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OPENSEQ.org

RIBB - 3,4-dihydroxy-2-butanone 4-phosphate synthase
UniProt: P0A7J0 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10465
Length: 217 (203)
Sequences: 1746
Seq/Len: 8.60

RIBB
Paralog alert: 0.14 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
22_A 27_R 3.78 1.00
74_R 77_Q 3.669 1.00
59_I 66_V 3.338 1.00
151_G 206_V 3.148 1.00
177_N 187_E 2.998 1.00
157_T 170_G 2.971 1.00
124_D 167_K 2.466 1.00
48_E 167_K 2.426 1.00
18_N 198_A 2.397 1.00
21_A 25_E 2.393 1.00
76_K 141_R 2.303 1.00
59_I 176_T 2.174 1.00
14_E 18_N 2.168 1.00
22_A 198_A 2.157 1.00
19_A 200_V 2.142 1.00
126_A 131_L 2.141 1.00
68_L 121_A 2.123 1.00
45_F 54_Q 2.114 1.00
116_T 120_A 2.113 1.00
65_I 109_V 2.07 1.00
177_N 181_T 1.98 1.00
72_E 144_A 1.966 1.00
99_I 121_A 1.951 1.00
75_R 141_R 1.889 1.00
47_A 169_A 1.861 1.00
31_V 156_A 1.861 1.00
29_V 160_L 1.842 1.00
72_E 76_K 1.838 1.00
21_A 24_R 1.831 1.00
118_V 137_V 1.805 1.00
46_P 166_F 1.772 1.00
72_E 141_R 1.725 1.00
49_T 166_F 1.717 1.00
70_I 75_R 1.689 1.00
191_F 195_H 1.685 1.00
101_A 120_A 1.68 1.00
43_M 191_F 1.677 1.00
189_I 199_L 1.672 1.00
189_I 193_N 1.669 1.00
120_A 131_L 1.656 1.00
55_M 118_V 1.633 1.00
43_M 62_G 1.589 1.00
82_M 141_R 1.574 1.00
55_M 66_V 1.572 1.00
30_M 192_A 1.538 1.00
32_L 185_A 1.498 1.00
142_A 158_I 1.493 1.00
15_R 18_N 1.477 1.00
143_Q 149_T 1.462 0.99
120_A 123_A 1.443 0.99
75_R 80_L 1.441 0.99
51_T 54_Q 1.408 0.99
23_L 46_P 1.379 0.99
28_G 45_F 1.362 0.99
32_L 201_T 1.356 0.99
116_T 119_R 1.347 0.99
61_H 194_K 1.333 0.99
190_E 193_N 1.327 0.99
73_D 144_A 1.318 0.99
44_I 172_L 1.31 0.99
175_L 183_A 1.298 0.99
68_L 99_I 1.295 0.98
98_T 138_F 1.263 0.98
209_R 213_E 1.252 0.98
20_L 163_L 1.247 0.98
41_G 188_C 1.242 0.98
157_T 172_L 1.236 0.98
23_L 29_V 1.234 0.98
65_I 138_F 1.216 0.97
50_M 55_M 1.209 0.97
185_A 199_L 1.201 0.97
145_G 149_T 1.193 0.97
60_R 63_S 1.192 0.97
48_E 166_F 1.182 0.97
57_L 195_H 1.169 0.97
101_A 105_V 1.162 0.96
60_R 178_D 1.154 0.96
50_M 115_I 1.152 0.96
175_L 188_C 1.149 0.96
43_M 175_L 1.143 0.96
185_A 189_I 1.142 0.96
118_V 171_V 1.136 0.96
159_D 209_R 1.129 0.96
28_G 54_Q 1.115 0.95
52_V 115_I 1.112 0.95
44_I 153_H 1.11 0.95
187_E 190_E 1.086 0.94
71_T 168_P 1.08 0.94
30_M 197_M 1.074 0.94
177_N 183_A 1.07 0.94
13_F 201_T 1.063 0.93
56_A 63_S 1.048 0.93
163_L 205_L 1.044 0.92
23_L 161_M 1.041 0.92
104_G 113_D 1.04 0.92
102_A 132_N 1.039 0.92
65_I 98_T 1.027 0.92
192_A 199_L 1.023 0.91
160_L 200_V 1.02 0.91
161_M 169_A 1.019 0.91
79_D 133_R 1.01 0.91
28_G 43_M 1.007 0.91
31_V 200_V 1.003 0.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1g57A211000.045Contact Map0.832
1k4iA10.99541000.07Contact Map0.831
3mioA20.94011000.072Contact Map0.82
1tksA20.93551000.075Contact Map0.893
4ffjA10.94931000.082Contact Map0.803
4i14A20.95851000.087Contact Map0.834
1snnA20.93551000.087Contact Map0.831
4gimA30.866445.30.955Contact Map0.301
4gdvA20.5339.20.956Contact Map0.212
1y0nA10.248825.80.96Contact Map0.694

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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