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OPENSEQ.org
GLYA - Serine hydroxymethyltransferase
UniProt: P0A825 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10408
Length: 417 (408)
Sequences: 2076
Seq/Len: 5.09
GLYA
Paralog alert: 0.16 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
159_E 192_S 4.286 1.00
187_R 191_D 4.111 1.00
163_K 192_S 3.922 1.00
76_Q 80_D 3.891 1.00
293_K 376_E 3.558 1.00
225_T 238_L 3.435 1.00
109_L 222_V 3.277 1.00
157_D 160_K 3.067 1.00
375_K 378_E 3.014 1.00
115_T 141_N 2.987 1.00
184_A 188_E 2.833 1.00
159_E 163_K 2.8 1.00
82_A 238_L 2.799 1.00
159_E 185_K 2.794 1.00
21_Q 73_I 2.789 1.00
151_G 308_K 2.673 1.00
180_V 214_P 2.611 1.00
153_I 158_L 2.599 1.00
333_A 390_L 2.579 1.00
212_V 292_A 2.552 1.00
289_Q 293_K 2.529 1.00
388_D 405_K 2.486 1.00
161_Q 165_H 2.427 1.00
300_E 304_E 2.425 1.00
179_G 315_D 2.382 1.00
381_E 405_K 2.375 1.00
290_Q 376_E 2.346 1.00
210_A 288_Q 2.304 1.00
30_I 369_I 2.286 1.00
374_F 382_L 2.285 1.00
277_K 281_E 2.279 1.00
290_Q 375_K 2.255 1.00
160_K 164_E 2.254 1.00
82_A 225_T 2.173 1.00
110_L 169_M 2.169 1.00
344_V 364_V 2.144 1.00
116_V 142_I 2.096 1.00
199_V 220_A 2.08 1.00
76_Q 79_I 2.062 1.00
143_V 165_H 2.057 1.00
115_T 165_H 2.033 1.00
80_D 84_E 2.021 1.00
377_A 380_K 1.992 1.00
392_S 395_D 1.989 1.00
18_A 74_V 1.971 1.00
241_A 245_S 1.959 1.00
18_A 73_I 1.956 1.00
91_A 240_L 1.945 1.00
327_N 354_K 1.93 1.00
369_I 379_A 1.928 1.00
157_D 161_Q 1.913 1.00
301_V 380_K 1.888 1.00
301_V 304_E 1.878 1.00
90_Y 253_N 1.874 1.00
158_L 186_M 1.868 1.00
305_R 387_C 1.864 1.00
401_R 405_K 1.827 1.00
172_G 186_M 1.816 1.00
301_V 384_G 1.799 1.00
305_R 384_G 1.79 1.00
290_Q 293_K 1.787 1.00
70_Y 73_I 1.776 1.00
389_V 402_I 1.773 1.00
21_Q 70_Y 1.763 1.00
178_S 309_V 1.753 1.00
90_Y 241_A 1.725 1.00
106_Y 171_I 1.712 1.00
307_Y 387_C 1.712 1.00
186_M 197_L 1.704 1.00
156_A 185_K 1.701 1.00
115_T 143_V 1.694 1.00
17_Q 21_Q 1.67 0.99
378_E 413_Y 1.67 0.99
300_E 380_K 1.657 0.99
221_H 245_S 1.657 0.99
385_W 402_I 1.648 0.99
204_V 213_Y 1.64 0.99
47_Q 268_V 1.634 0.99
51_L 71_V 1.608 0.99
88_A 217_V 1.59 0.99
15_L 74_V 1.588 0.99
24_V 28_E 1.578 0.99
301_V 383_A 1.578 0.99
84_E 280_M 1.563 0.99
381_E 385_W 1.528 0.99
28_E 407_L 1.513 0.99
326_K 391_D 1.513 0.99
155_Y 185_K 1.506 0.99
32_L 369_I 1.502 0.99
295_A 314_T 1.498 0.99
298_M 383_A 1.495 0.99
212_V 289_Q 1.492 0.98
23_K 27_E 1.491 0.98
104_A 256_V 1.489 0.98
297_A 301_V 1.473 0.98
296_K 300_E 1.446 0.98
339_R 399_I 1.436 0.98
308_K 325_D 1.436 0.98
122_A 348_S 1.426 0.98
40_S 278_E 1.414 0.98
18_A 70_Y 1.4 0.97
324_V 354_K 1.396 0.97
16_W 20_E 1.392 0.97
108_A 255_A 1.379 0.97
148_D 154_D 1.37 0.97
305_R 388_D 1.368 0.97
184_A 219_H 1.363 0.97
169_M 198_F 1.361 0.97
