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OPENSEQ.org
KDSA - 2-dehydro-3-deoxyphosphooctonate aldolase
UniProt: P0A715 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10518
Length: 284 (272)
Sequences: 1700
Seq/Len: 6.25
KDSA
Paralog alert: 0.19 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
243_D 246_H 5.582 1.00
31_R 83_E 5.091 1.00
114_L 128_M 3.332 1.00
21_L 264_L 3.003 1.00
82_Q 86_Q 2.891 1.00
111_V 164_I 2.76 1.00
47_K 261_E 2.757 1.00
76_E 79_K 2.743 1.00
7_S 10_D 2.68 1.00
197_I 235_G 2.553 1.00
7_S 12_N 2.537 1.00
137_V 155_F 2.509 1.00
226_R 266_Q 2.25 1.00
100_S 127_A 2.172 1.00
37_I 242_P 2.171 1.00
156_K 163_V 2.152 1.00
189_K 219_A 2.126 1.00
251_G 254_A 2.065 1.00
58_F 101_Q 2.052 1.00
94_T 109_V 2.026 1.00
119_A 143_V 1.982 1.00
187_M 191_S 1.979 1.00
271_D 275_K 1.971 1.00
215_G 224_L 1.95 1.00
35_M 88_F 1.948 1.00
270_I 274_V 1.867 1.00
30_S 33_L 1.847 1.00
99_P 102_A 1.842 1.00
270_I 273_L 1.809 1.00
34_A 80_I 1.8 1.00
96_V 102_A 1.792 1.00
105_V 109_V 1.783 1.00
56_A 62_N 1.758 1.00
19_F 229_M 1.723 1.00
176_N 206_C 1.718 1.00
83_E 87_T 1.715 1.00
19_F 271_D 1.714 1.00
22_F 93_I 1.686 1.00
181_M 224_L 1.677 1.00
152_V 165_L 1.623 1.00
96_V 112_I 1.619 1.00
218_R 245_E 1.604 1.00
125_V 155_F 1.599 1.00
129_A 158_G 1.579 0.99
94_T 105_V 1.57 0.99
35_M 87_T 1.553 0.99
218_R 259_K 1.551 0.99
148_M 187_M 1.536 0.99
82_Q 85_K 1.533 0.99
184_F 198_F 1.53 0.99
39_E 87_T 1.517 0.99
31_R 35_M 1.516 0.99
13_V 111_V 1.505 0.99
40_H 258_A 1.504 0.99
39_E 43_T 1.504 0.99
145_P 183_G 1.502 0.99
187_M 196_V 1.495 0.99
104_P 108_V 1.486 0.99
85_K 92_I 1.479 0.99
35_M 83_E 1.422 0.99
102_A 131_T 1.419 0.99
36_R 39_E 1.418 0.99
222_A 266_Q 1.399 0.98
40_H 43_T 1.398 0.98
156_K 194_S 1.396 0.98
269_A 273_L 1.396 0.98
39_E 88_F 1.395 0.98
32_D 36_R 1.395 0.98
85_K 88_F 1.383 0.98
79_K 108_V 1.38 0.98
261_E 265_K 1.374 0.98
75_E 104_P 1.373 0.98
38_C 90_V 1.358 0.98
101_Q 123_D 1.354 0.98
52_Y 90_V 1.324 0.97
186_I 220_Q 1.323 0.97
256_P 259_K 1.315 0.97
82_Q 108_V 1.311 0.97
28_L 81_F 1.308 0.97
92_I 109_V 1.307 0.97
174_Y 177_L 1.294 0.97
23_G 240_A 1.277 0.97
44_V 261_E 1.242 0.96
98_E 123_D 1.24 0.96
53_V 111_V 1.239 0.96
155_F 160_N 1.233 0.96
35_M 39_E 1.23 0.96
41_Y 52_Y 1.229 0.96
33_L 242_P 1.22 0.95
104_P 107_D 1.216 0.95
262_P 266_Q 1.208 0.95
35_M 84_L 1.204 0.95
128_M 135_I 1.195 0.95
225_A 267_M 1.188 0.94
130_K 158_G 1.182 0.94
85_K 108_V 1.175 0.94
22_F 197_I 1.167 0.94
163_V 194_S 1.162 0.93
30_S 248_K 1.16 0.93
83_E 86_Q 1.155 0.93
172_F 175_D 1.151 0.93
103_Q 107_D 1.143 0.93
132_G 162_K 1.143 0.93
41_Y 260_L 1.14 0.93
210_F 213_A 1.133 0.92
238_I 263_F 1.12 0.92
116_A 249_C 1.117 0.92
198_F 224_L 1.111 0.91
167_D 170_A 1.092 0.90
129_A 155_F 1.089 0.90
42_V 46_Q 1.087 0.90
36_R 242_P 1.082 0.90
97_H 123_D 1.076 0.89
11_I 20_V 1.076 0.89
146_G 175_D 1.075 0.89
22_F 53_V 1.071 0.89
268_K 272_D 1.07 0.89
262_P 265_K 1.07 0.89
126_E 158_G 1.069 0.89
79_K 82_Q 1.062 0.89
40_H 44_V 1.061 0.89
184_F 231_V 1.059 0.88
170_A 183_G 1.048 0.88
37_I 54_F 1.038 0.87
48_L 111_V 1.028 0.86
5_V 12_N 1.025 0.86
127_A 130_K 1.022 0.86
217_R 220_Q 1.018 0.86
97_H 101_Q 1.014 0.85
72_P 77_G 1.013 0.85
19_F 50_I 1.003 0.85
143_V 151_I 1.001 0.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4lu0A40.98941000.309Contact Map0.809
2qkfA40.98591000.313Contact Map0.811
1o60A411000.314Contact Map0.792
3sz8A40.98591000.314Contact Map0.71
3fs2A20.96831000.316Contact Map0.745
3tmlA40.98941000.318Contact Map0.747
2nwrA20.93661000.35Contact Map0.738
1vr6A40.9121000.352Contact Map0.82
3nvtA20.90851000.381Contact Map0.667
1vs1A40.89081000.405Contact Map0.802
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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