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OPENSEQ.org
UVRB - UvrABC system protein B
UniProt: P0A8F8 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11062
Length: 673 (669)
Sequences: 1359
Seq/Len: 2.03
UVRB
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
6_K 83_E 6.206 1.00
49_I 336_V 5.504 1.00
40_V 43_S 4.835 1.00
271_R 286_L 4.599 1.00
562_A 566_G 4.58 1.00
202_I 214_V 4.051 1.00
270_R 273_V 3.91 1.00
436_L 471_E 3.528 1.00
359_E 363_E 3.501 1.00
8_N 83_E 3.493 1.00
25_E 55_D 3.456 1.00
200_I 216_L 3.41 1.00
447_E 547_N 3.403 1.00
435_L 451_V 3.369 1.00
264_K 298_N 3.355 1.00
54_A 57_Q 3.318 1.00
645_Q 649_N 3.196 1.00
34_H 391_Y 3.164 1.00
489_I 512_M 3.128 1.00
577_K 581_E 3.079 1.00
274_L 286_L 3.019 1.00
317_G 320_E 2.968 1.00
134_R 332_D 2.946 1.00
63_L 347_I 2.923 1.00
22_R 55_D 2.922 1.00
267_L 271_R 2.864 1.00
532_E 563_K 2.864 1.00
355_R 359_E 2.843 1.00
7_L 51_N 2.827 1.00
539_I 564_A 2.776 1.00
53_I 137_V 2.769 1.00
7_L 54_A 2.745 1.00
262_E 312_F 2.734 1.00
51_N 54_A 2.732 1.00
266_E 312_F 2.71 1.00
546_V 588_G 2.6 1.00
419_L 576_Q 2.593 1.00
275_L 287_T 2.582 1.00
19_E 22_R 2.582 1.00
559_P 563_K 2.565 1.00
442_R 549_K 2.525 1.00
90_V 482_T 2.505 1.00
422_I 549_K 2.473 1.00
447_E 516_S 2.461 1.00
60_T 334_L 2.46 1.00
287_T 291_Q 2.455 1.00
272_K 276_E 2.451 1.00
576_Q 580_E 2.432 1.00
474_R 497_F 2.431 1.00
62_V 77_M 2.408 1.00
214_V 221_V 2.397 1.00
28_L 56_L 2.351 1.00
639_L 662_L 2.348 1.00
173_L 200_I 2.345 1.00
103_P 360_T 2.344 1.00
28_L 390_I 2.295 1.00
383_E 399_Y 2.275 1.00
640_E 666_R 2.258 1.00
654_E 657_Q 2.237 1.00
273_V 277_N 2.235 1.00
271_R 287_T 2.224 1.00
60_T 336_V 2.214 1.00
36_T 404_S 2.198 1.00
260_M 294_L 2.197 1.00
26_E 30_D 2.193 1.00
491_D 496_E 2.167 1.00
172_I 200_I 2.156 1.00
442_R 447_E 2.139 0.99
14_S 578_Y 2.123 0.99
490_R 494_L 2.116 0.99
573_E 577_K 2.11 0.99
559_P 562_A 2.095 0.99
436_L 469_H 2.092 0.99
19_E 23_R 2.064 0.99
442_R 516_S 2.049 0.99
424_E 549_K 2.047 0.99
270_R 274_L 2.034 0.99
49_I 390_I 2.001 0.99
280_L 284_Q 1.962 0.99
22_R 26_E 1.959 0.99
526_E 560_S 1.956 0.99
587_Q 590_N 1.955 0.99
443_A 472_R 1.948 0.99
187_A 457_R 1.945 0.99
27_G 32_L 1.921 0.99
337_V 344_I 1.92 0.99
642_L 654_E 1.916 0.99
557_I 565_I 1.897 0.98
618_V 623_V 1.892 0.98
426_R 438_E 1.883 0.98
423_I 565_I 1.873 0.98
561_M 565_I 1.864 0.98
352_R 356_A 1.86 0.98
398_N 533_R 1.849 0.98
567_E 570_R 1.846 0.98
