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OPENSEQ.org
NANE - Putative N-acetylmannosamine-6-phosphate 2-epimerase
UniProt: P0A761 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12816
Length: 229 (218)
Sequences: 469
Seq/Len: 2.15
NANE
Paralog alert: 0.22 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
16_G 48_V 4.663 1.00
45_A 217_C 3.557 1.00
139_G 174_L 2.736 1.00
55_V 73_V 2.564 1.00
43_E 67_V 2.523 1.00
29_L 38_M 2.405 1.00
193_A 204_V 2.317 1.00
134_S 138_D 2.22 1.00
92_D 125_H 2.212 1.00
62_R 69_I 2.082 0.99
114_P 117_T 2.034 0.99
208_S 215_H 2 0.99
62_R 100_D 1.995 0.99
75_R 93_A 1.975 0.99
50_I 61_T 1.971 0.99
36_A 60_A 1.881 0.99
194_A 198_R 1.872 0.98
136_P 173_T 1.78 0.98
97_A 100_D 1.742 0.97
113_V 121_R 1.689 0.97
150_I 179_C 1.685 0.96
35_V 61_T 1.684 0.96
195_D 199_H 1.68 0.96
52_I 61_T 1.659 0.96
119_L 129_A 1.651 0.96
94_L 102_I 1.646 0.96
195_D 198_R 1.638 0.96
19_V 217_C 1.621 0.95
119_L 147_A 1.617 0.95
32_P 36_A 1.581 0.94
215_H 219_W 1.565 0.94
130_M 151_G 1.563 0.94
168_L 195_D 1.555 0.94
106_G 142_C 1.543 0.93
155_S 167_D 1.534 0.93
209_A 220_Y 1.531 0.93
168_L 199_H 1.515 0.93
113_V 118_L 1.499 0.92
136_P 170_L 1.487 0.92
95_A 99_A 1.486 0.92
134_S 160_P 1.462 0.91
171_V 201_A 1.449 0.90
105_D 109_R 1.425 0.89
89_E 93_A 1.404 0.88
136_P 140_L 1.373 0.87
81_P 159_T 1.369 0.87
129_A 147_A 1.354 0.86
189_T 220_Y 1.35 0.85
165_E 186_R 1.349 0.85
141_A 144_K 1.335 0.85
35_V 57_N 1.329 0.84
116_E 141_A 1.329 0.84
210_I 213_L 1.315 0.83
169_A 173_T 1.289 0.82
83_R 154_L 1.283 0.81
120_A 124_H 1.275 0.81
135_T 161_E 1.273 0.81
188_N 192_Q 1.268 0.80
193_A 197_M 1.246 0.79
149_I 202_W 1.243 0.78
123_H 129_A 1.239 0.78
19_V 135_T 1.227 0.77
155_S 166_P 1.226 0.77
133_C 138_D 1.223 0.77
77_L 90_D 1.222 0.77
190_P 206_V 1.219 0.76
155_S 170_L 1.217 0.76
123_H 147_A 1.214 0.76
196_A 204_V 1.211 0.76
11_I 14_N 1.201 0.75
149_I 182_I 1.199 0.75
218_Q 222_T 1.197 0.75
81_P 109_R 1.194 0.74
35_V 52_I 1.183 0.73
182_I 203_A 1.178 0.73
58_L 94_L 1.167 0.72
197_M 224_M 1.165 0.72
43_E 66_S 1.157 0.71
140_L 144_K 1.149 0.70
123_H 126_G 1.145 0.70
40_L 44_Q 1.142 0.70
121_R 124_H 1.133 0.69
201_A 204_V 1.124 0.68
33_E 36_A 1.123 0.68
135_T 138_D 1.121 0.67
17_L 206_V 1.117 0.67
166_P 170_L 1.115 0.67
13_A 101_I 1.102 0.66
108_D 141_A 1.1 0.65
171_V 187_Y 1.083 0.64
83_R 86_A 1.074 0.63
42_A 67_V 1.072 0.62
24_V 212_R 1.065 0.62
133_C 139_G 1.063 0.61
73_V 94_L 1.063 0.61
27_S 35_V 1.06 0.61
45_A 221_N 1.059 0.61
67_V 138_D 1.058 0.61
40_L 59_Q 1.056 0.61
213_L 217_C 1.053 0.60
115_V 147_A 1.049 0.60
80_S 112_P 1.048 0.60
108_D 160_P 1.035 0.58
75_R 90_D 1.027 0.57
188_N 219_W 1.023 0.57
175_S 181_V 1.014 0.56
24_V 35_V 1.008 0.55
24_V 27_S 1.003 0.55
23_P 27_S 1.001 0.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1yxyA20.98691000.65Contact Map0.665
3q58A20.98691000.652Contact Map0.706
1y0eA20.94321000.654Contact Map0.779
3igsA211000.654Contact Map0.718
2p10A60.94761000.674Contact Map0.554
4mozA50.96071000.684Contact Map0.406
1ub3A40.873499.90.733Contact Map0.469
1jvnA20.969499.90.734Contact Map0.474
1n7kA20.899699.90.735Contact Map0.432
3ndoA20.899699.90.74Contact Map0.418
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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