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OPENSEQ.org
KPRS - Ribose-phosphate pyrophosphokinase
UniProt: P0A717 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10774
Length: 315 (311)
Sequences: 2056
Seq/Len: 6.61
KPRS
Paralog alert: 0.27 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
18_R 273_D 4.891 1.00
243_R 267_D 4.441 1.00
268_E 288_R 4.219 1.00
67_L 113_V 3.458 1.00
259_N 263_N 3.38 1.00
74_V 122_V 3.181 1.00
6_L 20_A 2.983 1.00
7_F 28_G 2.946 1.00
256_N 260_N 2.914 1.00
215_D 243_R 2.89 1.00
17_Q 21_N 2.889 1.00
234_E 238_E 2.862 1.00
22_R 297_A 2.818 1.00
298_E 302_R 2.704 1.00
72_V 109_T 2.515 1.00
231_K 234_E 2.502 1.00
273_D 291_T 2.463 1.00
215_D 242_K 2.431 1.00
13_P 17_Q 2.397 1.00
55_I 77_L 2.338 1.00
11_A 58_S 2.286 1.00
34_R 65_D 2.278 1.00
128_V 274_T 2.238 1.00
128_V 296_L 2.194 1.00
251_P 271_V 2.188 1.00
60_C 276_P 2.154 1.00
117_L 122_V 2.125 1.00
19_I 56_I 2.123 1.00
29_D 45_N 2.105 1.00
6_L 56_I 2.061 1.00
10_N 32_V 2.055 1.00
112_V 120_V 2.024 1.00
128_V 292_L 1.976 1.00
126_L 303_I 1.946 1.00
166_V 177_A 1.935 1.00
224_D 254_S 1.926 1.00
234_E 265_V 1.916 1.00
253_F 269_V 1.911 1.00
165_I 214_R 1.901 1.00
14_E 18_R 1.871 1.00
226_G 230_C 1.868 1.00
237_K 267_D 1.864 1.00
59_T 93_G 1.855 1.00
279_D 282_K 1.817 1.00
115_D 140_D 1.746 1.00
284_L 287_V 1.743 1.00
262_R 285_P 1.735 1.00
223_I 248_A 1.731 1.00
164_P 187_T 1.725 1.00
223_I 269_V 1.712 1.00
5_K 51_G 1.675 1.00
159_L 268_E 1.668 1.00
167_V 216_C 1.623 1.00
52_D 84_R 1.592 1.00
274_T 292_L 1.583 1.00
8_A 16_A 1.582 1.00
89_I 117_L 1.563 0.99
261_L 269_V 1.562 0.99
262_R 284_L 1.56 0.99
245_F 267_D 1.537 0.99
213_G 242_K 1.533 0.99
146_V 299_A 1.53 0.99
164_P 217_V 1.526 0.99
229_L 246_A 1.524 0.99
246_A 266_I 1.518 0.99
256_N 259_N 1.499 0.99
14_E 17_Q 1.492 0.99
50_G 306_E 1.461 0.99
16_A 27_L 1.443 0.99
215_D 245_F 1.441 0.99
168_S 173_G 1.44 0.99
20_A 26_S 1.438 0.99
18_R 293_S 1.437 0.99
202_S 231_K 1.422 0.99
154_E 158_Q 1.385 0.98
216_C 236_L 1.379 0.98
15_L 296_L 1.346 0.98
167_V 190_A 1.328 0.98
172_G 196_R 1.328 0.98
37_D 91_Y 1.324 0.98
155_D 288_R 1.311 0.98
233_A 266_I 1.31 0.98
251_P 277_L 1.297 0.97
237_K 265_V 1.285 0.97
198_R 201_V 1.284 0.97
172_G 194_K 1.278 0.97
20_A 27_L 1.268 0.97
223_I 229_L 1.268 0.97
161_L 164_P 1.255 0.97
156_M 217_V 1.243 0.96
53_I 77_L 1.242 0.96
204_V 235_A 1.235 0.96
245_F 268_E 1.212 0.96
194_K 227_G 1.205 0.95
31_A 45_N 1.197 0.95
156_M 270_V 1.196 0.95
173_G 176_R 1.186 0.95
9_G 57_Q 1.183 0.95
212_A 239_R 1.175 0.95
152_L 290_L 1.152 0.94
218_L 232_A 1.141 0.93
30_A 73_M 1.138 0.93
48_V 77_L 1.137 0.93
305_N 311_A 1.136 0.93
226_G 256_N 1.135 0.93
155_D 290_L 1.132 0.93
22_R 294_G 1.13 0.93
160_N 163_N 1.123 0.93
7_F 73_M 1.12 0.92
18_R 291_T 1.114 0.92
171_I 175_V 1.105 0.92
223_I 253_F 1.102 0.92
31_A 43_Q 1.101 0.92
301_R 305_N 1.098 0.91
36_S 224_D 1.096 0.91
279_D 283_S 1.091 0.91
230_C 260_N 1.089 0.91
298_E 301_R 1.084 0.91
278_S 281_I 1.083 0.91
37_D 99_R 1.076 0.90
170_D 196_R 1.075 0.90
163_N 242_K 1.075 0.90
23_L 297_A 1.072 0.90
163_N 215_D 1.069 0.90
248_A 271_V 1.065 0.90
152_L 247_Y 1.064 0.90
301_R 307_E 1.057 0.89
223_I 226_G 1.057 0.89
153_L 180_I 1.049 0.89
167_V 236_L 1.038 0.88
241_A 244_V 1.038 0.88
4_M 304_S 1.037 0.88
172_G 227_G 1.031 0.88
156_M 180_I 1.029 0.88
196_R 227_G 1.024 0.87
307_E 311_A 1.023 0.87
89_I 125_V 1.022 0.87
155_D 268_E 1.016 0.87
129_D 249_T 1.015 0.87
101_V 106_V 1.014 0.87
200_N 224_D 1.011 0.86
118_S 141_V 1.009 0.86
18_R 21_N 1.003 0.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2ji4A10.99051000.115Contact Map0.817
3s5jB20.99371000.123Contact Map0.827
1dkuA20.98731000.13Contact Map0.835
3dahA30.99371000.145Contact Map0.843
1u9yA40.90161000.213Contact Map0.795
3lrtA20.90791000.219Contact Map0.667
3dezA20.72381000.7Contact Map0.451
1o57A40.834999.90.733Contact Map0.401
3m3hA10.688999.90.75Contact Map0.502
2aeeA20.622299.80.778Contact Map0.496
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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