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OPENSEQ.org
METK - S-adenosylmethionine synthase
UniProt: P0A817 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10589
Length: 384 (383)
Sequences: 1620
Seq/Len: 4.23
METK
Paralog alert: 0.06 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
129_N 293_D 6.231 1.00
45_Y 54_G 3.931 1.00
74_R 87_A 3.767 1.00
31_I 38_A 3.633 1.00
172_Q 180_G 3.478 1.00
146_V 167_S 3.454 1.00
319_E 323_S 3.327 1.00
257_R 296_E 2.93 1.00
12_S 165_A 2.845 1.00
67_E 71_N 2.745 1.00
186_L 203_V 2.735 1.00
75_E 353_K 2.735 1.00
30_A 33_E 2.661 1.00
293_D 320_K 2.634 1.00
300_S 309_T 2.598 1.00
160_W 202_A 2.537 1.00
148_R 151_E 2.53 1.00
133_V 140_T 2.491 1.00
307_E 331_R 2.464 1.00
134_L 371_T 2.463 1.00
196_Q 200_Q 2.434 1.00
205_E 209_K 2.379 1.00
329_L 333_F 2.379 1.00
42_C 57_I 2.375 1.00
74_R 88_N 2.357 1.00
102_D 230_R 2.325 1.00
182_D 222_K 2.288 1.00
180_G 218_T 2.258 1.00
184_V 212_L 2.249 1.00
233_I 238_G 2.23 1.00
268_P 352_Y 2.212 1.00
371_T 374_A 2.195 1.00
328_L 332_E 2.185 1.00
20_A 46_V 2.173 1.00
217_L 223_F 2.139 1.00
53_V 69_T 2.136 1.00
147_Q 151_E 2.12 1.00
151_E 155_N 2.12 1.00
5_L 170_T 2.104 1.00
39_R 108_D 2.087 1.00
34_Q 61_A 2.085 1.00
53_V 65_I 2.074 1.00
37_K 348_L 2.074 1.00
31_I 59_T 2.009 1.00
325_Q 328_L 1.988 1.00
19_I 76_I 1.961 1.00
79_V 83_M 1.954 1.00
137_A 141_Y 1.941 1.00
286_I 295_C 1.937 1.00
346_D 349_H 1.929 1.00
72_T 353_K 1.899 1.00
195_D 198_S 1.89 1.00
278_A 336_L 1.857 1.00
115_Q 269_S 1.854 1.00
183_A 224_F 1.851 1.00
204_M 209_K 1.82 1.00
198_S 202_A 1.776 1.00
354_E 366_F 1.76 0.99
26_A 68_I 1.753 0.99
181_I 212_L 1.74 0.99
26_A 353_K 1.737 0.99
12_S 146_V 1.709 0.99
145_L 186_L 1.695 0.99
46_V 51_V 1.678 0.99
45_Y 52_L 1.677 0.99
321_V 329_L 1.656 0.99
355_T 366_F 1.633 0.99
105_Q 228_T 1.628 0.99
47_K 97_G 1.627 0.99
296_E 316_F 1.622 0.99
313_V 330_V 1.615 0.99
279_A 299_V 1.601 0.99
38_A 60_S 1.589 0.99
281_Y 372_D 1.576 0.99
104_N 108_D 1.56 0.98
201_E 205_E 1.55 0.98
321_V 325_Q 1.542 0.98
282_V 336_L 1.537 0.98
146_V 165_A 1.524 0.98
63_V 68_I 1.523 0.98
332_E 380_A 1.522 0.98
64_D 67_E 1.52 0.98
144_R 147_Q 1.508 0.98
333_F 380_A 1.505 0.98
22_Q 26_A 1.5 0.98
157_T 206_E 1.486 0.98
322_P 325_Q 1.481 0.98
333_F 374_A 1.464 0.97
139_I 143_H 1.458 0.97
148_R 210_P 1.451 0.97
51_V 73_V 1.447 0.97
337_R 340_G 1.442 0.97
340_G 344_M 1.433 0.97
200_Q 204_M 1.42 0.97
355_T 361_F 1.404 0.96
281_Y 344_M 1.399 0.96
126_Y 255_M 1.398 0.96
