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OPENSEQ.org
UXAC - Uronate isomerase
UniProt: P0A8G3 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12737
Length: 470 (467)
Sequences: 485
Seq/Len: 1.04
UXAC
Paralog alert: 0.04 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
260_R 271_E 3.905 1.00
90_A 121_P 3.596 1.00
158_D 182_P 2.907 1.00
8_D 17_R 2.79 1.00
82_R 125_D 2.5 0.99
86_D 125_D 2.497 0.99
39_Q 43_E 2.445 0.99
387_K 441_E 2.444 0.99
437_V 449_L 2.38 0.99
114_I 127_I 2.376 0.99
116_G 123_T 2.318 0.99
87_A 90_A 2.31 0.99
116_G 126_E 2.296 0.99
230_A 235_K 2.266 0.98
68_N 405_R 2.25 0.98
34_C 419_Y 2.243 0.98
49_N 81_D 2.217 0.98
214_R 217_D 2.174 0.98
306_L 335_S 2.171 0.98
44_D 141_S 2.162 0.98
88_W 100_L 2.159 0.98
48_K 52_D 2.158 0.98
15_F 438_E 2.15 0.98
27_Q 459_N 2.144 0.98
125_D 129_N 2.136 0.97
110_R 423_E 2.135 0.97
253_E 274_Q 2.112 0.97
152_K 462_R 2.082 0.97
205_G 211_D 2.065 0.97
82_R 86_D 2.06 0.97
391_E 431_Q 2.015 0.96
433_I 453_V 2.009 0.96
155_G 183_S 1.96 0.95
250_N 253_E 1.956 0.95
109_R 115_T 1.955 0.95
23_Y 454_K 1.947 0.95
73_R 78_D 1.92 0.94
122_S 447_N 1.881 0.94
267_L 272_V 1.859 0.93
347_I 407_V 1.851 0.93
455_N 459_N 1.847 0.93
74_L 87_A 1.833 0.92
236_V 293_V 1.825 0.92
147_Q 177_T 1.818 0.92
183_S 236_V 1.793 0.91
215_F 278_A 1.785 0.91
216_A 251_E 1.774 0.91
120_S 123_T 1.767 0.90
226_L 287_Y 1.754 0.90
26_D 454_K 1.749 0.90
88_W 91_T 1.749 0.90
362_M 365_N 1.744 0.90
89_A 118_L 1.742 0.90
320_S 365_N 1.723 0.89
44_D 143_R 1.689 0.88
331_S 362_M 1.678 0.87
184_W 222_L 1.673 0.87
433_I 449_L 1.667 0.87
67_T 400_L 1.656 0.86
30_F 467_I 1.652 0.86
227_D 290_R 1.65 0.86
86_D 121_P 1.635 0.85
114_I 130_E 1.626 0.85
454_K 459_N 1.619 0.85
360_G 400_L 1.613 0.84
215_F 254_L 1.596 0.83
285_A 340_E 1.593 0.83
170_I 180_V 1.585 0.83
80_S 83_E 1.546 0.81
357_E 392_R 1.539 0.80
155_G 236_V 1.536 0.80
12_D 431_Q 1.532 0.80
198_N 262_L 1.527 0.79
372_P 405_R 1.505 0.78
130_E 134_L 1.504 0.78
204_L 222_L 1.498 0.78
129_N 133_E 1.489 0.77
228_H 231_A 1.483 0.77
155_G 293_V 1.473 0.76
432_M 436_W 1.472 0.76
143_R 173_D 1.464 0.75
133_E 137_Q 1.453 0.75
160_P 236_V 1.451 0.74
327_A 358_V 1.44 0.74
307_R 338_N 1.435 0.73
52_D 81_D 1.432 0.73
155_G 181_L 1.431 0.73
268_S 271_E 1.427 0.73
18_R 22_D 1.421 0.72
201_M 218_L 1.416 0.72
146_M 149_M 1.414 0.72
212_I 217_D 1.411 0.71
223_T 286_E 1.402 0.71
92_V 105_H 1.393 0.70
92_V 95_T 1.388 0.70
294_Q 344_P 1.386 0.70
254_L 278_A 1.385 0.69
155_G 467_I 1.378 0.69
30_F 152_K 1.375 0.69
42_A 169_E 1.375 0.69
14_E 17_R 1.367 0.68
161_I 208_S 1.359 0.67
168_A 228_H 1.357 0.67
387_K 428_I 1.355 0.67
223_T 289_R 1.354 0.67
44_D 147_Q 1.337 0.65
116_G 127_I 1.335 0.65
270_H 274_Q 1.329 0.65
255_D 258_L 1.329 0.65
97_G 436_W 1.325 0.64
285_A 342_L 1.32 0.64
348_L 359_L 1.314 0.63
335_S 339_E 1.306 0.63
67_T 360_G 1.304 0.63
46_R 138_D 1.299 0.62
95_T 402_L 1.29 0.61
333_L 337_Q 1.289 0.61
68_N 91_T 1.285 0.61
357_E 386_Q 1.264 0.59
184_W 226_L 1.262 0.59
