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OPENSEQ.org
LPXC - UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
UniProt: P0A725 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10265
Length: 305 (295)
Sequences: 887
Seq/Len: 3.01
LPXC
Paralog alert: 0.02 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
82_A 182_F 5.698 1.00
137_R 146_E 3.869 1.00
28_L 92_I 3.086 1.00
116_L 183_M 2.962 1.00
66_L 77_V 2.88 1.00
33_A 123_L 2.871 1.00
210_G 217_V 2.625 1.00
4_Q 91_N 2.581 1.00
84_L 92_I 2.476 1.00
96_V 101_I 2.399 1.00
35_T 93_V 2.337 1.00
154_S 257_A 2.302 1.00
25_T 97_N 2.292 1.00
52_A 249_M 2.222 1.00
77_V 81_N 2.109 1.00
84_L 94_I 2.08 1.00
40_R 93_V 2.036 1.00
274_A 277_A 1.997 1.00
132_I 256_G 1.992 1.00
40_R 95_E 1.986 1.00
29_R 95_E 1.977 1.00
8_K 121_D 1.955 1.00
134_E 278_K 1.929 0.99
157_F 263_S 1.909 0.99
188_R 231_F 1.903 0.99
200_Y 204_R 1.898 0.99
260_A 263_S 1.883 0.99
148_K 259_T 1.863 0.99
269_N 273_Q 1.781 0.99
90_D 127_K 1.774 0.99
91_N 123_L 1.717 0.98
10_I 29_R 1.714 0.98
58_R 67_V 1.705 0.98
41_R 44_L 1.674 0.98
135_T 148_K 1.666 0.98
156_D 172_R 1.659 0.98
89_I 120_I 1.653 0.98
131_R 283_E 1.651 0.98
138_V 267_L 1.621 0.98
103_I 216_I 1.617 0.98
5_R 123_L 1.607 0.97
210_G 215_A 1.601 0.97
248_F 262_K 1.598 0.97
158_T 261_Y 1.539 0.96
9_R 118_A 1.535 0.96
218_V 235_F 1.52 0.96
148_K 257_A 1.517 0.96
86_G 112_V 1.505 0.96
13_A 114_L 1.504 0.96
200_Y 203_S 1.494 0.96
4_Q 34_N 1.454 0.95
7_L 92_I 1.451 0.95
92_I 115_L 1.447 0.94
243_A 258_F 1.444 0.94
28_L 115_L 1.435 0.94
113_Y 117_D 1.428 0.94
37_V 92_I 1.427 0.94
142_D 262_K 1.422 0.94
156_D 174_A 1.417 0.94
147_F 258_F 1.411 0.93
186_I 240_M 1.407 0.93
163_H 194_F 1.405 0.93
12_Q 27_T 1.383 0.93
147_F 256_G 1.382 0.92
35_T 38_I 1.381 0.92
59_D 73_R 1.376 0.92
274_A 278_K 1.369 0.92
163_H 218_V 1.358 0.92
11_V 28_L 1.357 0.92
18_L 210_G 1.345 0.91
34_N 125_C 1.337 0.91
28_L 80_L 1.334 0.91
57_V 60_T 1.331 0.91
51_P 56_S 1.328 0.90
87_L 112_V 1.323 0.90
89_I 92_I 1.302 0.89
40_R 49_D 1.274 0.88
266_A 270_K 1.266 0.87
18_L 215_A 1.256 0.87
19_H 76_T 1.25 0.86
32_P 35_T 1.239 0.86
158_T 172_R 1.237 0.86
139_E 146_E 1.231 0.85
223_V 228_G 1.221 0.85
206_L 215_A 1.217 0.84
147_F 275_V 1.216 0.84
156_D 257_A 1.21 0.84
7_L 115_L 1.208 0.84
44_L 72_V 1.207 0.84
198_I 205_G 1.179 0.82
37_V 94_I 1.176 0.82
63_C 198_I 1.173 0.81
54_A 272_L 1.172 0.81
216_I 229_L 1.172 0.81
198_I 210_G 1.169 0.81
74_I 96_V 1.166 0.81
137_R 144_W 1.159 0.80
131_R 255_I 1.151 0.80
189_A 193_G 1.145 0.79
193_G 201_L 1.144 0.79
5_R 122_E 1.128 0.78
146_E 259_T 1.121 0.77
166_I 171_Q 1.119 0.77
14_T 25_T 1.119 0.77
189_A 231_F 1.115 0.77
24_V 98_A 1.114 0.76
54_A 276_L 1.111 0.76
145_A 271_L 1.109 0.76
31_A 35_T 1.109 0.76
293_L 296_A 1.108 0.76
145_A 243_A 1.108 0.76
150_Y 154_S 1.105 0.76
152_G 176_N 1.104 0.76
44_L 108_A 1.092 0.74
134_E 280_E 1.085 0.74
4_Q 90_D 1.084 0.74
147_F 243_A 1.079 0.73
159_I 192_F 1.077 0.73
139_E 142_D 1.076 0.73
289_D 292_E 1.075 0.73
187_S 282_W 1.071 0.72
109_A 187_S 1.069 0.72
197_D 205_G 1.065 0.72
33_A 125_C 1.059 0.71
84_L 89_I 1.057 0.71
38_I 93_V 1.055 0.71
26_L 96_V 1.048 0.70
27_T 95_E 1.047 0.70
263_S 268_N 1.034 0.69
80_L 101_I 1.033 0.68
138_V 271_L 1.028 0.68
51_P 68_N 1.025 0.68
135_T 146_E 1.024 0.67
161_F 192_F 1.024 0.67
51_P 54_A 1.02 0.67
157_F 243_A 1.016 0.67
275_V 281_A 1.013 0.66
194_F 218_V 1.012 0.66
170_N 291_A 1.01 0.66
169_S 295_L 1.008 0.66
294_P 297_F 1.005 0.65
197_D 200_Y 1.003 0.65
250_C 253_N 1.003 0.65
114_L 117_D 1.003 0.65
38_I 49_D 1.003 0.65
199_E 203_S 1 0.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3p3gA10.98361000.032Contact Map0.759
3uhmA10.98031000.033Contact Map0.78
3p3cA10.89841000.087Contact Map0.725
3bpuA10.288513.40.976Contact Map0.075
1darA10.6066100.978Contact Map0.532
4fn5A10.60987.30.979Contact Map0.4
3u7zA20.324670.979Contact Map0.097
3r2cJ20.24596.90.979Contact Map0.219
3qe1A10.34756.50.979Contact Map0.06
3soeA10.36396.50.979Contact Map0.125
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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