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OPENSEQ.org
MNTH - Divalent metal cation transporter MntH
UniProt: P0A769 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14157
Length: 412 (398)
Sequences: 1859
Seq/Len: 4.67
MNTH
Paralog alert: 0.31 [within 20: 0.02] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
79_K 87_D 5.867 1.00
178_N 181_Q 3.931 1.00
372_S 387_K 3.162 1.00
384_K 388_Q 2.776 1.00
374_S 381_V 2.774 1.00
371_T 382_N 2.672 1.00
65_L 393_I 2.443 1.00
277_L 280_Q 2.353 1.00
76_A 380_L 2.326 1.00
382_N 387_K 2.224 1.00
88_H 373_D 2.217 1.00
384_K 387_K 2.126 1.00
368_L 390_G 2.083 1.00
365_V 398_V 1.989 1.00
92_P 96_F 1.982 1.00
99_V 103_I 1.966 1.00
95_W 99_V 1.92 1.00
372_S 382_N 1.865 1.00
274_E 277_L 1.844 1.00
68_I 72_K 1.83 1.00
179_L 182_L 1.82 1.00
119_G 296_V 1.802 1.00
403_W 407_G 1.782 1.00
186_M 251_L 1.778 1.00
307_T 311_Q 1.743 1.00
90_P 93_V 1.721 0.99
80_N 83_E 1.715 0.99
395_V 399_A 1.707 0.99
126_V 134_L 1.696 0.99
62_M 393_I 1.691 0.99
244_T 248_F 1.679 0.99
26_F 242_A 1.676 0.99
79_K 84_Q 1.673 0.99
72_K 382_N 1.661 0.99
218_S 312_V 1.652 0.99
84_Q 87_D 1.646 0.99
182_L 255_A 1.642 0.99
77_T 376_L 1.614 0.99
64_M 240_A 1.611 0.99
402_I 406_V 1.59 0.99
365_V 394_V 1.572 0.99
251_L 255_A 1.561 0.99
280_Q 285_H 1.559 0.99
120_F 124_L 1.537 0.99
69_L 382_N 1.52 0.98
212_V 305_V 1.517 0.98
327_R 331_T 1.515 0.98
68_I 236_K 1.515 0.98
161_L 301_S 1.5 0.98
224_H 227_S 1.495 0.98
365_V 369_I 1.49 0.98
132_A 339_I 1.471 0.98
280_Q 288_A 1.469 0.98
71_A 235_T 1.453 0.98
151_K 155_K 1.45 0.98
364_L 394_V 1.447 0.98
32_Y 246_A 1.441 0.98
162_L 166_A 1.43 0.97
373_D 376_L 1.428 0.97
40_T 202_G 1.402 0.97
43_Q 47_S 1.392 0.97
133_V 137_I 1.357 0.96
137_I 141_L 1.353 0.96
349_L 352_S 1.336 0.96
108_T 112_E 1.335 0.96
206_A 209_M 1.327 0.96
73_L 84_Q 1.323 0.95
39_A 275_A 1.322 0.95
133_V 336_F 1.318 0.95
181_Q 185_G 1.317 0.95
344_D 347_R 1.31 0.95
48_F 195_E 1.283 0.94
323_P 326_V 1.279 0.94
89_Y 369_I 1.278 0.94
175_S 259_A 1.276 0.94
369_I 373_D 1.271 0.94
171_E 256_T 1.271 0.94
73_L 371_T 1.267 0.94
180_A 184_K 1.262 0.94
65_L 386_V 1.259 0.94
368_L 372_S 1.257 0.94
66_I 364_L 1.257 0.94
37_N 41_N 1.253 0.93
354_V 367_L 1.245 0.93
198_F 351_M 1.235 0.93
27_I 305_V 1.233 0.93
38_F 294_S 1.233 0.93
245_I 249_V 1.222 0.92
121_K 273_D 1.221 0.92
170_V 174_F 1.216 0.92
225_G 379_D 1.215 0.92
111_A 352_S 1.214 0.92
183_G 187_V 1.211 0.92
47_S 195_E 1.205 0.92
126_V 131_G 1.203 0.91
25_A 119_G 1.197 0.91
