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OPENSEQ.org

NRDR - Transcriptional repressor NrdR
UniProt: P0A8D0 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11320
Length: 149 (148)
Sequences: 1009
Seq/Len: 6.82

NRDR
Paralog alert: 0.00 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
90_H 115_Q 3.984 1.00
5_F 36_E 2.935 1.00
72_R 75_E 2.639 1.00
70_M 87_A 2.57 1.00
80_S 83_D 2.551 1.00
70_M 84_V 2.378 1.00
77_R 120_D 2.36 1.00
143_E 146_R 2.225 1.00
51_V 108_I 2.097 1.00
64_E 68_S 2.041 1.00
58_R 102_E 1.971 1.00
54_S 106_K 1.911 1.00
94_Q 115_Q 1.833 1.00
141_G 145_A 1.75 1.00
67_R 88_I 1.673 1.00
66_L 112_V 1.625 1.00
12_K 32_L 1.578 1.00
98_T 107_M 1.571 1.00
87_A 119_L 1.571 1.00
110_N 132_R 1.547 0.99
67_R 84_V 1.536 0.99
83_D 86_M 1.529 0.99
69_G 75_E 1.473 0.99
91_I 111_L 1.449 0.99
95_L 103_V 1.437 0.99
138_K 142_E 1.429 0.99
138_K 148_E 1.398 0.99
102_E 132_R 1.358 0.98
30_Q 35_N 1.353 0.98
12_K 69_G 1.345 0.98
8_A 33_V 1.328 0.98
87_A 115_Q 1.301 0.98
132_R 143_E 1.292 0.97
94_Q 114_E 1.278 0.97
18_L 25_V 1.264 0.97
10_D 33_V 1.236 0.96
121_K 133_S 1.225 0.96
82_D 86_M 1.224 0.96
83_D 119_L 1.218 0.96
6_C 13_V 1.217 0.96
41_F 45_E 1.21 0.96
63_E 92_K 1.203 0.96
69_G 72_R 1.201 0.96
125_I 135_E 1.189 0.95
58_R 113_M 1.184 0.95
52_V 102_E 1.182 0.95
104_P 107_M 1.178 0.95
12_K 143_E 1.17 0.95
30_Q 105_S 1.157 0.94
63_E 67_R 1.15 0.94
113_M 136_D 1.138 0.94
3_C 13_V 1.117 0.93
15_D 77_R 1.114 0.93
70_M 112_V 1.097 0.92
66_L 108_I 1.077 0.91
52_V 58_R 1.076 0.91
100_E 107_M 1.072 0.91
87_A 91_I 1.071 0.91
141_G 148_E 1.071 0.91
3_C 6_C 1.066 0.90
11_T 20_G 1.061 0.90
66_L 95_L 1.051 0.89
142_E 145_A 1.045 0.89
32_L 144_I 1.041 0.89
61_F 92_K 1.022 0.88
50_R 105_S 1.019 0.87
10_D 32_L 1.019 0.87
60_P 71_L 1.016 0.87
58_R 76_K 1.009 0.87
95_L 111_L 1.005 0.86
77_R 129_S 1.001 0.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3ga8A10.469898.10.861Contact Map0.533
1tfiA10.261797.80.87Contact Map0.639
3k8tA10.65197.50.879Contact Map0.22
3hncA20.65197.40.88Contact Map0.517
2xapA30.65197.40.881Contact Map0.584
3o9xA20.791994.70.908Contact Map0.467
1qypA10.268591.90.917Contact Map0.755
4c2mI20.2819900.921Contact Map0.754
1twfI10.322189.50.921Contact Map0.843
3h0gI20.261789.20.922Contact Map0.617

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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