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OPENSEQ.org

RNPA - Ribonuclease P protein component
UniProt: P0A7Y8 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10862
Length: 119 (112)
Sequences: 1329
Seq/Len: 11.87

RNPA
Paralog alert: 0.00 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
46_R 84_D 3.73 1.00
64_R 68_L 3.185 1.00
71_E 75_L 3.1 1.00
63_N 66_K 3.009 1.00
49_L 69_T 2.959 1.00
71_E 74_R 2.813 1.00
97_D 100_A 2.618 1.00
66_K 70_R 2.387 1.00
51_V 65_I 2.119 1.00
47_I 73_F 2.044 1.00
18_F 48_G 1.985 1.00
59_A 63_N 1.917 1.00
15_P 19_T 1.903 1.00
87_V 105_L 1.868 1.00
76_R 106_E 1.81 1.00
30_T 104_A 1.775 1.00
76_R 102_S 1.764 1.00
32_Q 96_L 1.703 1.00
14_T 17_Q 1.601 1.00
68_L 101_L 1.49 1.00
32_Q 104_A 1.454 1.00
30_T 107_K 1.444 1.00
28_A 37_G 1.439 1.00
29_G 90_K 1.404 0.99
49_L 73_F 1.373 0.99
10_L 77_Q 1.351 0.99
72_S 98_N 1.342 0.99
12_L 21_V 1.309 0.99
40_N 84_D 1.308 0.99
20_F 38_R 1.296 0.99
36_L 88_V 1.265 0.99
68_L 72_S 1.257 0.99
27_R 34_T 1.252 0.99
58_R 61_E 1.247 0.99
68_L 98_N 1.236 0.98
21_V 86_V 1.236 0.98
96_L 104_A 1.235 0.98
98_N 102_S 1.215 0.98
102_S 106_E 1.209 0.98
22_F 50_T 1.179 0.98
37_G 83_M 1.161 0.97
75_L 102_S 1.144 0.97
10_L 44_H 1.143 0.97
39_L 83_M 1.117 0.96
25_P 38_R 1.081 0.95
30_T 108_L 1.068 0.95
69_T 87_V 1.055 0.95
61_E 95_D 1.041 0.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2ljpA111000.05Contact Map0.446
1nz0A40.94961000.099Contact Map0.893
1d6tA10.9581000.122Contact Map0.596
1a6fA10.96641000.125Contact Map0.853
2bx2L10.873931.70.894Contact Map0.387
2j5aA10.38666.90.922Contact Map0.596
4bqmA20.3955.20.926Contact Map0.662
1cqmA20.33615.10.927Contact Map0.76
3r3tA20.35294.40.929Contact Map0.726
4glwA20.42861.90.941Contact Map0.099

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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