48_F 193_T 1.196 0.91
369_I 391_W 1.194 0.91
173_I 177_P 1.188 0.91
32_Y 37_N 1.187 0.91
388_Q 392_V 1.184 0.91
326_V 329_T 1.184 0.91
67_Q 82_A 1.183 0.90
127_S 130_Q 1.181 0.90
399_A 402_I 1.179 0.90
398_V 402_I 1.172 0.90
396_L 399_A 1.167 0.90
212_V 216_H 1.165 0.90
34_D 37_N 1.162 0.89
135_T 296_V 1.154 0.89
122_L 174_F 1.154 0.89
388_Q 399_A 1.149 0.89
383_S 388_Q 1.146 0.89
386_V 390_G 1.146 0.89
179_L 183_G 1.146 0.89
111_A 349_L 1.145 0.88
269_V 274_E 1.144 0.88
31_G 38_F 1.142 0.88
50_Y 259_A 1.137 0.88
370_F 376_L 1.136 0.88
29_A 33_I 1.136 0.88
198_F 354_V 1.131 0.88
278_T 294_S 1.127 0.87
61_L 65_L 1.127 0.87
374_S 379_D 1.125 0.87
172_L 255_A 1.124 0.87
381_V 384_K 1.123 0.87
351_M 355_L 1.123 0.87
41_N 253_M 1.123 0.87
337_I 341_M 1.117 0.87
35_P 299_G 1.117 0.87
91_R 95_W 1.117 0.87
210_P 356_L 1.112 0.86
184_K 190_S 1.11 0.86
172_L 252_A 1.099 0.86
112_E 115_G 1.093 0.85
173_I 176_Q 1.092 0.85
336_F 340_L 1.09 0.85
181_Q 184_K 1.089 0.85
62_M 204_L 1.088 0.85
343_L 348_I 1.087 0.85
115_G 295_L 1.085 0.85
137_I 140_F 1.085 0.85
215_L 219_L 1.082 0.84
406_V 410_L 1.081 0.84
383_S 386_V 1.081 0.84
281_P 287_A 1.079 0.84
56_V 260_A 1.077 0.84
326_V 330_V 1.076 0.84
178_N 182_L 1.073 0.84
389_T 393_I 1.069 0.83
112_E 206_A 1.066 0.83
53_L 251_L 1.062 0.83
72_K 298_A 1.059 0.83
232_Y 236_K 1.059 0.83
388_Q 395_V 1.059 0.83
372_S 391_W 1.058 0.83
28_A 239_V 1.056 0.82
286_A 290_V 1.052 0.82
19_L 24_P 1.048 0.82
98_W 102_E 1.047 0.82
387_K 391_W 1.047 0.82
391_W 395_V 1.044 0.81
233_S 237_W 1.042 0.81
34_D 112_E 1.038 0.81
41_N 108_T 1.034 0.81
229_Q 374_S 1.03 0.80
28_A 213_I 1.027 0.80
209_M 250_N 1.027 0.80
30_I 34_D 1.026 0.80
37_N 250_N 1.025 0.80
107_A 352_S 1.024 0.80
168_Y 249_V 1.022 0.79
203_V 254_M 1.02 0.79
211_H 217_S 1.019 0.79
163_F 293_L 1.013 0.79
42_I 275_A 1.011 0.78
76_A 232_Y 1.01 0.78
102_E 109_D 1.01 0.78
41_N 201_A 1.008 0.78
210_P 213_I 1.007 0.78
44_A 199_L 1.004 0.78
41_N 250_N 1 0.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3dh4A40.956398.80.884Contact Map0.371
3l1lA10.936998.50.895Contact Map0.422
2xq2A10.956398.30.9Contact Map0.366
2jlnA10.953998.20.903Contact Map0.302
3giaA10.912697.80.912Contact Map0.386
4djkA20.936997.80.913Contact Map0.297
2a65A10.93274.90.955Contact Map0.369
4m48A10.915580.96Contact Map0.349
1mukA10.155327.70.967Contact Map0.007
3r12A20.162610.40.973Contact Map0.302
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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