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OPENSEQ.org

RNC - Ribonuclease 3
UniProt: P0A7Y0 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10857
Length: 226 (219)
Sequences: 2249
Seq/Len: 10.27

RNC
Paralog alert: 0.05 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
54_N 133_E 3.697 1.00
15_Y 127_S 2.829 1.00
101_L 106_F 2.785 1.00
10_Q 20_Q 2.689 1.00
86_R 109_E 2.68 1.00
54_N 58_H 2.58 1.00
89_E 92_E 2.497 1.00
37_N 115_T 2.46 1.00
17_F 23_L 2.434 1.00
46_S 49_S 2.386 1.00
51_V 136_I 2.319 1.00
47_I 50_Y 2.306 1.00
177_V 191_H 2.172 1.00
214_A 217_E 2.168 1.00
176_V 190_I 2.073 1.00
49_S 53_A 2.041 1.00
175_L 193_Q 2.026 1.00
181_G 184_H 2.02 1.00
175_L 191_H 1.986 1.00
86_R 107_R 1.963 1.00
155_D 158_T 1.959 1.00
190_I 211_A 1.933 1.00
30_R 38_E 1.917 1.00
131_T 134_K 1.878 1.00
123_V 135_L 1.845 1.00
84_L 116_V 1.828 1.00
130_Q 133_E 1.815 1.00
10_Q 17_F 1.785 1.00
191_H 199_E 1.783 1.00
85_A 112_L 1.775 1.00
187_E 204_T 1.765 1.00
134_K 138_N 1.757 1.00
201_V 218_Q 1.737 1.00
179_V 186_Q 1.713 1.00
87_E 143_R 1.658 1.00
53_A 72_R 1.65 1.00
94_L 115_T 1.65 1.00
90_L 119_L 1.647 1.00
183_A 186_Q 1.634 1.00
217_E 221_K 1.627 1.00
194_V 200_P 1.578 1.00
55_A 59_R 1.551 1.00
27_L 90_L 1.548 1.00
78_G 113_A 1.543 1.00
59_R 145_D 1.54 1.00
17_F 126_D 1.523 1.00
189_T 202_V 1.493 1.00
120_I 135_L 1.489 1.00
178_Q 189_T 1.483 1.00
116_V 120_I 1.441 1.00
157_K 212_E 1.436 1.00
32_A 95_R 1.427 1.00
191_H 202_V 1.424 1.00
46_S 72_R 1.408 1.00
83_E 143_R 1.4 0.99
161_Q 174_Y 1.375 0.99
128_D 131_T 1.365 0.99
205_G 214_A 1.351 0.99
193_Q 199_E 1.347 0.99
210_K 214_A 1.335 0.99
100_E 105_G 1.326 0.99
137_L 141_Q 1.318 0.99
156_P 213_Q 1.316 0.99
12_K 89_E 1.303 0.99
201_V 219_A 1.298 0.99
135_L 139_W 1.296 0.99
189_T 204_T 1.295 0.99
10_Q 15_Y 1.292 0.99
63_V 67_D 1.29 0.99
85_A 116_V 1.283 0.99
115_T 118_A 1.267 0.99
156_P 217_E 1.248 0.99
10_Q 16_T 1.244 0.98
192_C 201_V 1.243 0.98
180_R 187_E 1.234 0.98
77_R 80_T 1.231 0.98
27_L 115_T 1.23 0.98
30_R 37_N 1.226 0.98
132_V 136_I 1.226 0.98
203_G 215_A 1.215 0.98
41_E 45_D 1.209 0.98
9_L 93_C 1.205 0.98
24_Q 95_R 1.204 0.98
86_R 112_L 1.201 0.98
127_S 131_T 1.191 0.98
55_A 137_L 1.167 0.97
185_D 206_S 1.163 0.97
133_E 137_L 1.161 0.97
180_R 189_T 1.151 0.97
82_A 86_R 1.145 0.97
39_R 43_L 1.131 0.97
91_G 112_L 1.131 0.97
206_S 210_K 1.126 0.97
12_K 93_C 1.118 0.96
160_L 192_C 1.118 0.96
15_Y 18_N 1.118 0.96
121_G 124_F 1.105 0.96
157_K 174_Y 1.098 0.96
218_Q 222_K 1.092 0.96
27_L 119_L 1.084 0.96
100_E 108_R 1.075 0.95
9_L 13_L 1.067 0.95
86_R 91_G 1.066 0.95
51_V 129_I 1.063 0.95
45_D 117_E 1.06 0.95
69_S 72_R 1.056 0.95
41_E 117_E 1.054 0.95
48_L 120_I 1.052 0.95
39_R 57_Y 1.047 0.94
46_S 50_Y 1.044 0.94
131_T 135_L 1.041 0.94
105_G 108_R 1.041 0.94
47_I 121_G 1.035 0.94
58_H 137_L 1.034 0.94
200_P 219_A 1.033 0.94
20_Q 24_Q 1.03 0.94
110_S 114_D 1.025 0.93
37_N 118_A 1.024 0.93
17_F 127_S 1.006 0.93
63_V 71_M 1.005 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1o0wA20.99561000.162Contact Map0.821
3n3wA20.98671000.167Contact Map0.77
2a11A10.98231000.185Contact Map0.694
2nugA20.95581000.186Contact Map0.731
3rv0A40.97351000.23Contact Map0.733
3c4bA10.95131000.242Contact Map0.661
3o2rA20.64161000.428Contact Map0.76
2qvwA40.63721000.44Contact Map0.459
3rv1A20.66371000.467Contact Map0.668
1u61A10.53541000.596Contact Map0.574

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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