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OPENSEQ.org
RPIA - Ribose-5-phosphate isomerase A
UniProt: P0A7Z0 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11443
Length: 219 (218)
Sequences: 1306
Seq/Len: 5.99
RPIA
Paralog alert: 0.06 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
98_A 160_V 5.561 1.00
87_N 91_Q 3.635 1.00
13_A 16_Q 3.586 1.00
178_D 181_A 3.566 1.00
147_L 186_I 3.14 1.00
79_Y 110_A 3.028 1.00
75_S 111_E 3.006 1.00
117_A 208_I 2.846 1.00
144_A 169_L 2.845 1.00
183_E 195_V 2.802 1.00
23_I 76_L 2.553 1.00
38_A 41_T 2.476 1.00
86_I 117_A 2.399 1.00
36_I 56_S 2.392 1.00
12_W 38_A 2.39 1.00
35_F 80_V 2.314 1.00
85_E 127_G 2.186 1.00
51_S 57_T 2.167 1.00
146_Q 149_K 2.097 1.00
24_V 78_I 2.07 1.00
86_I 92_M 2.066 1.00
28_T 99_A 2.044 1.00
10_V 207_L 2.009 1.00
26_V 60_L 1.86 1.00
57_T 61_K 1.852 1.00
90_M 206_A 1.8 1.00
112_K 205_V 1.788 1.00
37_D 59_K 1.781 1.00
49_A 65_I 1.762 1.00
187_N 195_V 1.747 1.00
184_N 188_A 1.746 1.00
86_I 206_A 1.694 1.00
96_G 129_F 1.659 1.00
4_D 34_H 1.651 1.00
88_G 124_D 1.619 1.00
92_M 115_C 1.559 0.99
142_A 190_P 1.542 0.99
181_A 185_A 1.534 0.99
207_L 214_V 1.53 0.99
101_T 136_I 1.525 0.99
2_T 5_E 1.509 0.99
210_T 215_K 1.492 0.99
102_R 164_N 1.456 0.99
136_I 193_V 1.435 0.99
15_L 42_M 1.338 0.97
24_V 46_I 1.338 0.97
187_N 190_P 1.336 0.97
70_L 109_V 1.33 0.97
186_I 192_V 1.311 0.97
35_F 39_L 1.31 0.97
79_Y 113_F 1.295 0.97
8_K 12_W 1.293 0.97
54_D 57_T 1.29 0.97
54_D 58_E 1.288 0.97
152_G 171_V 1.287 0.97
77_G 111_E 1.264 0.96
6_L 119_A 1.264 0.96
6_L 211_P 1.238 0.95
117_A 206_A 1.22 0.95
68_F 73_V 1.215 0.95
12_W 41_T 1.214 0.95
135_V 169_L 1.21 0.95
33_A 55_A 1.209 0.95
52_S 106_I 1.207 0.95
35_F 116_I 1.205 0.94
119_A 211_P 1.188 0.94
161_V 167_V 1.183 0.94
58_E 62_S 1.167 0.93
52_S 79_Y 1.158 0.93
11_G 15_L 1.154 0.93
32_A 35_F 1.149 0.92
125_I 177_L 1.148 0.92
140_R 144_A 1.148 0.92
60_L 67_V 1.144 0.92
161_V 165_G 1.144 0.92
133_V 171_V 1.135 0.92
32_A 51_S 1.13 0.92
122_Q 208_I 1.124 0.91
98_A 168_I 1.118 0.91
186_I 195_V 1.116 0.91
183_E 187_N 1.114 0.91
15_L 38_A 1.099 0.90
8_K 34_H 1.098 0.90
15_L 35_F 1.09 0.90
119_A 122_Q 1.09 0.90
28_T 52_S 1.079 0.89
20_P 45_Q 1.078 0.89
102_R 138_M 1.076 0.89
145_R 148_V 1.074 0.89
86_I 122_Q 1.059 0.88
80_V 116_I 1.055 0.87
100_L 168_I 1.05 0.87
11_G 28_T 1.049 0.87
17_Y 114_I 1.048 0.87
142_A 146_Q 1.045 0.87
17_Y 78_I 1.038 0.86
210_T 213_G 1.027 0.86
22_T 78_I 1.024 0.85
91_Q 180_I 1.013 0.84
144_A 148_V 1.005 0.84
40_G 63_L 1.001 0.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2f8mA20.99091000.188Contact Map0.83
3hheA20.99091000.201Contact Map0.804
1xtzA10.99091000.203Contact Map0.79
1lk5A40.99091000.206Contact Map0.868
1o8bA211000.208Contact Map0.75
3uw1A111000.211Contact Map0.732
1uj6A10.98631000.214Contact Map0.737
1m0sA20.99541000.214Contact Map0.879
4gmkA20.99091000.216Contact Map0.877
4io1A20.99541000.222Contact Map0.902
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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