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OPENSEQ.org
MSRA - Peptide methionine sulfoxide reductase MsrA
UniProt: P0A744 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11433
Length: 212 (205)
Sequences: 869
Seq/Len: 4.24
MSRA
Paralog alert: 0.03 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
46_A 108_Y 5.028 1.00
147_D 151_R 3.413 1.00
70_A 180_F 3.301 1.00
116_W 153_S 3.095 1.00
94_A 138_A 2.913 1.00
30_A 192_H 2.855 1.00
48_F 111_L 2.808 1.00
75_G 138_A 2.802 1.00
124_G 171_T 2.625 1.00
49_A 96_A 2.599 1.00
45_I 98_R 2.529 1.00
63_L 106_I 2.528 1.00
141_P 147_D 2.483 1.00
47_I 142_L 2.465 1.00
74_T 96_A 2.385 1.00
63_L 114_V 2.38 1.00
141_P 176_N 2.314 1.00
50_M 56_V 2.302 1.00
11_S 14_D 2.075 1.00
84_R 186_D 2.038 1.00
200_G 203_G 2.013 1.00
53_F 73_Y 2.012 1.00
44_E 143_T 2.011 1.00
119_H 137_S 1.993 1.00
158_Q 162_L 1.992 1.00
154_L 174_I 1.91 1.00
140_Y 173_E 1.842 1.00
44_E 146_Q 1.836 1.00
50_M 118_N 1.832 1.00
48_F 108_Y 1.779 1.00
39_V 182_Y 1.737 0.99
94_A 136_R 1.693 0.99
9_L 77_Y 1.656 0.99
109_E 149_A 1.621 0.99
55_G 191_L 1.589 0.99
108_Y 146_Q 1.503 0.98
70_A 98_R 1.484 0.98
112_L 116_W 1.475 0.98
147_D 176_N 1.461 0.97
44_E 101_Y 1.447 0.97
102_D 105_V 1.445 0.97
43_M 67_Y 1.425 0.97
58_R 200_G 1.423 0.97
56_V 118_N 1.402 0.96
47_I 96_A 1.393 0.96
64_P 105_V 1.385 0.96
185_D 193_K 1.384 0.96
151_R 154_L 1.336 0.95
47_I 74_T 1.325 0.95
78_T 85_E 1.279 0.93
139_I 150_A 1.277 0.93
138_A 175_A 1.257 0.92
47_I 98_R 1.235 0.91
87_C 134_Q 1.207 0.90
56_V 71_A 1.193 0.89
61_W 69_T 1.192 0.89
109_E 152_A 1.189 0.89
79_P 181_Y 1.185 0.89
82_T 85_E 1.184 0.89
115_F 172_T 1.18 0.89
49_A 74_T 1.165 0.88
157_F 161_M 1.157 0.87
148_A 152_A 1.148 0.87
40_P 67_Y 1.147 0.87
116_W 154_L 1.143 0.87
70_A 182_Y 1.137 0.86
48_F 60_F 1.133 0.86
112_L 153_S 1.132 0.86
86_V 134_Q 1.126 0.85
55_G 58_R 1.124 0.85
71_A 189_Q 1.123 0.85
94_A 175_A 1.122 0.85
160_A 163_A 1.11 0.84
18_G 85_E 1.107 0.84
86_V 91_T 1.084 0.82
162_L 168_R 1.082 0.82
58_R 202_G 1.071 0.81
146_Q 150_A 1.071 0.81
47_I 177_A 1.067 0.81
207_C 210_P 1.064 0.81
125_M 133_T 1.038 0.78
19_R 85_E 1.034 0.78
34_H 67_Y 1.033 0.78
152_A 156_R 1.033 0.78
144_P 147_D 1.029 0.78
126_R 131_H 1.019 0.77
58_R 199_C 1.01 0.76
126_R 136_R 1.005 0.75
28_L 36_M 1.002 0.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1ff3A30.99531000.077Contact Map0.8
1fvgA10.91981000.129Contact Map0.833
2j89A10.9671000.217Contact Map0.81
3bqhA10.7831000.224Contact Map0.688
3e0mA40.77361000.232Contact Map0.748
3pimA30.81131000.235Contact Map0.631
4gwbA10.76891000.275Contact Map0.724
1nwaA10.87261000.278Contact Map0.703
2ldiA10.301986.90.946Contact Map0.302
1opzA10.325586.90.946Contact Map0.473
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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