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OPENSEQ.org
NADD - Nicotinate-nucleotide adenylyltransferase
UniProt: P0A752 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13241
Length: 213 (210)
Sequences: 1974
Seq/Len: 9.40
NADD
Paralog alert: 0.03 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
74_E 78_K 4.49 1.00
34_R 71_T 4.147 1.00
37_I 70_F 3.451 1.00
119_E 122_T 3.109 1.00
15_V 60_L 2.921 1.00
30_I 130_I 2.839 1.00
13_D 51_A 2.838 1.00
27_A 69_L 2.773 1.00
58_H 61_E 2.663 1.00
6_A 32_L 2.607 1.00
55_Q 205_Y 2.586 1.00
55_Q 209_Q 2.526 1.00
114_F 123_I 2.488 1.00
194_C 198_L 2.411 1.00
89_L 123_I 2.363 1.00
59_M 205_Y 2.328 1.00
123_I 129_L 2.311 1.00
89_L 127_A 2.216 1.00
186_E 190_N 2.215 1.00
36_T 73_D 2.146 1.00
90_K 122_T 2.089 1.00
64_I 72_L 2.062 1.00
55_Q 58_H 2.038 1.00
62_L 205_Y 2.014 1.00
79_R 87_Q 2.012 1.00
57_K 74_E 1.907 1.00
23_V 37_I 1.869 1.00
60_L 72_L 1.86 1.00
36_T 102_L 1.844 1.00
104_F 129_L 1.841 1.00
90_K 119_E 1.835 1.00
188_L 194_C 1.811 1.00
67_K 196_D 1.783 1.00
52_N 55_Q 1.748 1.00
75_R 91_E 1.742 1.00
86_A 90_K 1.724 1.00
93_R 126_N 1.717 1.00
183_I 187_R 1.71 1.00
13_D 50_E 1.708 1.00
24_E 67_K 1.652 1.00
26_L 105_I 1.598 1.00
200_E 203_L 1.589 1.00
15_V 63_A 1.586 1.00
203_L 207_N 1.585 1.00
57_K 72_L 1.542 1.00
62_L 201_P 1.462 1.00
5_Q 100_V 1.419 0.99
194_C 203_L 1.416 0.99
65_A 201_P 1.401 0.99
86_A 119_E 1.39 0.99
183_I 186_E 1.337 0.99
13_D 49_P 1.337 0.99
45_H 116_T 1.32 0.99
60_L 64_I 1.314 0.99
53_S 77_L 1.291 0.99
11_T 43_P 1.288 0.99
6_A 105_I 1.274 0.99
103_A 130_I 1.265 0.98
15_V 59_M 1.263 0.98
205_Y 211_L 1.258 0.98
86_A 126_N 1.239 0.98
44_P 83_S 1.225 0.98
101_P 128_H 1.224 0.98
21_K 177_F 1.191 0.98
75_R 95_E 1.174 0.97
79_R 91_E 1.166 0.97
195_E 200_E 1.158 0.97
41_N 77_L 1.157 0.97
204_T 208_Q 1.155 0.97
36_T 71_T 1.154 0.97
85_T 104_F 1.148 0.97
24_E 27_A 1.143 0.97
57_K 61_E 1.133 0.96
10_G 16_H 1.133 0.96
51_A 211_L 1.131 0.96
26_L 172_A 1.126 0.96
37_I 64_I 1.126 0.96
128_H 170_Y 1.124 0.96
111_L 131_V 1.118 0.96
124_L 129_L 1.092 0.95
20_L 199_P 1.089 0.95
206_I 211_L 1.075 0.95
187_R 192_E 1.074 0.95
8_F 22_P 1.063 0.94
23_V 70_F 1.062 0.94
133_R 173_E 1.06 0.94
51_A 55_Q 1.057 0.94
195_E 203_L 1.056 0.94
184_I 198_L 1.049 0.94
46_R 181_A 1.042 0.93
89_L 126_N 1.039 0.93
41_N 80_N 1.029 0.93
17_Y 199_P 1.024 0.93
205_Y 209_Q 1.022 0.93
58_H 62_L 1.013 0.92
135_P 176_W 1.008 0.92
59_M 206_I 1.005 0.92
75_R 92_W 1.004 0.92
75_R 79_R 1.003 0.92
210_G 213_R 1.003 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1k4mA30.99531000.2Contact Map0.879
1yumA40.99061000.233Contact Map0.83
1kqnA60.92961000.243Contact Map0.764
1nupA20.92961000.284Contact Map0.764
1kamA40.88261000.294Contact Map0.855
2qtrA30.87791000.294Contact Map0.891
2h29A20.87791000.305Contact Map0.796
3h05A20.77931000.391Contact Map0.751
1v47A20.84511000.463Contact Map0.528
1o6bA10.75121000.487Contact Map0.695
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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