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OPENSEQ.org

UPP - Uracil phosphoribosyltransferase
UniProt: P0A8F0 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11332
Length: 208 (208)
Sequences: 1599
Seq/Len: 7.69

UPP
Paralog alert: 0.07 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
167_A 171_K 4.376 1.00
21_Q 55_E 4.341 1.00
53_T 60_P 3.968 1.00
108_L 191_G 3.928 1.00
51_K 62_E 3.216 1.00
161_A 180_T 2.907 1.00
166_I 183_I 2.775 1.00
16_G 63_I 2.719 1.00
26_K 30_E 2.646 1.00
139_V 156_V 2.565 1.00
140_I 168_A 2.563 1.00
33_S 89_E 2.517 1.00
59_G 185_Q 2.504 1.00
3_I 183_I 2.38 1.00
53_T 62_E 2.282 1.00
55_E 60_P 2.22 1.00
140_I 172_A 2.15 1.00
156_V 169_L 2.134 1.00
143_I 169_L 2.076 1.00
40_T 87_V 2.064 1.00
50_E 65_Q 1.951 1.00
51_K 64_D 1.929 1.00
144_D 148_K 1.891 1.00
73_V 129_V 1.886 1.00
102_Y 111_V 1.824 1.00
52_V 65_Q 1.82 1.00
58_N 194_I 1.798 1.00
168_A 172_A 1.797 1.00
147_K 173_H 1.775 1.00
144_D 172_A 1.771 1.00
47_L 71_I 1.762 1.00
167_A 170_E 1.711 1.00
188_N 194_I 1.686 1.00
166_I 178_L 1.609 1.00
18_M 32_A 1.572 1.00
109_E 168_A 1.568 1.00
163_P 167_A 1.557 1.00
42_E 45_A 1.552 1.00
146_L 151_C 1.534 1.00
12_K 64_D 1.534 1.00
74_V 97_S 1.531 1.00
54_I 61_V 1.519 1.00
5_E 183_I 1.513 1.00
37_S 89_E 1.496 0.99
125_M 153_S 1.492 0.99
24_S 27_R 1.484 0.99
75_P 81_L 1.474 0.99
11_V 35_V 1.461 0.99
74_V 117_L 1.44 0.99
141_A 144_D 1.422 0.99
185_Q 194_I 1.421 0.99
186_G 194_I 1.41 0.99
110_P 137_G 1.405 0.99
59_G 194_I 1.396 0.99
72_T 121_I 1.375 0.99
36_G 83_M 1.357 0.99
50_E 67_K 1.355 0.99
105_E 190_H 1.353 0.99
46_D 155_K 1.341 0.99
143_I 154_I 1.34 0.99
2_K 177_E 1.299 0.98
48_E 67_K 1.294 0.98
33_S 85_D 1.284 0.98
14_K 34_E 1.279 0.98
6_V 180_T 1.277 0.98
140_I 144_D 1.277 0.98
147_K 175_D 1.27 0.98
104_N 111_V 1.254 0.97
39_L 43_A 1.249 0.97
23_I 203_K 1.245 0.97
87_V 157_L 1.243 0.97
15_L 181_A 1.225 0.97
158_V 180_T 1.197 0.96
169_L 178_L 1.176 0.96
145_L 148_K 1.161 0.96
43_A 157_L 1.129 0.95
97_S 117_L 1.106 0.94
126_A 151_C 1.087 0.93
99_V 142_T 1.08 0.93
99_V 128_I 1.079 0.93
195_P 198_G 1.06 0.92
44_T 91_V 1.057 0.92
32_A 159_L 1.04 0.91
88_L 96_I 1.027 0.90
144_D 173_H 1.025 0.90
163_P 185_Q 1.018 0.89
164_E 186_G 1.015 0.89
81_L 98_V 1.013 0.89
11_V 38_L 1.011 0.89
128_I 169_L 1.007 0.89
121_I 151_C 1.005 0.89
6_V 11_V 1.002 0.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1xttA40.99041000.215Contact Map0.77
3dmpA40.99041000.257Contact Map0.764
2ehjA411000.259Contact Map0.826
1o5oA411000.26Contact Map0.851
1bd3D40.99521000.263Contact Map0.727
1v9sA411000.268Contact Map0.846
2e55A40.99041000.284Contact Map0.826
1i5eA211000.343Contact Map0.788
3s5jB20.947199.80.733Contact Map0.45
1qb7A10.908799.70.757Contact Map0.417

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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