335_L 389_T 1.837 0.98
47_F 51_N 1.832 0.98
223_R 237_T 1.83 0.98
321_P 385_L 1.824 0.98
355_R 372_L 1.784 0.97
441_Q 444_A 1.777 0.97
29_E 55_D 1.755 0.97
438_E 441_Q 1.743 0.97
62_V 139_V 1.719 0.97
646_H 658_I 1.718 0.97
497_F 500_L 1.713 0.96
36_T 391_Y 1.706 0.96
266_E 370_S 1.706 0.96
260_M 298_N 1.662 0.96
636_I 665_L 1.656 0.95
188_F 211_A 1.65 0.95
34_H 403_K 1.647 0.95
175_R 178_E 1.638 0.95
211_A 227_F 1.619 0.95
162_T 165_M 1.617 0.95
105_S 304_S 1.611 0.95
264_K 291_Q 1.609 0.94
87_E 125_S 1.606 0.94
23_R 407_D 1.598 0.94
256_I 297_M 1.597 0.94
445_I 547_N 1.588 0.94
632_L 662_L 1.578 0.94
426_R 434_D 1.572 0.94
161_L 221_V 1.563 0.93
172_I 216_L 1.552 0.93
349_G 378_K 1.535 0.92
13_P 21_I 1.533 0.92
635_K 638_E 1.531 0.92
434_D 553_Y 1.522 0.92
268_A 272_K 1.52 0.92
443_A 471_E 1.519 0.92
344_I 348_G 1.511 0.92
412_V 574_K 1.505 0.91
212_L 241_F 1.499 0.91
271_R 274_L 1.488 0.91
127_T 248_H 1.474 0.90
49_I 392_V 1.461 0.90
262_E 266_E 1.459 0.90
329_L 333_G 1.454 0.90
121_Q 208_D 1.446 0.89
58_R 134_R 1.444 0.89
257_V 298_N 1.44 0.89
271_R 275_L 1.436 0.89
311_R 373_D 1.435 0.89
25_E 29_E 1.434 0.89
539_I 552_L 1.408 0.87
25_E 56_L 1.402 0.87
398_N 402_E 1.4 0.87
173_L 177_A 1.4 0.87
441_Q 445_I 1.393 0.87
27_G 35_Q 1.39 0.87
253_R 257_V 1.388 0.86
56_L 60_T 1.384 0.86
442_R 446_N 1.36 0.85
516_S 547_N 1.357 0.85
577_K 580_E 1.35 0.84
130_M 136_V 1.343 0.84
569_E 573_E 1.342 0.84
422_I 576_Q 1.34 0.84
64_A 73_L 1.338 0.84
58_R 336_V 1.331 0.83
281_L 286_L 1.329 0.83
311_R 318_P 1.327 0.83
125_S 129_A 1.326 0.83
58_R 388_Q 1.319 0.82
557_I 562_A 1.319 0.82
81_F 137_V 1.316 0.82
573_E 581_E 1.315 0.82
157_M 252_P 1.296 0.81
24_L 27_G 1.295 0.81
65_P 343_T 1.293 0.81
266_E 269_A 1.292 0.81
435_L 519_A 1.291 0.80
53_I 62_V 1.29 0.80
661_Q 664_Q 1.288 0.80
422_I 569_E 1.28 0.80
642_L 658_I 1.279 0.80
5_F 60_T 1.273 0.79
651_E 654_E 1.273 0.79
120_E 190_R 1.269 0.79
7_L 57_Q 1.268 0.79
124_L 154_Y 1.268 0.79
272_K 275_L 1.267 0.79
383_E 403_K 1.266 0.79
159_L 179_L 1.259 0.78
386_A 389_T 1.253 0.78
62_V 137_V 1.252 0.78
261_E 265_E 1.252 0.78
617_I 623_V 1.247 0.77
450_L 512_M 1.243 0.77
264_K 268_A 1.243 0.77
265_E 268_A 1.239 0.77
153_L 252_P 1.238 0.76
24_L 390_I 1.235 0.76
52_V 336_V 1.234 0.76
337_V 389_T 1.234 0.76
663_H 667_E 1.224 0.75
256_I 313_L 1.216 0.75
19_E 409_V 1.214 0.74
335_L 386_A 1.211 0.74
425_V 554_G 1.21 0.74
260_M 297_M 1.208 0.74
