May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
RUVC - Crossover junction endodeoxyribonuclease RuvC
UniProt: P0A814 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10925
Length: 173 (162)
Sequences: 1264
Seq/Len: 7.80
RUVC
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
107_V 146_I 3.824 1.00
64_F 92_A 3.754 1.00
3_I 20_R 3.1 1.00
102_Y 150_H 2.992 1.00
105_R 116_S 2.908 1.00
126_V 148_I 2.905 1.00
57_T 95_Q 2.765 1.00
28_Y 31_S 2.715 1.00
26_L 148_I 2.552 1.00
17_G 144_L 2.452 1.00
4_I 151_C 2.391 1.00
132_L 136_P 2.383 1.00
53_T 94_N 2.196 1.00
40_D 43_S 2.149 1.00
46_K 50_A 2.138 1.00
20_R 27_S 1.981 1.00
63_Y 154_S 1.899 1.00
103_A 106_Q 1.879 1.00
49_Y 91_A 1.867 1.00
3_I 29_L 1.8 1.00
20_R 29_L 1.75 1.00
79_L 82_G 1.716 1.00
49_Y 94_N 1.64 1.00
123_Q 141_A 1.579 1.00
87_V 90_V 1.564 1.00
13_V 35_R 1.556 1.00
85_R 101_E 1.537 1.00
65_A 146_I 1.476 0.99
54_E 58_Q 1.455 0.99
11_S 80_K 1.443 0.99
51_G 54_E 1.419 0.99
124_H 128_T 1.397 0.99
21_Q 26_L 1.376 0.99
127_R 135_N 1.356 0.99
72_A 78_A 1.353 0.99
7_I 88_A 1.329 0.98
5_L 56_I 1.323 0.98
1_M 137_Q 1.297 0.98
46_K 93_V 1.282 0.98
41_L 83_Q 1.276 0.98
46_K 94_N 1.272 0.98
124_H 127_R 1.254 0.98
28_Y 144_L 1.247 0.97
13_V 139_D 1.239 0.97
5_L 18_V 1.226 0.97
33_C 140_A 1.221 0.97
136_P 141_A 1.21 0.97
121_Q 125_M 1.207 0.97
7_I 52_V 1.206 0.97
45_L 87_V 1.204 0.97
46_K 96_E 1.195 0.96
50_A 94_N 1.185 0.96
49_Y 90_V 1.157 0.96
71_M 81_L 1.156 0.95
90_V 94_N 1.156 0.95
73_K 76_D 1.152 0.95
16_Y 32_G 1.149 0.95
148_I 152_H 1.149 0.95
19_I 144_L 1.137 0.95
5_L 64_F 1.132 0.95
48_I 88_A 1.13 0.95
74_N 77_S 1.125 0.95
110_T 149_T 1.118 0.94
22_V 25_Q 1.115 0.94
138_A 141_A 1.106 0.94
31_S 140_A 1.099 0.94
102_Y 149_T 1.081 0.93
16_Y 51_G 1.065 0.92
30_G 59_F 1.063 0.92
106_Q 110_T 1.058 0.92
89_I 93_V 1.05 0.91
53_T 95_Q 1.046 0.91
18_V 55_I 1.042 0.91
63_Y 150_H 1.03 0.90
16_Y 30_G 1.022 0.90
47_L 51_G 1.017 0.90
125_M 129_L 1.014 0.89
11_S 36_T 1.005 0.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1hjrA40.91331000.176Contact Map0.837
4ep4A20.93061000.253Contact Map0.829
4ktwA20.84391000.266Contact Map0.503
1vhxA20.826699.90.628Contact Map0.375
1nu0A20.757299.90.638Contact Map0.398
1iv0A10.554999.70.715Contact Map0.319
1kcfA20.953896.50.888Contact Map0.594
3psiA10.965394.40.903Contact Map0.539
3bzcA10.832494.10.905Contact Map0.565
3psfA10.965393.60.906Contact Map0.535
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 0.0279 seconds.