66_R 305_N 1.261 0.59
34_C 146_M 1.26 0.59
299_G 350_C 1.258 0.59
108_L 114_I 1.256 0.58
82_R 129_N 1.256 0.58
92_V 404_S 1.254 0.58
286_E 290_R 1.254 0.58
27_Q 152_K 1.252 0.58
44_D 138_D 1.252 0.58
39_Q 166_H 1.235 0.56
111_P 149_M 1.231 0.56
458_F 462_R 1.229 0.56
116_G 130_E 1.228 0.56
106_L 110_R 1.227 0.56
168_A 232_H 1.224 0.55
308_Q 318_F 1.215 0.55
214_R 255_D 1.213 0.54
356_N 377_F 1.203 0.53
123_T 126_E 1.198 0.53
331_S 365_N 1.198 0.53
70_V 348_L 1.198 0.53
286_E 289_R 1.195 0.53
153_M 181_L 1.193 0.52
257_I 274_Q 1.19 0.52
228_H 232_H 1.189 0.52
44_D 177_T 1.189 0.52
390_M 394_M 1.18 0.51
199_D 202_A 1.18 0.51
450_G 455_N 1.175 0.51
88_W 95_T 1.172 0.51
298_I 326_M 1.171 0.50
212_I 258_L 1.169 0.50
216_A 255_D 1.162 0.50
140_F 176_F 1.159 0.49
34_C 154_V 1.157 0.49
279_V 283_L 1.155 0.49
312_L 316_V 1.148 0.48
36_L 154_V 1.144 0.48
166_H 169_E 1.141 0.48
285_A 337_Q 1.14 0.48
184_W 204_L 1.139 0.47
217_D 220_T 1.136 0.47
332_K 335_S 1.129 0.46
70_V 91_T 1.121 0.46
152_K 458_F 1.119 0.46
205_G 208_S 1.116 0.45
66_R 318_F 1.115 0.45
193_E 276_K 1.114 0.45
104_T 140_F 1.109 0.45
303_N 309_F 1.107 0.44
318_F 400_L 1.106 0.44
283_L 287_Y 1.106 0.44
40_Q 45_Y 1.104 0.44
210_T 224_K 1.102 0.44
89_A 123_T 1.095 0.43
219_Q 282_F 1.094 0.43
50_L 131_C 1.093 0.43
219_Q 286_E 1.091 0.43
95_T 386_Q 1.089 0.43
169_E 260_R 1.086 0.43
183_S 293_V 1.085 0.42
55_L 84_K 1.085 0.42
43_E 166_H 1.083 0.42
42_A 170_I 1.083 0.42
12_D 435_R 1.078 0.42
108_L 127_I 1.074 0.41
25_K 463_D 1.071 0.41
146_M 419_Y 1.071 0.41
403_L 429_L 1.07 0.41
296_Y 346_T 1.066 0.41
406_F 425_F 1.065 0.41
305_N 339_E 1.062 0.40
94_H 455_N 1.061 0.40
7_E 25_K 1.059 0.40
51_Y 81_D 1.056 0.40
299_G 365_N 1.055 0.40
143_R 176_F 1.05 0.39
82_R 166_H 1.05 0.39
50_L 132_N 1.05 0.39
247_A 273_A 1.05 0.39
161_I 207_V 1.048 0.39
54_W 107_E 1.047 0.39
215_F 300_A 1.047 0.39
126_E 133_E 1.046 0.39
240_A 322_N 1.043 0.39
459_N 462_R 1.042 0.39
45_Y 56_K 1.039 0.38
51_Y 84_K 1.038 0.38
53_I 145_I 1.038 0.38
202_A 262_L 1.034 0.38
300_A 351_L 1.033 0.38
387_K 439_A 1.033 0.38
218_L 283_L 1.031 0.38
97_G 294_Q 1.028 0.37
193_E 272_V 1.026 0.37
170_I 176_F 1.025 0.37
92_V 360_G 1.024 0.37
70_V 329_E 1.024 0.37
52_D 132_N 1.023 0.37
282_F 285_A 1.023 0.37
281_V 336_K 1.017 0.36
41_I 180_V 1.016 0.36
160_P 188_K 1.014 0.36
230_A 292_W 1.01 0.36
451_E 455_N 1.01 0.36
255_D 259_A 1.007 0.35
435_R 439_A 1.003 0.35
190_F 279_V 1.001 0.35
254_L 258_L 1 0.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3iacA30.99361000.12Contact Map0.712
2q01A30.97231000.206Contact Map0.577
1j5sA30.95321000.227Contact Map0.685
4i6vA30.90211000.383Contact Map0.485
2qeeA120.85961000.404Contact Map0.364
2qpxA10.76381000.653Contact Map0.386
2dvtA40.614992.60.974Contact Map0.516
3cjpA20.559683.70.978Contact Map0.668
3irsA30.53482.50.978Contact Map0.207
1yixA20.512876.80.979Contact Map0.174
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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