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OPENSEQ.org

RUVA - Holliday junction ATP-dependent DNA helicase RuvA
UniProt: P0A809 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10923
Length: 203 (200)
Sequences: 1690
Seq/Len: 8.45

RUVA
Paralog alert: 0.00 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
51_F 58_Q 3.863 1.00
6_R 44_E 3.505 1.00
5_L 28_V 3.073 1.00
190_S 193_T 3.022 1.00
50_H 73_K 2.95 1.00
53_V 58_Q 2.777 1.00
9_I 45_A 2.475 1.00
93_M 101_A 2.401 1.00
11_E 66_K 2.368 1.00
5_L 21_V 2.367 1.00
118_K 122_E 2.231 1.00
17_V 30_M 2.199 1.00
6_R 46_I 2.161 1.00
164_V 181_V 2.103 1.00
163_A 195_I 2.062 1.00
180_M 202_A 2.012 1.00
107_V 125_I 1.942 1.00
4_R 46_I 1.941 1.00
85_L 116_I 1.937 1.00
6_R 20_E 1.88 1.00
106_E 109_A 1.86 1.00
50_H 76_I 1.841 1.00
3_G 18_L 1.79 1.00
165_A 169_A 1.78 1.00
123_R 127_E 1.776 1.00
5_L 19_I 1.718 1.00
40_E 43_Q 1.716 1.00
30_M 35_F 1.711 1.00
105_E 129_K 1.652 1.00
163_A 194_L 1.633 1.00
4_R 10_I 1.633 1.00
5_L 24_V 1.629 1.00
105_E 122_E 1.599 1.00
74_E 132_F 1.59 1.00
19_I 28_V 1.581 1.00
31_P 34_C 1.56 1.00
89_I 113_L 1.558 1.00
16_L 27_E 1.547 1.00
28_V 49_T 1.526 1.00
34_C 47_V 1.522 1.00
107_V 122_E 1.52 1.00
8_I 44_E 1.497 1.00
30_M 34_C 1.496 1.00
69_R 73_K 1.469 0.99
31_P 68_E 1.448 0.99
3_G 69_R 1.434 0.99
20_E 46_I 1.404 0.99
19_I 45_A 1.399 0.99
81_V 124_L 1.399 0.99
103_E 130_D 1.382 0.99
111_V 118_K 1.372 0.99
94_S 97_Q 1.369 0.99
98_F 102_V 1.35 0.99
17_V 47_V 1.33 0.99
52_V 59_L 1.312 0.99
100_N 104_R 1.311 0.99
173_K 176_E 1.292 0.98
183_K 201_A 1.283 0.98
116_I 120_T 1.279 0.98
88_A 113_L 1.279 0.98
48_F 66_K 1.273 0.98
174_P 178_S 1.27 0.98
93_M 109_A 1.241 0.98
17_V 38_L 1.239 0.98
9_I 19_I 1.198 0.97
108_G 111_V 1.198 0.97
85_L 120_T 1.189 0.97
13_Q 16_L 1.176 0.97
81_V 85_L 1.163 0.96
9_I 39_P 1.162 0.96
10_I 20_E 1.161 0.96
71_L 132_F 1.156 0.96
168_V 177_A 1.156 0.96
85_L 88_A 1.138 0.96
53_V 57_A 1.13 0.95
89_I 98_F 1.13 0.95
30_M 47_V 1.126 0.95
52_V 57_A 1.124 0.95
18_L 25_G 1.119 0.95
115_G 123_R 1.113 0.95
20_E 24_V 1.113 0.95
68_E 95_A 1.106 0.95
93_M 113_L 1.101 0.95
31_P 91_S 1.1 0.95
164_V 177_A 1.05 0.93
79_N 85_L 1.049 0.92
81_V 113_L 1.049 0.92
4_R 20_E 1.034 0.92
88_A 92_G 1.034 0.92
93_M 98_F 1.02 0.91
85_L 113_L 1.018 0.91
177_A 184_I 1.018 0.91
2_I 49_T 1.009 0.90
12_K 35_F 1.005 0.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2ztdA20.94091000.238Contact Map0.802
1cukA10.99511000.241Contact Map0.701
1ixrA20.9311000.242Contact Map0.822
3b0xA10.906499.80.675Contact Map0.294
4bxoA10.719299.40.753Contact Map0.357
2w9mA20.916399.40.757Contact Map0.252
2csbA20.852299.30.764Contact Map0.578
4gfjA10.916399.10.783Contact Map0.528
1kftA10.384298.40.834Contact Map0.604
1dgsA20.911398.30.835Contact Map0.402

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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