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OPENSEQ.org
TRPA - Tryptophan synthase alpha chain
UniProt: P0A877 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11024
Length: 268 (264)
Sequences: 1770
Seq/Len: 6.70
TRPA
Paralog alert: 0.02 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
29_G 32_Q 3.787 1.00
27_D 70_R 3.228 1.00
109_K 117_Q 2.914 1.00
42_E 256_K 2.744 1.00
24_T 68_T 2.677 1.00
2_E 149_A 2.492 1.00
160_D 199_K 2.489 1.00
209_L 230_G 2.447 1.00
3_R 124_D 2.412 1.00
66_N 242_E 2.343 1.00
21_P 45_A 2.333 1.00
39_T 43_A 2.27 1.00
89_R 124_D 2.246 1.00
43_A 256_K 2.201 1.00
38_D 91_K 2.183 1.00
87_L 90_Q 2.158 1.00
117_Q 120_K 2.106 1.00
263_K 267_R 2.036 1.00
144_L 171_R 2.028 1.00
18_A 230_G 2.023 1.00
115_Y 143_A 1.998 1.00
154_C 163_L 1.994 1.00
34_L 87_L 1.983 1.00
80_Q 83_E 1.962 1.00
201_K 208_P 1.948 1.00
112_D 142_A 1.947 1.00
7_L 10_Q 1.904 1.00
52_I 78_P 1.887 1.00
106_V 128_V 1.88 1.00
37_I 88_I 1.852 1.00
164_R 168_S 1.843 1.00
116_A 146_H 1.821 1.00
233_S 262_M 1.816 1.00
37_I 48_L 1.789 1.00
7_L 11_L 1.772 1.00
214_I 231_A 1.77 1.00
47_A 98_G 1.735 1.00
128_V 139_F 1.719 1.00
149_A 171_R 1.696 1.00
41_I 95_I 1.658 1.00
118_C 148_V 1.61 1.00
77_T 80_Q 1.598 1.00
103_A 131_V 1.579 1.00
36_I 241_I 1.557 0.99
178_S 210_Q 1.541 0.99
113_E 117_Q 1.536 0.99
116_A 120_K 1.536 0.99
4_Y 47_A 1.53 0.99
176_L 208_P 1.514 0.99
217_P 261_P 1.511 0.99
10_Q 14_R 1.511 0.99
79_A 117_Q 1.491 0.99
76_V 80_Q 1.486 0.99
140_R 144_L 1.473 0.99
39_T 256_K 1.465 0.99
201_K 229_A 1.465 0.99
83_E 87_L 1.459 0.99
101_M 105_L 1.456 0.99
216_A 219_Q 1.436 0.99
253_A 257_V 1.43 0.99
20_V 209_L 1.424 0.99
154_C 158_A 1.424 0.99
22_F 68_T 1.404 0.99
158_A 163_L 1.404 0.99
83_E 86_A 1.391 0.99
176_L 196_L 1.391 0.99
217_P 221_K 1.387 0.98
215_S 239_K 1.381 0.98
71_A 76_V 1.378 0.98
256_K 260_Q 1.375 0.98
5_E 149_A 1.362 0.98
112_D 145_R 1.355 0.98
117_Q 121_V 1.341 0.98
113_E 116_A 1.321 0.98
143_A 150_P 1.314 0.98
103_A 111_I 1.309 0.98
198_A 202_E 1.303 0.98
101_M 106_V 1.296 0.97
257_V 261_P 1.29 0.97
30_I 34_L 1.287 0.97
16_E 263_K 1.264 0.97
79_A 83_E 1.248 0.97
220_V 266_T 1.242 0.96
209_L 232_I 1.239 0.96
118_C 123_V 1.238 0.96
163_L 200_L 1.238 0.96
157_N 180_A 1.213 0.96
210_Q 223_A 1.212 0.96
22_F 51_G 1.209 0.96
239_K 243_Q 1.206 0.96
36_I 255_L 1.201 0.95
100_L 127_L 1.194 0.95
86_A 120_K 1.192 0.95
86_A 117_Q 1.191 0.95
103_A 139_F 1.19 0.95
27_D 238_V 1.185 0.95
240_I 258_F 1.18 0.95
37_I 97_I 1.178 0.95
16_E 267_R 1.175 0.95
165_Q 168_S 1.169 0.94
195_H 198_A 1.166 0.94
30_I 76_V 1.153 0.94
27_D 242_E 1.152 0.94
194_N 198_A 1.148 0.94
260_Q 264_A 1.145 0.94
215_S 219_Q 1.139 0.93
237_I 259_V 1.132 0.93
210_Q 228_A 1.132 0.93
3_R 89_R 1.128 0.93
115_Y 142_A 1.122 0.93
170_G 206_A 1.122 0.93
258_F 261_P 1.12 0.93
179_R 186_E 1.117 0.93
136_S 152_F 1.093 0.91
115_Y 126_V 1.091 0.91
79_A 109_K 1.089 0.91
82_F 117_Q 1.089 0.91
52_I 99_L 1.089 0.91
160_D 164_R 1.075 0.91
9_A 13_E 1.074 0.90
86_A 168_S 1.069 0.90
129_A 232_I 1.063 0.90
6_S 10_Q 1.058 0.90
254_A 257_V 1.055 0.89
82_F 118_C 1.053 0.89
46_D 263_K 1.052 0.89
38_D 42_E 1.047 0.89
76_V 81_C 1.029 0.88
233_S 258_F 1.018 0.87
48_L 95_I 1.018 0.87
39_T 42_E 1.017 0.87
119_E 146_H 1.015 0.87
23_V 36_I 1.014 0.87
54_F 58_L 1.001 0.86
218_D 222_A 1 0.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1ujpA10.95151000.406Contact Map0.703
3thaA20.92911000.437Contact Map0.758
2ekcA20.97391000.458Contact Map0.783
1qopA111000.463Contact Map0.714
3vndA80.99251000.469Contact Map0.769
3navA211000.478Contact Map0.783
1rd5A20.97391000.505Contact Map0.726
1geqA20.92541000.522Contact Map0.714
3cu2A20.8061000.597Contact Map0.544
2f6uA20.72761000.641Contact Map0.501
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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