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OPENSEQ.org
GCH1 - GTP cyclohydrolase 1
UniProt: P0A6T5 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11375
Length: 222 (193)
Sequences: 1520
Seq/Len: 7.88
GCH1
Paralog alert: 0.09 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
124_V 138_I 3.237 1.00
41_A 65_H 3.071 1.00
40_I 47_I 2.948 1.00
81_Y 85_P 2.82 1.00
65_H 69_K 2.714 1.00
62_E 65_H 2.591 1.00
37_K 73_D 2.312 1.00
125_A 173_A 2.246 1.00
97_D 205_K 2.198 1.00
75_I 116_V 2.144 1.00
83_N 87_I 2.038 1.00
45_T 56_A 2.023 1.00
107_L 178_A 2.022 1.00
122_A 176_I 2.003 1.00
81_Y 84_F 1.927 1.00
43_H 46_E 1.899 1.00
81_Y 86_K 1.862 1.00
38_S 41_A 1.821 1.00
71_Y 76_F 1.804 1.00
79_L 149_P 1.794 1.00
161_I 201_G 1.785 1.00
39_L 46_E 1.761 1.00
39_L 49_Q 1.747 1.00
99_M 204_F 1.658 1.00
44_M 67_I 1.657 1.00
42_G 46_E 1.642 1.00
173_A 200_L 1.625 1.00
53_L 57_D 1.579 1.00
43_H 50_L 1.573 1.00
145_F 158_Q 1.572 1.00
48_M 53_L 1.561 1.00
46_E 49_Q 1.526 1.00
121_K 177_D 1.489 0.99
160_L 201_G 1.485 0.99
143_Q 190_D 1.477 0.99
83_N 86_K 1.474 0.99
141_I 163_L 1.464 0.99
125_A 214_F 1.463 0.99
175_S 218_V 1.462 0.99
115_F 149_P 1.453 0.99
82_A 85_P 1.432 0.99
123_T 177_D 1.43 0.99
124_V 142_V 1.424 0.99
99_M 214_F 1.415 0.99
129_K 170_N 1.409 0.99
170_N 203_L 1.405 0.99
107_L 142_V 1.405 0.99
122_A 159_I 1.389 0.99
173_A 214_F 1.377 0.99
203_L 207_S 1.359 0.99
135_L 195_T 1.357 0.99
45_T 55_L 1.352 0.99
99_M 210_T 1.35 0.99
108_T 185_A 1.348 0.99
48_M 115_F 1.329 0.99
81_Y 87_I 1.297 0.98
198_T 210_T 1.295 0.98
175_S 214_F 1.284 0.98
127_I 203_L 1.269 0.98
209_N 212_H 1.266 0.98
148_R 158_Q 1.238 0.97
45_T 49_Q 1.226 0.97
157_Q 161_I 1.22 0.97
108_T 181_Y 1.22 0.97
74_E 189_R 1.201 0.97
181_Y 185_A 1.196 0.97
40_I 68_A 1.196 0.97
80_D 84_F 1.175 0.96
46_E 50_L 1.173 0.96
97_D 170_N 1.169 0.96
145_F 162_A 1.158 0.96
179_V 192_T 1.15 0.95
106_T 192_T 1.147 0.95
145_F 155_L 1.144 0.95
137_K 140_R 1.14 0.95
204_F 214_F 1.138 0.95
212_H 216_R 1.115 0.94
99_M 125_A 1.106 0.94
107_L 176_I 1.101 0.94
53_L 59_S 1.099 0.94
55_L 60_L 1.097 0.94
44_M 47_I 1.084 0.93
175_S 198_T 1.077 0.93
143_Q 147_Q 1.074 0.93
44_M 71_Y 1.065 0.92
163_L 167_L 1.065 0.92
90_I 93_K 1.06 0.92
177_D 194_A 1.058 0.92
208_Q 212_H 1.054 0.92
203_L 206_S 1.052 0.92
80_D 85_P 1.041 0.91
32_D 35_T 1.04 0.91
76_F 110_T 1.039 0.91
132_V 151_V 1.035 0.91
179_V 184_K 1.029 0.91
151_V 195_T 1.024 0.90
78_G 148_R 1.02 0.90
82_A 87_I 1.018 0.90
198_T 213_E 1.015 0.90
131_S 168_G 1.001 0.89
90_I 94_M 1.001 0.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1a8rA150.99551000.045Contact Map0.618
1is8A100.9551000.108Contact Map0.779
1wurA50.94141000.16Contact Map0.71
4f8bA50.6937990.851Contact Map0.647
1w5dA10.653210.90.968Contact Map0.288
3uxjA40.87848.80.969Contact Map0.554
2q2kA20.24327.80.97Contact Map0.427
1nbuA50.45057.50.97Contact Map0.506
1w79A40.79737.20.97Contact Map0.326
1b9lA80.45956.10.971Contact Map0.32
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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