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OPENSEQ.org

PUR7 - Phosphoribosylaminoimidazole-succinocarboxamide synthase
UniProt: P0A7D7 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10791
Length: 237 (234)
Sequences: 1695
Seq/Len: 7.24

PUR7
Paralog alert: 0.04 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
92_V 121_F 4.356 1.00
167_D 203_K 3.382 1.00
145_K 149_A 3.381 1.00
36_D 128_H 2.991 1.00
93_V 155_T 2.953 1.00
86_M 190_G 2.914 1.00
5_A 17_S 2.603 1.00
134_E 152_K 2.593 1.00
84_L 190_G 2.549 1.00
60_K 161_V 2.542 1.00
150_R 153_E 2.513 1.00
67_P 186_E 2.466 1.00
164_K 168_D 2.333 1.00
182_L 186_E 2.237 1.00
23_L 71_E 2.158 1.00
87_V 187_V 2.124 1.00
62_A 68_T 2.021 1.00
60_K 165_L 1.983 1.00
172_I 206_L 1.916 1.00
75_S 78_E 1.913 1.00
108_E 111_I 1.904 1.00
170_G 204_E 1.889 1.00
96_R 112_E 1.796 1.00
153_E 157_K 1.781 1.00
18_T 80_L 1.778 1.00
24_L 81_V 1.777 1.00
35_G 38_A 1.764 1.00
20_N 23_L 1.764 1.00
17_S 83_K 1.734 1.00
31_D 42_Q 1.707 1.00
57_I 166_F 1.685 1.00
59_S 62_A 1.674 1.00
96_R 174_V 1.673 1.00
45_R 48_M 1.671 1.00
63_E 161_V 1.611 1.00
150_R 154_L 1.594 1.00
93_V 156_Y 1.594 1.00
222_I 226_E 1.582 1.00
147_N 187_V 1.577 1.00
14_T 27_E 1.576 1.00
14_T 29_R 1.55 1.00
118_F 137_C 1.531 0.99
160_D 164_K 1.512 0.99
150_R 186_E 1.501 0.99
55_Y 73_L 1.499 0.99
112_E 167_D 1.491 0.99
98_A 109_E 1.482 0.99
149_A 153_E 1.478 0.99
95_N 159_N 1.478 0.99
54_N 58_M 1.454 0.99
55_Y 70_M 1.409 0.99
114_N 141_G 1.408 0.99
112_E 163_K 1.403 0.99
115_P 160_D 1.384 0.99
171_L 200_L 1.383 0.99
138_E 145_K 1.382 0.99
87_V 147_N 1.381 0.99
157_K 161_V 1.376 0.99
173_L 200_L 1.371 0.99
202_D 205_T 1.357 0.98
227_A 231_R 1.341 0.98
28_F 51_N 1.324 0.98
82_K 182_L 1.305 0.98
38_A 128_H 1.298 0.98
55_Y 79_C 1.292 0.98
220_G 223_E 1.289 0.98
226_E 230_R 1.283 0.98
58_M 79_C 1.268 0.97
134_E 149_A 1.265 0.97
56_F 60_K 1.255 0.97
97_A 102_V 1.254 0.97
96_R 172_I 1.249 0.97
97_A 111_I 1.249 0.97
32_T 214_F 1.245 0.97
121_F 131_M 1.242 0.97
70_M 79_C 1.239 0.97
165_L 168_D 1.23 0.97
107_I 111_I 1.224 0.97
64_A 164_K 1.221 0.97
171_L 228_V 1.201 0.96
154_L 187_V 1.195 0.96
120_L 137_C 1.191 0.96
178_L 197_G 1.187 0.96
166_F 200_L 1.178 0.95
158_A 178_L 1.168 0.95
102_V 107_I 1.168 0.95
101_L 113_L 1.165 0.95
144_S 147_N 1.165 0.95
91_C 151_M 1.159 0.95
72_R 80_L 1.159 0.95
49_V 53_F 1.157 0.95
165_L 232_L 1.154 0.95
9_R 14_T 1.152 0.95
39_R 214_F 1.143 0.94
41_E 214_F 1.137 0.94
87_V 151_M 1.136 0.94
6_E 14_T 1.129 0.94
52_K 76_D 1.129 0.94
48_M 77_T 1.115 0.93
91_C 155_T 1.102 0.93
154_L 157_K 1.085 0.92
154_L 158_A 1.084 0.92
211_K 215_R 1.082 0.92
71_E 82_K 1.078 0.92
35_G 219_G 1.07 0.91
220_G 224_A 1.07 0.91
134_E 148_L 1.068 0.91
164_K 167_D 1.067 0.91
92_V 151_M 1.059 0.91
15_V 26_L 1.057 0.91
143_V 151_M 1.056 0.91
9_R 29_R 1.053 0.91
60_K 64_A 1.051 0.90
48_M 76_D 1.048 0.90
59_S 70_M 1.047 0.90
59_S 63_E 1.037 0.90
158_A 189_L 1.036 0.90
107_I 113_L 1.031 0.89
56_F 165_L 1.031 0.89
30_N 44_D 1.013 0.88
132_V 136_Y 1 0.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3kreA111000.008Contact Map0.774
2gqrA211000.01Contact Map0.717
2z02A20.98731000.02Contact Map0.733
3nuaA20.98311000.02Contact Map0.759
2ywvA211000.024Contact Map0.709
4fe2A20.99161000.031Contact Map0.71
3u55A10.99161000.055Contact Map0.746
1kutA20.9621000.056Contact Map0.735
4ja0A411000.068Contact Map0.6
2h31A111000.069Contact Map0.617

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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