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OPENSEQ.org
PPNK - Probable inorganic polyphosphate/ATP-NAD kinase
UniProt: P0A7B3 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12192
Length: 292 (286)
Sequences: 1873
Seq/Len: 6.55
PPNK
Paralog alert: 0.07 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
125_K 268_N 3.713 1.00
13_H 16_H 3.094 1.00
228_T 261_R 3.028 1.00
191_S 209_V 2.96 1.00
76_M 269_L 2.925 1.00
33_K 114_A 2.9 1.00
162_F 231_L 2.781 1.00
135_Q 256_E 2.765 1.00
230_R 257_D 2.641 1.00
204_D 225_S 2.611 1.00
167_D 227_S 2.569 1.00
25_M 110_Q 2.549 1.00
232_R 257_D 2.458 1.00
29_W 114_A 2.372 1.00
126_R 185_T 2.263 1.00
130_E 261_R 2.224 1.00
7_C 36_E 2.187 1.00
19_A 23_H 2.183 1.00
230_R 259_L 2.174 1.00
115_D 120_H 2.151 1.00
125_K 266_H 2.132 1.00
108_N 111_Q 2.092 1.00
168_E 230_R 2.036 1.00
129_L 206_I 2.017 1.00
163_E 232_R 1.971 1.00
26_L 113_L 1.939 1.00
164_V 208_L 1.926 1.00
199_L 207_T 1.876 1.00
149_V 242_I 1.874 1.00
165_Y 170_F 1.869 1.00
131_A 149_V 1.866 1.00
208_L 223_I 1.858 1.00
81_R 247_Q 1.857 1.00
170_F 173_S 1.857 1.00
151_L 231_L 1.836 1.00
216_L 219_R 1.808 1.00
76_M 92_G 1.729 1.00
132_Q 261_R 1.688 1.00
181_I 231_L 1.673 1.00
132_Q 259_L 1.669 1.00
169_I 276_S 1.666 1.00
123_S 268_N 1.625 1.00
164_V 179_L 1.618 1.00
67_A 83_L 1.549 0.99
103_D 271_H 1.502 0.99
223_I 229_I 1.47 0.99
124_E 271_H 1.452 0.99
114_A 118_E 1.452 0.99
8_I 66_L 1.447 0.99
128_L 267_L 1.444 0.99
91_I 116_V 1.422 0.99
94_N 284_K 1.419 0.99
9_G 64_A 1.412 0.99
70_V 95_R 1.411 0.99
166_I 229_I 1.409 0.99
228_T 259_L 1.402 0.99
80_A 90_V 1.391 0.98
132_Q 142_I 1.385 0.98
168_E 228_T 1.369 0.98
149_V 260_I 1.368 0.98
148_E 180_I 1.332 0.98
148_E 247_Q 1.33 0.98
87_D 265_Y 1.317 0.98
200_T 278_F 1.313 0.98
100_F 278_F 1.312 0.98
194_A 212_F 1.311 0.98
122_I 274_D 1.311 0.98
165_Y 168_E 1.297 0.97
199_L 222_V 1.295 0.97
277_Y 281_L 1.277 0.97
12_G 23_H 1.274 0.97
20_L 23_H 1.251 0.96
11_V 79_A 1.243 0.96
181_I 208_L 1.239 0.96
29_W 33_K 1.237 0.96
21_T 28_R 1.236 0.96
197_P 222_V 1.235 0.96
91_I 270_I 1.212 0.96
130_E 142_I 1.21 0.95
201_P 277_Y 1.201 0.95
165_Y 232_R 1.2 0.95
98_L 214_H 1.178 0.95
80_A 267_L 1.17 0.94
194_A 209_V 1.17 0.94
206_I 229_I 1.169 0.94
28_R 32_T 1.144 0.93
131_A 258_V 1.133 0.93
157_A 243_S 1.133 0.93
131_A 244_C 1.132 0.93
66_L 116_V 1.132 0.93
192_L 216_L 1.129 0.93
286_G 289_K 1.125 0.93
145_A 244_C 1.123 0.93
26_L 70_V 1.123 0.93
166_I 223_I 1.119 0.92
150_V 180_I 1.108 0.92
7_C 38_I 1.092 0.91
93_I 109_A 1.089 0.91
128_L 263_C 1.088 0.91
166_I 227_S 1.086 0.91
68_V 113_L 1.077 0.90
165_Y 230_R 1.077 0.90
167_D 228_T 1.075 0.90
185_T 201_P 1.067 0.90
13_H 200_T 1.067 0.90
192_L 285_L 1.065 0.90
134_C 139_Q 1.062 0.89
136_Q 139_Q 1.061 0.89
97_N 175_R 1.058 0.89
153_P 157_A 1.048 0.89
76_M 102_T 1.047 0.89
27_Y 31_C 1.046 0.88
188_T 198_I 1.046 0.88
120_H 273_K 1.041 0.88
29_W 113_L 1.038 0.88
144_T 263_C 1.036 0.88
21_T 32_T 1.03 0.87
128_L 266_H 1.028 0.87
29_W 110_Q 1.023 0.87
7_C 63_L 1.022 0.87
205_A 222_V 1.017 0.87
205_A 221_L 1.015 0.86
220_P 287_W 1.013 0.86
207_T 277_Y 1.009 0.86
85_R 265_Y 1.008 0.86
70_V 93_I 1.004 0.86
50_K 54_T 1.003 0.86
180_I 210_P 1.001 0.85
136_Q 140_K 1.001 0.85
21_T 25_M 1 0.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3pfnA40.99661000.163Contact Map0.778
3afoA211000.195Contact Map0.688
2an1A411000.3Contact Map0.858
1u0tA20.98971000.336Contact Map0.729
1yt5A40.87331000.39Contact Map0.763
1z0sA40.86641000.399Contact Map0.829
2i2cA10.89041000.405Contact Map0.717
2qv7A10.93151000.656Contact Map0.416
3s40A40.86641000.675Contact Map0.499
2bonA20.893899.90.739Contact Map0.386
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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