79_V 87_A 1.398 0.96
13_E 358_Y 1.392 0.96
218_T 221_T 1.385 0.96
286_I 292_A 1.38 0.96
291_L 377_L 1.369 0.96
354_E 367_P 1.351 0.95
72_T 75_E 1.351 0.95
50_M 91_A 1.338 0.95
152_V 165_A 1.331 0.95
19_I 73_V 1.33 0.95
378_R 381_A 1.324 0.95
375_Q 379_D 1.316 0.94
50_M 93_L 1.315 0.94
22_Q 72_T 1.314 0.94
71_N 74_R 1.308 0.94
134_L 288_A 1.282 0.93
208_I 223_F 1.282 0.93
187_S 227_P 1.281 0.93
278_A 281_Y 1.275 0.93
329_L 380_A 1.271 0.93
60_S 101_P 1.262 0.92
333_F 376_L 1.254 0.92
54_G 240_C 1.248 0.92
26_A 72_T 1.248 0.92
376_L 379_D 1.248 0.92
269_S 348_L 1.241 0.92
319_E 326_L 1.241 0.92
13_E 150_A 1.239 0.92
329_L 381_A 1.238 0.92
106_G 228_T 1.237 0.91
80_H 83_M 1.236 0.91
339_Y 343_Q 1.236 0.91
172_Q 218_T 1.231 0.91
177_K 293_D 1.227 0.91
71_N 75_E 1.218 0.91
171_F 181_I 1.212 0.90
24_S 44_T 1.203 0.90
147_Q 366_F 1.201 0.90
286_I 330_V 1.201 0.90
27_V 42_C 1.2 0.90
373_K 376_L 1.188 0.89
202_A 206_E 1.187 0.89
278_A 282_V 1.182 0.89
286_I 291_L 1.181 0.89
183_A 222_K 1.179 0.89
197_K 200_Q 1.174 0.88
257_R 316_F 1.172 0.88
278_A 344_M 1.168 0.88
329_L 377_L 1.162 0.88
378_R 382_G 1.159 0.88
149_Q 165_A 1.158 0.87
75_E 154_K 1.157 0.87
344_M 373_K 1.152 0.87
129_N 320_K 1.14 0.86
150_A 358_Y 1.137 0.86
203_V 225_I 1.134 0.86
255_M 294_R 1.126 0.85
28_L 40_V 1.116 0.85
19_I 46_V 1.109 0.84
102_D 106_G 1.106 0.84
30_A 68_I 1.094 0.83
22_Q 356_A 1.093 0.83
45_Y 240_C 1.091 0.83
19_I 23_I 1.089 0.83
286_I 377_L 1.085 0.82
314_E 323_S 1.083 0.82
150_A 154_K 1.083 0.82
213_P 216_W 1.082 0.82
73_V 90_C 1.08 0.82
49_G 91_A 1.072 0.81
105_Q 230_R 1.069 0.81
12_S 149_Q 1.068 0.81
329_L 374_A 1.058 0.80
31_I 57_I 1.052 0.80
20_A 45_Y 1.049 0.79
62_W 98_K 1.047 0.79
58_T 101_P 1.045 0.79
194_I 199_L 1.044 0.79
31_I 63_V 1.043 0.79
102_D 232_V 1.026 0.77
62_W 65_I 1.024 0.77
206_E 210_P 1.021 0.77
321_V 326_L 1.018 0.76
101_P 105_Q 1.014 0.76
197_K 201_E 1.013 0.76
52_L 91_A 1.011 0.76
113_L 339_Y 1.01 0.76
140_T 144_R 1.002 0.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3s82A20.99221000.005Contact Map0.747
3so4A411000.012Contact Map0.724
3imlA411000.055Contact Map0.801
1p7lA40.99741000.057Contact Map0.757
2p02A10.97921000.069Contact Map0.725
4l7iA20.867298.30.948Contact Map0.399
2ogkA40.179726.70.983Contact Map0.326
1csnA10.179715.20.985Contact Map0.209
3qe2A20.302114.90.985Contact Map0.189
2fmmE10.12511.80.985Contact Map0.436
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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