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OPENSEQ.org
PSRP - Phosphoenolpyruvate synthase regulatory protein
UniProt: P0A8A4 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11132
Length: 277 (269)
Sequences: 720
Seq/Len: 2.68
PSRP
Paralog alert: 0.08 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
167_S 178_A 3.397 1.00
153_V 176_I 3.295 1.00
101_Q 108_P 2.936 1.00
46_E 77_E 2.715 1.00
50_R 81_I 2.54 1.00
151_A 179_A 2.46 1.00
215_A 233_C 2.39 1.00
156_L 181_Y 2.17 1.00
209_I 214_L 2.151 1.00
148_L 181_Y 2.002 1.00
240_V 244_Y 1.967 0.99
190_N 232_Q 1.913 0.99
209_I 255_T 1.885 0.99
12_I 82_I 1.821 0.99
73_I 78_I 1.805 0.99
71_Y 89_C 1.73 0.98
241_E 245_R 1.652 0.97
44_E 48_R 1.599 0.97
12_I 52_V 1.557 0.96
14_D 19_T 1.537 0.95
56_I 67_P 1.52 0.95
154_I 200_L 1.503 0.95
11_Y 24_G 1.501 0.95
100_L 104_M 1.493 0.94
135_Y 145_L 1.484 0.94
52_V 67_P 1.476 0.94
176_I 267_L 1.445 0.93
144_S 147_N 1.429 0.93
136_T 139_H 1.415 0.92
250_P 269_I 1.412 0.92
135_Y 253_N 1.411 0.92
40_L 52_V 1.41 0.92
195_A 199_P 1.406 0.92
178_A 255_T 1.382 0.91
133_I 172_M 1.372 0.90
27_V 100_L 1.365 0.90
153_V 270_M 1.364 0.90
66_R 103_E 1.353 0.90
211_P 237_V 1.346 0.89
244_Y 251_W 1.34 0.89
185_A 232_Q 1.339 0.89
156_L 197_L 1.337 0.89
136_T 238_A 1.325 0.88
139_H 147_N 1.318 0.88
149_D 199_P 1.317 0.88
79_R 94_Q 1.309 0.88
254_S 262_I 1.287 0.86
265_K 268_D 1.287 0.86
134_D 237_V 1.274 0.86
167_S 176_I 1.273 0.85
130_I 259_V 1.268 0.85
139_H 143_I 1.266 0.85
10_F 40_L 1.263 0.85
101_Q 107_D 1.255 0.84
153_V 178_A 1.239 0.83
202_H 266_I 1.238 0.83
46_E 81_I 1.231 0.83
158_V 214_L 1.23 0.83
125_K 273_S 1.23 0.83
158_V 211_P 1.227 0.83
91_D 94_Q 1.226 0.82
183_F 219_E 1.213 0.82
8_H 38_I 1.213 0.82
97_V 101_Q 1.211 0.81
29_S 114_R 1.202 0.81
258_S 261_E 1.194 0.80
24_G 70_F 1.192 0.80
183_F 240_V 1.189 0.80
71_Y 136_T 1.167 0.78
209_I 217_I 1.166 0.78
15_G 19_T 1.163 0.78
99_P 103_E 1.156 0.77
43_V 253_N 1.156 0.77
24_G 99_P 1.147 0.76
155_L 168_L 1.145 0.76
32_P 106_L 1.144 0.76
11_Y 20_A 1.142 0.76
193_L 228_A 1.142 0.76
59_I 63_T 1.141 0.76
130_I 201_Q 1.138 0.75
68_L 155_L 1.133 0.75
19_T 126_Y 1.132 0.75
133_I 259_V 1.129 0.75
156_L 243_L 1.123 0.74
183_F 211_P 1.122 0.74
193_L 197_L 1.12 0.74
43_V 120_P 1.115 0.73
133_I 243_L 1.115 0.73
53_K 69_V 1.115 0.73
98_A 102_Q 1.112 0.73
30_Q 113_H 1.111 0.73
206_G 244_Y 1.102 0.72
109_T 267_L 1.1 0.72
131_A 134_D 1.09 0.71
46_E 80_A 1.084 0.70
49_A 78_I 1.084 0.70
12_I 40_L 1.082 0.70
257_Y 265_K 1.077 0.70
9_V 12_I 1.075 0.69
77_E 80_A 1.07 0.69
131_A 177_R 1.068 0.69
19_T 74_V 1.065 0.68
213_R 217_I 1.064 0.68
135_Y 147_N 1.062 0.68
53_K 87_G 1.059 0.68
15_G 18_I 1.056 0.67
56_I 87_G 1.047 0.66
17_A 113_H 1.047 0.66
28_M 100_L 1.045 0.66
116_H 223_E 1.044 0.66
98_A 192_V 1.043 0.66
31_F 101_Q 1.043 0.66
168_L 232_Q 1.038 0.65
129_R 250_P 1.035 0.65
208_T 241_E 1.034 0.65
186_D 275_R 1.029 0.64
87_G 94_Q 1.028 0.64
139_H 144_S 1.02 0.63
12_I 138_A 1.015 0.63
124_N 273_S 1.013 0.63
17_A 30_Q 1.011 0.62
145_L 263_A 1 0.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1viaA20.472997.40.926Contact Map0.639
4e22A10.552397.30.926Contact Map0.583
1zuhA10.458597.30.927Contact Map0.549
2iyvA10.465797.20.928Contact Map0.487
1e6cA20.454997.10.929Contact Map0.608
2pt5A40.4477970.93Contact Map0.634
1ckeA10.4765970.93Contact Map0.566
2h92A30.4585970.93Contact Map0.639
3t61A20.50996.90.931Contact Map0.616
3fdiA20.472996.90.931Contact Map0.493
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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