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OPENSEQ.org
YACG - DNA gyrase inhibitor YacG
UniProt: P0A8H8 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12314
Length: 65 (63)
Sequences: 341
Seq/Len: 5.41
YACG
Paralog alert: 0.00 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
30_K 33_Q 2.998 1.00
39_E 45_K 2.949 1.00
11_T 35_I 2.207 1.00
33_Q 41_A 1.799 1.00
16_V 22_S 1.732 1.00
6_T 15_T 1.703 1.00
34_L 45_K 1.576 0.99
34_L 37_L 1.572 0.99
19_G 23_P 1.547 0.99
31_R 37_L 1.495 0.99
43_E 46_R 1.461 0.98
15_T 20_E 1.449 0.98
34_L 39_E 1.402 0.98
55_E 61_E 1.345 0.97
7_V 16_V 1.314 0.96
35_I 38_G 1.28 0.96
18_W 34_L 1.235 0.94
50_S 53_L 1.15 0.91
1_M 63_P 1.099 0.88
55_E 59_W 1.094 0.88
22_S 39_E 1.09 0.88
8_N 15_T 1.088 0.88
57_D 60_S 1.087 0.88
7_V 41_A 1.082 0.87
17_V 22_S 1.077 0.87
17_V 21_I 1.046 0.85
18_W 25_R 1.044 0.85
58_D 61_E 1.031 0.84
24_F 44_E 1.029 0.84
58_D 62_E 1.027 0.83
18_W 41_A 1.015 0.82
2_S 5_I 1.006 0.82
1_M 52_D 1.004 0.81
20_E 61_E 1.004 0.81
55_E 60_S 1.001 0.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1lv3A1199.90.099Contact Map0.369
3i2dA10.7231550.858Contact Map0.096
1mtyD2146.50.865Contact Map0.341
3u52A20.953840.10.87Contact Map0.556
3ge3A10.938532.50.877Contact Map0.693
2incA10.969231.80.877Contact Map0.694
3vhsA20.417.30.891Contact Map0.4
3vhtB10.523112.60.898Contact Map0.327
4g9pA10.723111.40.9Contact Map0.04
3qwwA10.923110.80.901Contact Map0.727
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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