294_N 370_T 1.346 0.97
103_F 135_F 1.338 0.96
303_L 312_G 1.337 0.96
201_M 240_L 1.334 0.96
185_K 188_E 1.33 0.96
369_I 382_L 1.322 0.96
299_V 319_F 1.318 0.96
285_K 289_Q 1.309 0.96
15_L 274_V 1.307 0.96
204_V 316_N 1.303 0.96
103_F 260_G 1.298 0.96
241_A 249_Y 1.295 0.95
308_K 322_D 1.292 0.95
286_T 289_Q 1.29 0.95
298_M 379_A 1.287 0.95
89_D 245_S 1.282 0.95
85_L 279_A 1.28 0.95
212_V 288_Q 1.274 0.95
29_H 338_G 1.262 0.95
163_K 166_K 1.256 0.94
385_W 405_K 1.252 0.94
398_V 402_I 1.236 0.94
90_Y 252_L 1.227 0.93
341_N 407_L 1.226 0.93
119_M 146_G 1.224 0.93
99_S 128_T 1.221 0.93
111_E 114_D 1.22 0.93
11_Y 277_K 1.218 0.93
248_L 251_K 1.216 0.93
153_I 181_V 1.215 0.93
211_G 285_K 1.214 0.93
47_Q 271_G 1.211 0.93
51_L 74_V 1.211 0.93
38_Y 415_V 1.208 0.93
213_Y 316_N 1.203 0.93
387_C 391_D 1.199 0.92
298_M 302_F 1.188 0.92
110_L 116_V 1.188 0.92
302_F 387_C 1.187 0.92
174_F 181_V 1.184 0.92
308_K 349_V 1.184 0.92
143_V 161_Q 1.181 0.92
82_A 276_L 1.181 0.92
400_E 404_G 1.178 0.92
340_A 389_V 1.174 0.91
91_A 238_L 1.168 0.91
141_N 165_H 1.166 0.91
198_F 224_T 1.163 0.91
89_D 241_A 1.162 0.91
159_E 188_E 1.152 0.90
398_V 401_R 1.152 0.90
225_T 276_L 1.148 0.90
109_L 196_Y 1.136 0.89
90_Y 249_Y 1.134 0.89
302_F 383_A 1.131 0.89
407_L 411_A 1.13 0.89
308_K 312_G 1.128 0.89
221_H 248_L 1.123 0.89
301_V 305_R 1.118 0.88
172_G 199_V 1.118 0.88
148_D 157_D 1.104 0.88
299_V 309_V 1.102 0.87
381_E 412_R 1.101 0.87
309_V 319_F 1.099 0.87
238_L 276_L 1.09 0.87
71_V 266_M 1.089 0.87
29_H 341_N 1.082 0.86
337_L 344_V 1.077 0.86
15_L 77_L 1.072 0.85
56_A 266_M 1.072 0.85
119_M 181_V 1.072 0.85
232_A 371_R 1.069 0.85
89_D 246_E 1.066 0.85
404_G 408_D 1.062 0.85
279_A 284_F 1.051 0.84
307_Y 321_V 1.05 0.84
147_I 351_N 1.049 0.84
187_R 221_H 1.047 0.84
110_L 114_D 1.043 0.83
120_N 144_P 1.041 0.83
105_V 222_V 1.036 0.83
332_E 394_N 1.035 0.83
90_Y 245_S 1.032 0.82
307_Y 326_K 1.027 0.82
256_V 260_G 1.024 0.82
15_L 18_A 1.019 0.81
385_W 409_I 1.019 0.81
174_F 204_V 1.016 0.81
364_V 386_M 1.016 0.81
297_A 380_K 1.011 0.81
31_E 343_T 1.01 0.80
384_G 388_D 1.01 0.80
180_V 213_Y 1.004 0.80
66_G 334_D 1.003 0.80
221_H 246_E 1.002 0.80
109_L 248_L 1.002 0.80
293_K 296_K 1.001 0.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1rv3A20.98561000.461Contact Map0.749
2a7vA10.98561000.492Contact Map0.718
3h7fA20.98561000.592Contact Map0.719
4j5uA20.9881000.631Contact Map0.754
3n0lA20.9881000.632Contact Map0.786
3gbxA20.99281000.639Contact Map0.817
3ecdA40.98561000.644Contact Map0.738
2dkjA20.97121000.652Contact Map0.85
2vi8A10.96881000.664Contact Map0.71
3b46A20.88731000.735Contact Map0.449
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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