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OPENSEQ.org
UVRC - UvrABC system protein C
UniProt: P0A8G0 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11063
Length: 610 (598)
Sequences: 1548
Seq/Len: 2.59
UVRC
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
14_V 43_L 4.199 1.00
111_T 185_E 4.073 1.00
16_S 38_D 3.893 1.00
602_E 606_W 3.697 1.00
222_E 225_E 3.444 1.00
605_F 609_K 3.287 1.00
30_V 88_Y 3.244 1.00
421_L 424_E 3.238 1.00
25_D 29_T 3.167 1.00
184_S 187_E 3.162 1.00
60_V 63_I 3.118 1.00
582_L 590_I 3.085 1.00
416_D 421_L 2.978 1.00
559_E 569_R 2.858 1.00
429_N 548_K 2.831 1.00
213_R 229_I 2.828 1.00
407_Q 552_V 2.735 1.00
596_I 604_I 2.71 1.00
443_N 477_N 2.633 1.00
472_L 495_G 2.52 1.00
28_G 65_Q 2.495 1.00
127_E 196_R 2.414 1.00
398_F 450_Y 2.382 1.00
429_N 544_G 2.379 1.00
598_Q 602_E 2.369 1.00
496_V 530_I 2.323 1.00
469_K 473_A 2.252 1.00
216_T 220_N 2.241 1.00
211_I 237_R 2.175 1.00
56_T 59_L 2.149 1.00
183_V 187_E 2.14 1.00
464_L 494_L 2.135 1.00
383_L 526_A 2.109 1.00
589_E 592_K 2.061 1.00
210_L 233_I 2.054 1.00
215_E 218_S 2.041 1.00
16_S 40_K 2.039 1.00
169_Y 176_G 1.942 0.99
393_K 417_A 1.941 0.99
31_I 55_K 1.928 0.99
31_I 56_T 1.918 0.99
227_A 231_D 1.905 0.99
587_V 602_E 1.876 0.99
30_V 33_V 1.869 0.99
211_I 215_E 1.868 0.99
197_L 202_K 1.855 0.99
207_L 233_I 1.843 0.99
106_F 126_G 1.828 0.99
107_L 196_R 1.823 0.99
446_L 478_V 1.813 0.99
398_F 446_L 1.803 0.99
319_L 343_V 1.77 0.98
564_V 604_I 1.757 0.98
581_G 584_N 1.743 0.98
472_L 510_F 1.735 0.98
215_E 219_Q 1.728 0.98
117_M 139_R 1.708 0.98
591_A 598_Q 1.707 0.98
217_A 229_I 1.684 0.98
476_K 493_L 1.681 0.98
408_T 441_A 1.678 0.97
586_S 589_E 1.675 0.97
398_F 412_C 1.663 0.97
10_F 65_Q 1.66 0.97
439_Y 470_G 1.654 0.97
183_V 191_Q 1.64 0.97
26_A 64_Q 1.636 0.97
395_M 533_I 1.622 0.97
544_G 548_K 1.62 0.97
439_Y 474_Q 1.619 0.97
23_M 63_I 1.614 0.97
256_G 320_D 1.596 0.96
402_H 430_I 1.589 0.96
402_H 433_I 1.58 0.96
536_E 539_D 1.572 0.96
397_C 533_I 1.563 0.96
59_L 63_I 1.563 0.96
427_R 544_G 1.555 0.96
402_H 436_G 1.554 0.96
473_A 476_K 1.554 0.96
396_E 449_R 1.545 0.95
402_H 408_T 1.545 0.95
112_H 159_Y 1.545 0.95
213_R 225_E 1.542 0.95
397_C 413_V 1.537 0.95
597_S 600_L 1.536 0.95
443_N 478_V 1.536 0.95
484_V 491_P 1.536 0.95
270_F 303_F 1.534 0.95
403_T 545_H 1.53 0.95
212_S 216_T 1.521 0.95
72_H 244_F 1.518 0.95
207_L 237_R 1.512 0.95
587_V 591_A 1.503 0.94
394_R 416_D 1.503 0.94
450_Y 463_I 1.498 0.94
555_T 560_T 1.489 0.94
411_S 540_H 1.485 0.94
107_L 115_L 1.472 0.94
304_Y 314_P 1.472 0.94
410_A 441_A 1.47 0.93