472_R 496_E 1.206 0.74
51_N 55_D 1.205 0.74
312_F 370_S 1.205 0.74
362_V 372_L 1.203 0.74
425_V 565_I 1.198 0.73
616_P 623_V 1.196 0.73
566_G 569_E 1.195 0.73
32_L 407_D 1.195 0.73
279_K 282_E 1.193 0.73
628_S 631_A 1.19 0.72
58_R 332_D 1.19 0.72
359_E 372_L 1.189 0.72
452_T 538_T 1.188 0.72
168_D 174_R 1.187 0.72
36_T 403_K 1.183 0.72
326_F 382_F 1.182 0.72
128_K 132_E 1.18 0.71
113_A 302_Y 1.172 0.71
471_E 499_V 1.172 0.71
6_K 54_A 1.169 0.70
580_E 583_G 1.161 0.70
162_T 240_R 1.161 0.70
657_Q 661_Q 1.161 0.70
633_Q 637_H 1.16 0.70
466_L 501_V 1.159 0.69
565_I 569_E 1.157 0.69
29_E 56_L 1.152 0.69
326_F 335_L 1.152 0.69
640_E 644_M 1.149 0.69
161_L 167_I 1.146 0.68
211_A 229_P 1.146 0.68
159_L 172_I 1.145 0.68
153_L 255_R 1.145 0.68
638_E 642_L 1.14 0.68
161_L 243_I 1.129 0.67
118_H 122_M 1.126 0.66
216_L 224_L 1.126 0.66
294_L 298_N 1.118 0.65
63_L 335_L 1.117 0.65
451_V 521_L 1.116 0.65
273_V 286_L 1.114 0.65
203_F 211_A 1.112 0.65
215_E 223_R 1.112 0.65
429_A 555_D 1.111 0.65
77_M 336_V 1.11 0.65
337_V 347_I 1.109 0.65
348_G 352_R 1.104 0.64
569_E 576_Q 1.104 0.64
167_I 172_I 1.099 0.64
264_K 294_L 1.088 0.62
473_V 501_V 1.087 0.62
172_I 214_V 1.083 0.62
520_I 552_L 1.074 0.61
19_E 574_K 1.072 0.61
12_K 51_N 1.069 0.60
255_R 258_Q 1.069 0.60
448_R 495_G 1.068 0.60
161_L 172_I 1.068 0.60
321_P 324_T 1.065 0.60
336_V 390_I 1.064 0.60
251_T 433_D 1.062 0.60
348_G 398_N 1.062 0.60
347_I 386_A 1.055 0.59
636_I 662_L 1.052 0.58
487_E 490_R 1.049 0.58
58_R 334_L 1.046 0.58
269_A 273_V 1.039 0.57
173_L 195_V 1.036 0.57
258_Q 312_F 1.035 0.57
265_E 269_A 1.035 0.57
189_Q 192_T 1.029 0.56
153_L 156_K 1.028 0.56
404_S 408_V 1.028 0.56
258_Q 262_E 1.026 0.56
401_L 404_S 1.024 0.55
438_E 551_I 1.024 0.55
65_P 131_L 1.019 0.55
226_L 238_I 1.015 0.54
463_T 473_V 1.008 0.54
79_E 594_V 1.008 0.54
419_L 546_V 1.006 0.53
150_D 314_S 1.004 0.53
486_M 596_I 1.004 0.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2d7dA10.98071000.485Contact Map0.702
1c4oA10.96581000.495Contact Map0.744
2eyqA20.83661000.726Contact Map0.489
3hjhA10.69241000.738Contact Map0.533
2ocaA10.53941000.903Contact Map0.443
1wp9A60.49781000.906Contact Map0.513
1gm5A10.58991000.906Contact Map0.57
2fwrA40.46661000.906Contact Map0.586
3tbkA10.54831000.907Contact Map0.543
4a4zA10.61661000.908Contact Map0.431
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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