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OPENSEQ.org
RECO - DNA repair protein RecO
UniProt: P0A7H3 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10832
Length: 242 (229)
Sequences: 1331
Seq/Len: 5.81
RECO
Paralog alert: 0.00 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
7_A 24_V 3.269 1.00
24_V 34_L 3.202 1.00
154_S 174_A 3.15 1.00
31_R 97_S 3.031 1.00
24_V 58_L 2.921 1.00
7_A 58_L 2.911 1.00
91_Y 135_E 2.834 1.00
187_Q 204_A 2.678 1.00
27_E 111_F 2.428 1.00
151_C 154_S 2.234 1.00
6_R 27_E 2.209 1.00
132_R 135_E 2.162 1.00
8_F 114_L 2.14 1.00
7_A 26_T 2.099 1.00
35_V 66_V 2.084 1.00
92_I 116_C 2.03 1.00
26_T 30_G 1.966 1.00
5_Q 28_E 1.946 1.00
10_L 52_P 1.854 1.00
95_L 135_E 1.848 1.00
23_D 31_R 1.774 1.00
116_C 130_A 1.742 1.00
34_L 60_F 1.742 1.00
34_L 69_L 1.73 1.00
184_T 187_Q 1.687 1.00
37_K 68_T 1.686 1.00
151_C 174_A 1.632 1.00
126_T 202_L 1.62 0.99
55_P 110_F 1.603 0.99
33_R 66_V 1.563 0.99
15_W 35_V 1.543 0.99
91_Y 132_R 1.542 0.99
20_L 39_A 1.518 0.99
78_A 114_L 1.485 0.99
31_R 100_L 1.48 0.99
184_T 204_A 1.456 0.99
76_S 118_Q 1.451 0.99
92_I 113_Y 1.435 0.98
25_F 106_F 1.43 0.98
21_M 66_V 1.424 0.98
109_L 134_F 1.395 0.98
49_A 72_A 1.386 0.98
96_L 113_Y 1.375 0.98
135_E 139_L 1.368 0.98
5_Q 29_S 1.363 0.98
199_A 203_R 1.357 0.98
21_M 33_R 1.355 0.98
88_S 131_L 1.342 0.97
16_S 19_S 1.335 0.97
12_S 20_L 1.31 0.97
183_F 187_Q 1.306 0.97
96_L 100_L 1.301 0.97
25_F 96_L 1.298 0.97
59_R 71_S 1.294 0.96
135_E 206_K 1.291 0.96
136_L 209_T 1.29 0.96
128_E 206_K 1.285 0.96
51_Q 54_T 1.278 0.96
106_F 141_H 1.277 0.96
96_L 134_F 1.274 0.96
27_E 107_S 1.263 0.96
91_Y 210_R 1.258 0.96
99_V 142_L 1.248 0.95
8_F 113_Y 1.244 0.95
12_S 22_L 1.241 0.95
156_E 176_V 1.22 0.95
132_R 213_L 1.2 0.94
108_E 141_H 1.195 0.94
14_P 20_L 1.192 0.94
18_T 40_R 1.19 0.94
14_P 40_R 1.188 0.94
13_R 21_M 1.186 0.94
38_G 41_S 1.18 0.93
16_S 35_V 1.172 0.93
74_A 77_L 1.159 0.92
25_F 100_L 1.154 0.92
91_Y 228_F 1.152 0.92
204_A 211_M 1.148 0.92
147_N 150_H 1.144 0.92
186_R 201_T 1.14 0.92
166_Y 212_A 1.139 0.92
15_W 21_M 1.138 0.92
11_H 23_D 1.136 0.91
36_A 50_L 1.135 0.91
18_T 38_G 1.128 0.91
136_L 191_L 1.113 0.90
25_F 109_L 1.107 0.90
38_G 44_S 1.095 0.89
50_L 56_L 1.094 0.89
89_G 93_N 1.087 0.89
135_E 210_R 1.081 0.89
62_G 67_K 1.081 0.89
36_A 69_L 1.071 0.88
38_G 42_K 1.069 0.88
100_L 109_L 1.061 0.87
183_F 205_A 1.061 0.87
117_I 224_S 1.042 0.86
131_L 135_E 1.04 0.86
99_V 208_F 1.034 0.85
55_P 78_A 1.034 0.85
46_L 49_A 1.032 0.85
53_F 86_L 1.032 0.85
114_L 118_Q 1.031 0.85
179_D 182_T 1.027 0.85
14_P 21_M 1.026 0.85
61_G 70_R 1.024 0.85
91_Y 131_L 1.023 0.85
187_Q 205_A 1.021 0.84
19_S 38_G 1.012 0.84
22_L 52_P 1.002 0.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3q8dA20.99591000.127Contact Map0.792
1u5kA20.93391000.241Contact Map0.66
2owaA20.487649.10.938Contact Map0.579
3subA20.450447.70.939Contact Map0.692
2olmA10.462839.30.942Contact Map0.678
1dcqA10.4298380.942Contact Map0.732
2iqjA20.454537.30.943Contact Map0.646
3lvqE10.454526.90.947Contact Map0.735
1pftA10.18625.80.947Contact Map0.886
1dl6A10.21923.80.948Contact Map0.828
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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