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OPENSEQ.org

LPXA - Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
UniProt: P0A722 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10545
Length: 262 (259)
Sequences: 1834
Seq/Len: 7.08

LPXA
Paralog alert: 0.60 [within 20: 0.54] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
59_D 89_R 4.405 1.00
21_G 40_E 3.921 1.00
89_R 114_D 3.563 1.00
30_C 44_L 3.22 1.00
19_S 37_E 3.135 1.00
15_E 34_P 2.822 1.00
41_G 59_D 2.738 1.00
20_I 26_I 2.652 1.00
237_A 254_A 2.65 1.00
113_S 131_N 2.6 1.00
25_H 43_V 2.565 1.00
58_R 88_D 2.557 1.00
131_N 149_D 2.509 1.00
114_D 132_R 2.4 1.00
150_F 168_H 2.357 1.00
130_G 149_D 2.342 1.00
37_E 55_K 2.328 1.00
30_C 48_V 2.269 1.00
129_V 133_C 2.262 1.00
23_N 40_E 2.204 1.00
112_G 131_N 2.196 1.00
20_I 24_A 2.174 1.00
88_D 113_S 2.104 1.00
211_A 245_E 2.062 1.00
62_I 66_A 2.048 1.00
60_N 90_N 2.031 1.00
132_R 150_F 2.008 1.00
62_I 92_I 1.94 1.00
38_I 42_T 1.936 1.00
23_N 41_G 1.935 1.00
11_T 29_F 1.872 1.00
168_H 205_R 1.83 1.00
153_I 159_V 1.815 1.00
39_G 58_R 1.785 1.00
56_I 62_I 1.761 1.00
35_H 53_H 1.749 1.00
43_V 61_E 1.71 1.00
40_E 58_R 1.706 1.00
247_K 251_D 1.702 1.00
26_I 30_C 1.697 1.00
149_D 167_A 1.671 1.00
117_L 121_A 1.644 1.00
42_T 60_N 1.604 1.00
22_A 40_E 1.584 1.00
29_F 47_H 1.58 1.00
148_D 167_A 1.579 1.00
140_T 158_A 1.574 1.00
92_I 98_I 1.567 1.00
95_S 120_N 1.55 1.00
146_S 164_I 1.541 0.99
84_V 98_I 1.519 0.99
228_T 231_E 1.516 0.99
21_G 24_A 1.481 0.99
148_D 248_A 1.478 0.99
183_P 252_F 1.473 0.99
42_T 56_I 1.458 0.99
110_K 128_T 1.456 0.99
98_I 117_L 1.455 0.99
17_G 34_P 1.429 0.99
90_N 115_N 1.41 0.99
118_M 136_A 1.409 0.99
140_T 156_M 1.402 0.99
233_K 253_F 1.399 0.99
45_K 61_E 1.389 0.99
35_H 81_P 1.358 0.98
135_L 139_A 1.351 0.98
160_H 258_R 1.346 0.98
24_A 42_T 1.345 0.98
152_I 170_M 1.335 0.98
85_E 110_K 1.332 0.98
68_I 84_V 1.316 0.98
159_V 165_I 1.308 0.98
82_T 107_G 1.3 0.98
44_L 50_V 1.297 0.98
68_I 98_I 1.296 0.98
41_G 58_R 1.288 0.98
44_L 48_V 1.285 0.98
17_G 35_H 1.273 0.97
117_L 123_I 1.255 0.97
170_M 186_I 1.252 0.97
229_L 233_K 1.25 0.97
50_V 54_T 1.242 0.97
85_E 108_L 1.237 0.97
167_A 248_A 1.228 0.96
130_G 146_S 1.204 0.96
83_R 108_L 1.2 0.96
9_H 13_I 1.198 0.96
222_I 253_F 1.179 0.95
62_I 68_I 1.171 0.95
32_V 44_L 1.169 0.95
61_E 71_V 1.156 0.95
227_K 232_V 1.148 0.94
177_V 181_V 1.142 0.94
202_L 215_I 1.131 0.94
51_N 70_E 1.128 0.94
222_I 249_F 1.115 0.93
66_A 96_V 1.115 0.93
75_L 116_L 1.114 0.93
59_D 114_D 1.111 0.93
214_A 246_V 1.107 0.93
112_G 128_T 1.08 0.92
158_A 173_G 1.077 0.91
158_A 174_C 1.077 0.91
105_G 191_H 1.061 0.91
221_L 236_I 1.06 0.91
97_T 120_N 1.059 0.91
28_P 46_S 1.053 0.90
166_G 182_P 1.049 0.90
24_A 58_R 1.046 0.90
250_T 254_A 1.044 0.90
21_G 39_G 1.037 0.89
38_I 50_V 1.028 0.89
42_T 88_D 1.016 0.88
65_F 95_S 1.01 0.88
151_A 167_A 1.01 0.88
12_A 30_C 1.009 0.87
251_D 254_A 1.006 0.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1j2zA10.98091000.286Contact Map0.839
3t57A10.99621000.314Contact Map0.756
4eqyA611000.32Contact Map0.876
3r0sA10.98091000.324Contact Map0.843
2qiaA111000.325Contact Map0.814
4e6uA111000.327Contact Map0.856
3hsqA30.97711000.329Contact Map0.865
2iu8A30.8741000.518Contact Map0.831
3pmoA10.88551000.519Contact Map0.786
3fs8A20.93511000.533Contact Map0.751

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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