55_K 59_L 1.455 0.93
410_A 430_I 1.454 0.93
527_L 534_R 1.446 0.93
38_D 41_K 1.442 0.93
414_V 424_E 1.439 0.93
150_P 195_V 1.438 0.92
402_H 437_D 1.433 0.92
542_I 546_R 1.429 0.92
527_L 531_Q 1.426 0.92
564_V 600_L 1.423 0.92
319_L 345_T 1.423 0.92
431_T 444_Q 1.419 0.92
25_D 62_Q 1.418 0.92
225_E 228_R 1.416 0.92
31_I 91_R 1.415 0.92
447_R 478_V 1.412 0.92
507_E 534_R 1.404 0.91
329_L 343_V 1.403 0.91
580_Q 584_N 1.4 0.91
185_E 189_A 1.399 0.91
478_V 482_L 1.399 0.91
506_L 534_R 1.398 0.91
562_E 603_K 1.396 0.91
112_H 181_G 1.394 0.91
499_G 534_R 1.38 0.90
463_I 479_F 1.38 0.90
176_G 182_L 1.378 0.90
331_D 335_E 1.377 0.90
45_S 48_R 1.375 0.90
600_L 603_K 1.371 0.90
255_I 299_F 1.37 0.90
225_E 229_I 1.369 0.90
16_S 41_K 1.369 0.90
382_A 526_A 1.365 0.90
187_E 190_Q 1.363 0.90
600_L 604_I 1.358 0.89
411_S 537_S 1.356 0.89
415_F 420_P 1.352 0.89
476_K 480_A 1.348 0.89
409_V 548_K 1.348 0.89
496_V 509_L 1.348 0.89
474_Q 478_V 1.342 0.89
443_N 447_R 1.34 0.88
234_Q 237_R 1.34 0.88
587_V 598_Q 1.338 0.88
179_V 182_L 1.337 0.88
397_C 537_S 1.334 0.88
428_Y 452_K 1.327 0.88
74_E 78_L 1.326 0.88
24_Y 65_Q 1.315 0.87
259_F 292_L 1.315 0.87
24_Y 67_D 1.313 0.87
258_A 363_A 1.312 0.87
497_A 508_T 1.311 0.87
25_D 31_I 1.31 0.87
447_R 481_E 1.309 0.87
352_A 356_K 1.306 0.87
464_L 496_V 1.305 0.87
412_C 428_Y 1.301 0.86
14_V 66_I 1.301 0.86
400_I 411_S 1.299 0.86
497_A 527_L 1.281 0.85
579_L 582_L 1.28 0.85
397_C 464_L 1.274 0.85
545_H 549_R 1.273 0.85
300_V 317_I 1.27 0.85
55_K 94_V 1.266 0.84
394_R 414_V 1.266 0.84
217_A 222_E 1.261 0.84
11_L 14_V 1.259 0.84
359_R 363_A 1.257 0.84
379_R 529_V 1.255 0.84
596_I 600_L 1.252 0.83
150_P 175_L 1.25 0.83
499_G 502_R 1.248 0.83
389_L 492_L 1.246 0.83
151_I 195_V 1.243 0.83
575_Y 593_V 1.242 0.83
400_I 410_A 1.24 0.83
227_A 230_R 1.238 0.83
430_I 441_A 1.235 0.82
48_R 51_L 1.234 0.82
209_Q 213_R 1.234 0.82
420_P 532_H 1.231 0.82
356_K 359_R 1.225 0.82
433_I 440_A 1.224 0.82
477_N 481_E 1.223 0.81
443_N 481_E 1.223 0.81
8_K 12_K 1.221 0.81
476_K 512_E 1.22 0.81
575_Y 592_K 1.216 0.81
267_H 279_S 1.213 0.81
410_A 445_V 1.212 0.81
153_Q 168_Q 1.208 0.80
576_M 593_V 1.204 0.80
190_Q 193_E 1.202 0.80
320_D 359_R 1.2 0.80
110_D 156_N 1.198 0.80
556_S 559_E 1.196 0.79
547_K 551_K 1.189 0.79
509_L 530_I 1.189 0.79
499_G 503_K 1.186 0.79
561_I 604_I 1.183 0.78
566_P 570_Q 1.176 0.78
381_T 384_A 1.172 0.77
268_V 303_F 1.171 0.77
394_R 424_E 1.169 0.77
497_A 534_R 1.168 0.77
117_M 138_V 1.168 0.77
400_I 408_T 1.164 0.77
398_F 410_A 1.161 0.77
317_I 343_V 1.16 0.76
