96
205_I 252_L 1.557 0.96
78_I 243_K 1.546 0.96
29_R 61_R 1.545 0.96
98_K 132_T 1.524 0.95
89_A 279_I 1.514 0.95
143_Y 147_H 1.485 0.94
145_R 246_E 1.48 0.94
15_K 204_T 1.472 0.94
11_Y 165_F 1.469 0.94
164_L 207_G 1.468 0.94
146_V 198_Q 1.462 0.94
126_D 129_R 1.457 0.94
166_S 169_H 1.45 0.94
127_L 261_A 1.449 0.93
24_W 28_K 1.421 0.93
110_H 176_P 1.402 0.92
146_V 200_L 1.401 0.92
153_I 190_D 1.39 0.92
53_Q 73_D 1.358 0.90
97_G 133_F 1.337 0.89
55_P 72_R 1.328 0.89
27_S 251_K 1.322 0.89
113_S 243_K 1.32 0.88
146_V 256_V 1.316 0.88
55_P 59_S 1.312 0.88
152_G 189_F 1.303 0.88
79_D 82_P 1.29 0.87
68_V 249_R 1.286 0.87
49_M 52_A 1.281 0.86
106_Q 178_L 1.262 0.85
48_D 51_E 1.261 0.85
23_G 251_K 1.234 0.83
79_D 282_P 1.233 0.83
214_A 217_I 1.231 0.83
127_L 188_L 1.227 0.83
261_A 264_K 1.224 0.83
156_E 227_R 1.224 0.83
135_T 257_I 1.214 0.82
93_I 134_V 1.21 0.82
23_G 27_S 1.21 0.82
172_A 179_F 1.209 0.82
198_Q 247_M 1.198 0.81
22_A 205_I 1.196 0.81
159_Y 183_E 1.193 0.81
271_L 275_S 1.187 0.80
85_L 265_V 1.185 0.80
151_N 192_E 1.174 0.79
23_G 204_T 1.168 0.79
58_A 279_I 1.164 0.78
137_Y 140_P 1.163 0.78
172_A 252_L 1.16 0.78
150_C 193_F 1.152 0.77
56_D 59_S 1.15 0.77
70_P 249_R 1.135 0.76
93_I 277_T 1.133 0.76
66_F 142_D 1.133 0.76
225_I 228_W 1.129 0.75
152_G 191_T 1.124 0.75
185_V 208_S 1.124 0.75
74_E 77_P 1.121 0.74
128_F 197_A 1.12 0.74
107_A 135_T 1.116 0.74
62_T 65_E 1.115 0.74
185_V 220_P 1.113 0.74
148_M 189_F 1.108 0.73
23_G 205_I 1.105 0.73
93_I 136_T 1.104 0.73
25_G 43_K 1.104 0.73
96_L 267_L 1.104 0.73
20_R 23_G 1.102 0.73
199_I 255_T 1.099 0.72
47_V 66_F 1.097 0.72
14_P 164_L 1.094 0.72
164_L 202_G 1.089 0.71
104_I 114_L 1.087 0.71
102_D 114_L 1.082 0.71
165_F 246_E 1.077 0.70
210_E 249_R 1.071 0.70
140_P 147_H 1.066 0.69
41_F 63_F 1.066 0.69
146_V 211_T 1.066 0.69
169_H 208_S 1.058 0.68
164_L 183_E 1.057 0.68
201_V 279_I 1.054 0.68
136_T 258_N 1.054 0.68
114_L 199_I 1.053 0.68
86_V 243_K 1.052 0.68
139_S 142_D 1.052 0.68
99_I 259_L 1.051 0.68
52_A 71_L 1.049 0.67
71_L 74_E 1.043 0.67
76_R 90_D 1.033 0.66
167_V 206_V 1.031 0.65
154_L 241_L 1.023 0.64
202_G 208_S 1.017 0.64
101_E 129_R 1.016 0.64
150_C 284_A 1.016 0.64
157_M 185_V 1.013 0.63
198_Q 258_N 1.011 0.63
192_E 274_L 1.009 0.63
92_V 142_D 1.009 0.63
10_Q 205_I 1.006 0.63
277_T 281_Q 1.005 0.62
214_A 219_P 1 0.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2gprA10.453491.80.951Contact Map0.575
2k7vA20.2609710.962Contact Map0.265
1f3zA10.47261.40.964Contact Map0.608
3ourB40.543555.10.966Contact Map0.628
1dczA10.23653.60.966Contact Map0.74
2dncA10.291951.70.966Contact Map0.782
2d5dA20.2267500.967Contact Map0.962
1bdoA10.245346.90.967Contact Map0.728
2kccA10.260942.60.968Contact Map0.158
1z6hA10.220540.10.969Contact Map0.898
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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