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OPENSEQ.org
RECA - Protein RecA
UniProt: P0A7G6 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10823
Length: 353 (327)
Sequences: 1156
Seq/Len: 3.54
RECA
Paralog alert: 0.03 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
111_D 114_N 6.235 1.00
57_L 80_V 4.236 1.00
267_E 311_K 3.894 1.00
224_L 245_V 3.689 1.00
308_A 312_D 3.397 1.00
198_M 214_N 3.161 1.00
80_V 141_V 3.135 1.00
54_A 252_I 3.102 1.00
231_A 238_V 2.891 1.00
131_D 182_N 2.835 1.00
319_E 323_K 2.807 1.00
264_L 307_T 2.753 1.00
284_L 320_I 2.725 1.00
45_S 274_E 2.702 1.00
224_L 247_V 2.653 1.00
279_G 324_V 2.644 1.00
40_T 54_A 2.596 1.00
245_V 261_F 2.452 1.00
84_A 141_V 2.348 1.00
43_T 57_L 2.335 1.00
295_K 323_K 2.308 1.00
47_S 274_E 2.284 1.00
272_Y 311_K 2.234 1.00
275_L 317_A 2.213 1.00
294_Y 319_E 2.206 1.00
309_W 316_T 2.184 1.00
57_L 189_L 2.179 1.00
94_I 130_C 2.164 1.00
41_I 84_A 2.115 1.00
91_C 141_V 2.098 1.00
196_I 225_D 2.032 1.00
122_T 156_I 2.013 1.00
43_T 80_V 1.989 1.00
322_K 326_E 1.936 1.00
41_I 189_L 1.924 1.00
42_S 87_E 1.907 1.00
107_K 267_E 1.902 1.00
183_L 190_L 1.898 1.00
121_D 125_Q 1.895 1.00
244_R 258_Q 1.89 1.00
19_E 24_K 1.884 1.00
63_V 189_L 1.875 1.00
229_I 244_R 1.824 0.99
295_K 319_E 1.788 0.99
164_H 174_Q 1.745 0.99
17_Q 21_Q 1.738 0.99
309_W 313_N 1.724 0.99
276_V 303_K 1.692 0.99
52_L 222_V 1.684 0.99
280_V 292_Y 1.672 0.99
81_I 93_F 1.643 0.98
171_M 176_M 1.622 0.98
161_G 174_Q 1.579 0.98
79_Q 83_A 1.557 0.98
165_M 200_I 1.555 0.98
81_I 91_C 1.538 0.97
76_L 226_I 1.526 0.97
200_I 209_T 1.518 0.97
286_E 296_G 1.512 0.97
10_A 14_A 1.497 0.97
279_G 317_A 1.491 0.97
40_T 252_I 1.49 0.97
293_S 298_K 1.486 0.97
230_G 242_E 1.48 0.97
228_R 241_S 1.477 0.96
321_E 325_R 1.473 0.96
282_E 327_L 1.462 0.96
242_E 262_Q 1.459 0.96
234_E 304_A 1.455 0.96
38_V 252_I 1.425 0.95
270_N 307_T 1.403 0.95
154_A 167_L 1.402 0.95
59_M 89_K 1.39 0.95
30_L 112_I 1.389 0.95
276_V 279_G 1.382 0.94
29_R 114_N 1.382 0.94
153_K 157_E 1.369 0.94
47_S 278_L 1.363 0.94
130_C 144_V 1.34 0.93
200_I 214_N 1.33 0.93
225_D 229_I 1.326 0.93
243_T 265_Y 1.324 0.93
323_K 326_E 1.314 0.92
310_L 320_I 1.302 0.92
276_V 285_I 1.293 0.91
137_G 266_G 1.282 0.91
164_H 167_L 1.281 0.91
77_T 193_I 1.279 0.91
304_A 307_T 1.278 0.91
242_E 260_E 1.275 0.91
318_K 321_E 1.274 0.90
83_A 271_F 1.259 0.90
14_A 18_I 1.257 0.90
11_L 15_L 1.241 0.89
316_T 320_I 1.236 0.89
141_V 189_L 1.235 0.89
308_A 311_K 1.232 0.88
229_I 242_E 1.231 0.88
18_I 26_S 1.229 0.88
282_E 324_V 1.214 0.87
78_L 100_L 1.213 0.87
271_F 321_E 1.199 0.87
77_T 81_I 1.194 0.86
68_P 227_R 1.189 0.86
48_L 224_L 1.187 0.86
282_E 328_L 1.182 0.86
81_I 143_V 1.163 0.84
318_K 322_K 1.158 0.84
46_L 50_I 1.153 0.84
228_R 231_A 1.149 0.83
299_I 316_T 1.142 0.83
62_I 180_A 1.14 0.83
83_A 87_E 1.137 0.82
22_F 196_I 1.13 0.82
68_P 225_D 1.121 0.81
202_V 206_N 1.118 0.81
48_L 247_V 1.112 0.80
277_D 303_K 1.104 0.80
313_N 316_T 1.1 0.79
317_A 321_E 1.094 0.79
303_K 307_T 1.088 0.78
274_E 279_G 1.08 0.78
93_F 98_H 1.079 0.78
292_Y 297_E 1.074 0.77
315_E 318_K 1.073 0.77
18_I 27_I 1.066 0.76
184_K 187_N 1.065 0.76
33_D 36_M 1.063 0.76
130_C 134_A 1.062 0.76
27_I 116_L 1.05 0.75
19_E 27_I 1.047 0.75
242_E 303_K 1.045 0.74
163_S 167_L 1.04 0.74
39_E 87_E 1.036 0.73
92_A 133_L 1.035 0.73
296_G 299_I 1.035 0.73
267_E 270_N 1.034 0.73
93_F 100_L 1.034 0.73
5_E 8_Q 1.03 0.73
196_I 286_E 1.028 0.73
160_I 171_M 1.021 0.72
50_I 328_L 1.018 0.72
130_C 142_I 1 0.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3cmwA20.9491000.419Contact Map0.729
1u94A111000.464Contact Map0.731
3cmuA10.9491000.475Contact Map0.685
3hr8A10.98021000.49Contact Map0.672
2zr9A10.98581000.493Contact Map0.689
1xp8A10.98871000.534Contact Map0.681
3io5A20.86121000.552Contact Map0.354
3ldaA10.73091000.769Contact Map0.563
1pznA70.72241000.776Contact Map0.548
1v5wA20.71951000.777Contact Map0.497
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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