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OPENSEQ.org
RIBA - GTP cyclohydrolase-2
UniProt: P0A7I7 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11331
Length: 196 (194)
Sequences: 1905
Seq/Len: 9.82
RIBA
Paralog alert: 0.21 [within 20: 0.02] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
23_F 139_L 4.63 1.00
8_E 19_L 3.526 1.00
144_E 164_N 3.386 1.00
53_E 90_R 3.172 1.00
112_Y 120_Q 2.879 1.00
10_K 17_D 2.859 1.00
78_I 86_L 2.772 1.00
5_R 21_V 2.769 1.00
37_Y 79_A 2.76 1.00
116_E 189_K 2.722 1.00
146_R 167_E 2.663 1.00
75_L 86_L 2.425 1.00
5_R 139_L 2.27 1.00
180_E 184_D 2.212 1.00
119_H 125_A 2.201 1.00
25_E 28_T 2.167 1.00
153_K 190_M 2.163 1.00
100_N 123_F 2.047 1.00
85_I 142_V 2.044 1.00
22_G 99_L 1.942 1.00
10_K 19_L 1.909 1.00
142_V 145_V 1.888 1.00
8_E 21_V 1.862 1.00
4_K 26_L 1.815 1.00
21_V 36_V 1.762 1.00
184_D 188_E 1.756 1.00
76_T 80_E 1.74 1.00
45_P 166_V 1.715 1.00
9_A 20_M 1.685 1.00
4_K 24_E 1.669 1.00
146_R 169_V 1.654 1.00
13_T 18_F 1.629 1.00
124_A 127_E 1.625 1.00
45_P 144_E 1.601 1.00
81_E 146_R 1.591 1.00
73_A 76_T 1.574 1.00
145_V 163_I 1.566 1.00
115_V 190_M 1.557 1.00
144_E 166_V 1.488 1.00
36_V 85_I 1.461 1.00
159_T 164_N 1.443 1.00
184_D 187_A 1.429 1.00
77_Q 148_L 1.424 1.00
106_A 110_Q 1.412 0.99
87_L 136_M 1.403 0.99
43_H 83_R 1.399 0.99
47_L 169_V 1.398 0.99
14_P 72_E 1.391 0.99
123_F 127_E 1.389 0.99
7_A 102_I 1.352 0.99
77_Q 81_E 1.345 0.99
156_E 160_E 1.335 0.99
5_R 8_E 1.326 0.99
47_L 77_Q 1.283 0.99
55_L 60_L 1.265 0.99
34_A 85_I 1.259 0.99
34_A 140_L 1.254 0.99
6_V 24_E 1.247 0.98
47_L 81_E 1.221 0.98
149_T 155_V 1.217 0.98
45_P 167_E 1.215 0.98
153_K 157_I 1.193 0.98
131_T 160_E 1.186 0.98
14_P 69_F 1.17 0.97
42_G 83_R 1.17 0.97
35_L 86_L 1.165 0.97
40_I 83_R 1.161 0.97
13_T 16_G 1.16 0.97
7_A 106_A 1.156 0.97
46_V 83_R 1.155 0.97
44_T 83_R 1.153 0.97
172_I 175_R 1.152 0.97
59_A 109_D 1.151 0.97
131_T 135_D 1.15 0.97
133_C 163_I 1.144 0.97
135_D 161_A 1.13 0.97
96_I 118_N 1.127 0.97
63_L 178_N 1.12 0.96
32_H 90_R 1.109 0.96
168_R 193_L 1.089 0.96
175_R 180_E 1.089 0.96
77_Q 80_E 1.087 0.95
156_E 159_T 1.083 0.95
77_Q 169_V 1.066 0.95
47_L 146_R 1.062 0.95
22_G 33_V 1.059 0.95
5_R 23_F 1.048 0.94
134_A 157_I 1.041 0.94
177_P 180_E 1.003 0.92
9_A 102_I 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2bz1A11100-0.015Contact Map0.794
4i14A21100-0.003Contact Map0.871
3ur8A20.408223.70.953Contact Map0.324
1aq0A20.413323.10.953Contact Map0.288
1ghsA20.39821.50.954Contact Map0.352
3em5A40.403114.90.957Contact Map0.342
2cygA10.413311.90.959Contact Map0.352
4e0aA20.739810.40.96Contact Map0.255
1vr9A20.85719.60.961Contact Map0.411
3q87A10.21947.80.962Contact Map0.025
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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