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OPENSEQ.org

EX7S - Exodeoxyribonuclease 7 small subunit
UniProt: P0A8G9 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11098
Length: 80 (79)
Sequences: 760
Seq/Len: 9.62

EX7S
Paralog alert: 0.00 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
17_E 41_R 6.046 1.00
24_R 34_E 2.566 1.00
40_E 59_R 2.206 1.00
31_P 35_A 2.104 1.00
39_F 64_L 2.08 1.00
40_E 44_Q 1.971 1.00
14_A 48_Q 1.832 1.00
51_A 55_Q 1.802 1.00
37_N 40_E 1.578 1.00
14_A 49_G 1.571 1.00
36_L 56_A 1.537 1.00
21_I 38_E 1.516 1.00
34_E 37_N 1.444 1.00
11_F 15_L 1.372 0.99
22_V 26_E 1.297 0.99
36_L 58_Q 1.261 0.99
33_E 52_K 1.222 0.98
62_I 75_F 1.196 0.98
11_F 56_A 1.19 0.98
30_L 38_E 1.188 0.98
22_V 46_A 1.159 0.97
10_S 13_K 1.153 0.97
13_K 16_S 1.124 0.96
57_E 63_L 1.112 0.96
47_R 51_A 1.107 0.96
2_P 5_N 1.098 0.96
24_R 38_E 1.096 0.96
22_V 42_G 1.091 0.95
10_S 51_A 1.074 0.95
14_A 52_K 1.052 0.94
50_Q 54_Q 1.041 0.94
15_L 56_A 1.035 0.93
41_R 60_V 1.028 0.93
61_Q 65_S 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1vp7A60.9599.70.15Contact Map0.536
2psqA20.362510.20.879Contact Map0.72
2w1iA20.33758.10.885Contact Map0.5
3ugcA10.33757.20.888Contact Map0.503
3lxpA10.387570.888Contact Map0.696
3mxzA10.66256.80.889Contact Map0.213
2f9yA10.9256.30.89Contact Map0.11
2ozoA10.4756.20.891Contact Map0.289
3plsA10.38755.80.892Contact Map0.285
2ymbA40.96255.80.893Contact Map0.58

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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