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OPENSEQ.org
SFSA - Sugar fermentation stimulation protein A
UniProt: P0A823 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10949
Length: 234 (234)
Sequences: 747
Seq/Len: 3.19
SFSA
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
154_T 157_G 4.221 1.00
90_K 109_S 3.583 1.00
173_R 211_E 3.396 1.00
93_I 122_F 3.384 1.00
36_P 66_T 3.177 1.00
192_R 199_A 3.069 1.00
89_T 177_F 2.916 1.00
23_V 53_Y 2.574 1.00
114_G 163_E 2.515 1.00
23_V 51_V 2.5 1.00
158_Q 201_L 2.462 1.00
192_R 203_S 2.446 1.00
90_K 94_L 2.257 1.00
24_I 30_E 2.222 1.00
21_A 35_C 2.036 1.00
9_R 50_T 1.978 1.00
25_T 31_L 1.937 1.00
52_W 77_F 1.922 1.00
79_C 181_L 1.902 0.99
214_A 232_V 1.892 0.99
169_A 208_R 1.886 0.99
50_T 71_Q 1.878 0.99
188_F 232_V 1.802 0.99
199_A 203_S 1.781 0.99
180_V 230_L 1.69 0.98
1_M 91_E 1.678 0.98
111_V 133_Y 1.677 0.98
143_E 193_H 1.647 0.98
125_Q 131_D 1.636 0.98
191_A 194_I 1.628 0.98
51_V 67_W 1.628 0.98
202_L 212_I 1.619 0.98
118_S 163_E 1.615 0.98
8_Q 53_Y 1.611 0.98
167_V 172_Q 1.605 0.98
133_Y 167_V 1.59 0.98
10_A 51_V 1.563 0.97
10_A 23_V 1.514 0.96
165_M 201_L 1.497 0.96
84_W 87_R 1.491 0.96
104_Y 132_C 1.476 0.96
44_C 70_T 1.471 0.96
85_A 138_S 1.452 0.95
162_R 204_E 1.45 0.95
133_Y 172_Q 1.444 0.95
134_I 177_F 1.422 0.94
40_A 43_G 1.41 0.94
61_R 66_T 1.408 0.94
147_G 188_F 1.375 0.93
181_L 217_A 1.371 0.93
148_Y 188_F 1.371 0.93
89_T 93_I 1.37 0.93
109_S 122_F 1.367 0.93
33_L 53_Y 1.365 0.93
55_T 64_P 1.36 0.92
175_V 213_L 1.357 0.92
131_D 172_Q 1.354 0.92
205_A 210_V 1.324 0.91
197_K 200_Q 1.32 0.91
89_T 179_A 1.314 0.91
113_Y 120_I 1.31 0.91
176_I 188_F 1.307 0.90
148_Y 193_H 1.269 0.89
113_Y 167_V 1.269 0.89
166_S 169_A 1.263 0.88
13_I 30_E 1.26 0.88
33_L 63_Y 1.252 0.88
79_C 138_S 1.246 0.87
117_R 163_E 1.229 0.86
49_D 70_T 1.219 0.86
182_H 185_I 1.216 0.86
16_Y 22_D 1.216 0.86
96_E 103_G 1.198 0.84
68_E 81_N 1.195 0.84
11_T 24_I 1.193 0.84
161_L 176_I 1.192 0.84
100_E 229_S 1.191 0.84
206_Q 212_I 1.191 0.84
132_C 175_V 1.174 0.83
152_A 194_I 1.17 0.82
146_Q 187_R 1.167 0.82
188_F 214_A 1.164 0.82
140_T 152_A 1.145 0.81
190_P 202_L 1.137 0.80
54_S 68_E 1.137 0.80
141_L 194_I 1.135 0.80
158_Q 195_D 1.132 0.79
14_Q 22_D 1.129 0.79
165_M 168_A 1.116 0.78
180_V 214_A 1.109 0.78
89_T 122_F 1.104 0.77
35_C 67_W 1.104 0.77
31_L 65_H 1.1 0.77
31_L 53_Y 1.1 0.77
22_D 32_T 1.096 0.76
12_L 21_A 1.096 0.76
196_E 200_Q 1.089 0.76
10_A 53_Y 1.087 0.76
142_A 185_I 1.082 0.75
54_S 81_N 1.081 0.75
165_M 205_A 1.081 0.75
100_E 215_Y 1.075 0.74
114_G 118_S 1.072 0.74
52_W 71_Q 1.054 0.72
33_L 67_W 1.034 0.70
104_Y 124_L 1.026 0.69
87_R 109_S 1.024 0.69
81_N 85_A 1.018 0.68
111_V 118_S 1.017 0.68
147_G 182_H 1.013 0.68
117_R 120_I 1.002 0.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4dapA10.99571000.003Contact Map0.802
1jt8A10.367553.60.953Contact Map0.43
2oqkA10.380349.80.954Contact Map0.537
2eo0A20.576932.80.959Contact Map0.546
2ostA40.54727.70.96Contact Map0.321
3e59A40.632525.10.961Contact Map0.268
3i10A10.299121.80.962Contact Map0.118
2dgyA10.423120.60.963Contact Map0.647
2vldA20.8376160.965Contact Map0.378
2d1pB30.397415.20.965Contact Map0.257
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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