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OPENSEQ.org

NDK - Nucleoside diphosphate kinase
UniProt: P0A763 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10650
Length: 143 (140)
Sequences: 1908
Seq/Len: 13.63

NDK
Paralog alert: 0.04 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
44_V 48_R 3.746 1.00
22_N 29_A 2.851 1.00
37_T 73_V 2.738 1.00
94_N 97_N 2.672 1.00
76_V 129_I 2.668 1.00
9_I 74_V 2.448 1.00
121_S 124_S 2.401 1.00
26_R 106_D 2.302 1.00
42_L 132_F 2.267 1.00
90_L 118_G 2.219 1.00
10_I 14_A 2.176 1.00
88_D 99_L 2.156 1.00
83_V 122_V 2.137 1.00
27_F 86_H 2.107 1.00
34_I 77_L 2.054 1.00
25_A 29_A 2.029 1.00
47_A 67_M 1.998 1.00
44_V 65_E 1.992 1.00
24_F 75_S 1.918 1.00
49_G 131_Y 1.903 1.00
81_N 84_Q 1.866 1.00
43_T 46_Q 1.838 1.00
8_S 86_H 1.831 1.00
53_E 127_R 1.826 1.00
4_E 122_V 1.783 1.00
32_F 85_R 1.778 1.00
49_G 52_A 1.737 1.00
32_F 82_A 1.734 1.00
90_L 116_T 1.726 1.00
32_F 79_G 1.66 1.00
79_G 85_R 1.651 1.00
134_G 137_E 1.624 1.00
100_A 105_A 1.565 1.00
20_I 73_V 1.555 1.00
22_N 25_A 1.55 1.00
120_D 124_S 1.497 1.00
124_S 127_R 1.487 1.00
56_G 61_D 1.467 1.00
80_E 110_S 1.466 1.00
24_F 37_T 1.449 1.00
46_Q 131_Y 1.445 1.00
81_N 85_R 1.444 1.00
5_R 78_E 1.385 0.99
40_L 74_V 1.382 0.99
61_D 65_E 1.375 0.99
30_A 89_L 1.352 0.99
86_H 118_G 1.338 0.99
64_V 68_T 1.337 0.99
47_A 68_T 1.33 0.99
48_R 55_D 1.325 0.99
84_Q 88_D 1.297 0.99
5_R 35_V 1.291 0.99
125_A 129_I 1.263 0.99
62_G 112_T 1.261 0.99
38_K 137_E 1.251 0.99
9_I 72_I 1.246 0.98
48_R 60_F 1.212 0.98
94_N 111_L 1.179 0.98
53_E 124_S 1.177 0.98
44_V 61_D 1.156 0.97
27_F 77_L 1.153 0.97
36_G 138_V 1.147 0.97
92_A 99_L 1.115 0.96
83_V 124_S 1.111 0.96
37_T 75_S 1.077 0.95
16_A 113_E 1.071 0.95
35_V 78_E 1.056 0.95
36_G 76_V 1.041 0.94
86_H 90_L 1.041 0.94
14_A 23_I 1.036 0.94
24_F 73_V 1.034 0.94
14_A 115_G 1.022 0.93
5_R 126_A 1.019 0.93
126_A 130_A 1.012 0.93
122_V 126_A 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4fkxA31100-0.012Contact Map0.754
1xiqA611000.001Contact Map0.853
1w7wA611000.002Contact Map0.713
2vu5A10.9861000.002Contact Map0.636
3r9lA111000.004Contact Map0.766
4c6aA111000.004Contact Map0.715
3b54A211000.004Contact Map0.678
3fkbA611000.005Contact Map0.758
3l7uA311000.006Contact Map0.745
3q8uA60.9861000.007Contact Map0.781

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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