534_R 537_S 1.16 0.76
363_A 367_T 1.159 0.76
299_F 303_F 1.157 0.76
255_I 268_V 1.156 0.76
168_Q 173_R 1.155 0.76
254_V 271_I 1.148 0.75
406_E 553_K 1.147 0.75
165_P 179_V 1.145 0.75
22_R 67_D 1.142 0.75
411_S 541_A 1.14 0.75
544_G 547_K 1.138 0.74
316_E 351_R 1.138 0.74
506_L 527_L 1.132 0.74
404_M 545_H 1.131 0.74
17_Q 360_T 1.124 0.73
256_G 362_A 1.124 0.73
115_L 145_L 1.121 0.73
397_C 542_I 1.115 0.72
446_L 474_Q 1.115 0.72
258_A 366_L 1.113 0.72
379_R 526_A 1.111 0.72
437_D 443_N 1.109 0.72
175_L 183_V 1.104 0.71
318_L 344_Q 1.102 0.71
109_G 126_G 1.097 0.71
398_F 442_M 1.091 0.70
55_K 58_A 1.091 0.70
269_L 279_S 1.09 0.70
601_A 604_I 1.089 0.70
18_P 21_Y 1.089 0.70
213_R 216_T 1.088 0.70
108_S 116_A 1.088 0.70
398_F 463_I 1.086 0.69
502_R 534_R 1.084 0.69
150_P 191_Q 1.083 0.69
432_G 444_Q 1.083 0.69
301_G 329_L 1.081 0.69
122_K 126_G 1.079 0.69
7_A 11_L 1.077 0.69
442_M 475_A 1.072 0.68
22_R 69_T 1.066 0.67
391_E 461_D 1.062 0.67
297_E 325_D 1.057 0.66
510_F 517_G 1.056 0.66
453_A 456_D 1.056 0.66
269_L 358_A 1.054 0.66
433_I 441_A 1.052 0.66
556_S 569_R 1.051 0.66
402_H 441_A 1.051 0.66
465_I 475_A 1.051 0.66
256_G 355_L 1.05 0.66
348_R 351_R 1.049 0.66
437_D 470_G 1.048 0.66
315_G 339_R 1.046 0.65
47_F 60_V 1.046 0.65
229_I 233_I 1.042 0.65
531_Q 534_R 1.04 0.65
207_L 211_I 1.04 0.65
590_I 608_L 1.039 0.65
587_V 601_A 1.038 0.64
82_H 101_S 1.037 0.64
603_K 606_W 1.037 0.64
327_T 331_D 1.037 0.64
210_L 229_I 1.035 0.64
464_L 533_I 1.034 0.64
166_C 178_C 1.032 0.64
256_G 359_R 1.031 0.64
479_F 493_L 1.029 0.63
151_I 192_V 1.028 0.63
401_S 542_I 1.028 0.63
497_A 507_E 1.027 0.63
67_D 279_S 1.025 0.63
461_D 492_L 1.025 0.63
471_Q 475_A 1.025 0.63
531_Q 535_D 1.024 0.63
23_M 66_I 1.024 0.63
472_L 475_A 1.023 0.63
599_G 603_K 1.022 0.63
189_A 193_E 1.02 0.62
97_R 101_S 1.016 0.62
446_L 475_A 1.012 0.62
166_C 174_C 1.011 0.61
497_A 510_F 1.01 0.61
337_A 341_I 1.01 0.61
326_K 330_A 1.007 0.61
10_F 13_T 1.004 0.61
402_H 435_P 1.004 0.61
537_S 540_H 1.003 0.60
571_M 593_V 1.001 0.60
439_Y 473_A 1 0.60
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3c65A10.36721000.629Contact Map0.676
2nrtA10.3591000.639Contact Map0.682
2nrrA10.2591000.709Contact Map0.735
2bgwA20.34751000.829Contact Map0.279
1yd6A40.16231000.838Contact Map0.822
1yd0A10.15741000.846Contact Map0.66
2wshA40.1591000.85Contact Map0.418
3gocA20.35741000.854Contact Map0.292
4gfjA10.66391000.871Contact Map0.313
2w36A20.29341000.872Contact Map0.309
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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