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OPENSEQ.org
G6PI - Glucose-6-phosphate isomerase
UniProt: P0A6T1 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10702
Length: 549 (544)
Sequences: 1261
Seq/Len: 2.32
G6PI
Paralog alert: 0.07 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
74_D 77_G 4.389 1.00
497_G 504_T 4.035 1.00
18_H 62_T 3.771 1.00
249_A 252_E 3.381 1.00
336_L 389_Y 3.355 1.00
324_Y 328_F 2.995 1.00
405_A 421_L 2.97 1.00
71_K 76_A 2.962 1.00
62_T 65_K 2.838 1.00
18_H 65_K 2.808 1.00
273_L 293_L 2.715 1.00
128_K 291_V 2.701 1.00
408_I 476_E 2.638 1.00
189_I 221_S 2.628 1.00
309_A 315_V 2.618 1.00
325_N 397_K 2.58 1.00
87_K 93_N 2.571 1.00
11_A 72_E 2.54 1.00
71_K 310_E 2.529 1.00
404_I 474_L 2.487 1.00
145_K 199_E 2.485 1.00
437_R 458_V 2.451 1.00
149_D 179_H 2.393 1.00
352_G 493_I 2.384 1.00
344_R 347_A 2.353 1.00
344_R 379_E 2.334 1.00
56_N 470_N 2.311 1.00
76_A 79_I 2.303 1.00
40_K 60_E 2.286 1.00
224_D 228_K 2.266 1.00
289_N 292_E 2.259 1.00
76_A 309_A 2.247 1.00
88_I 96_V 2.236 1.00
19_F 328_F 2.228 1.00
99_V 109_I 2.219 1.00
360_Y 464_E 2.181 1.00
429_E 533_H 2.175 1.00
38_F 539_G 2.175 1.00
80_K 305_S 2.174 1.00
302_K 306_T 2.043 0.99
425_F 544_Y 2.031 0.99
330_A 398_M 2.03 0.99
362_D 366_N 2.014 0.99
114_K 119_E 1.993 0.99
96_V 504_T 1.972 0.99
75_L 79_I 1.97 0.99
36_D 39_S 1.957 0.99
206_A 277_I 1.954 0.99
299_A 480_F 1.944 0.99
292_E 480_F 1.943 0.99
336_L 401_C 1.916 0.99
80_K 84_S 1.899 0.99
368_V 372_T 1.88 0.99
319_L 499_I 1.868 0.99
51_V 313_L 1.866 0.99
78_A 363_R 1.857 0.99
151_V 203_F 1.857 0.99
451_P 454_L 1.839 0.98
149_D 200_T 1.81 0.98
149_D 177_N 1.796 0.98
441_E 455_D 1.78 0.98
130_F 261_F 1.78 0.98
83_F 305_S 1.772 0.98
26_T 29_D 1.769 0.98
424_F 471_S 1.756 0.98
424_F 428_T 1.739 0.98
38_F 50_L 1.73 0.98
331_E 397_K 1.728 0.97
251_G 257_T 1.724 0.97
14_A 65_K 1.722 0.97
63_L 316_L 1.717 0.97
379_E 388_F 1.705 0.97
51_V 317_L 1.704 0.97
106_N 121_N 1.693 0.97
34_D 40_K 1.692 0.97
435_K 443_E 1.684 0.97
167_E 343_H 1.671 0.97
321_G 353_N 1.661 0.97
313_L 488_L 1.649 0.96
523_E 533_H 1.646 0.96
75_L 315_V 1.639 0.96
436_S 439_V 1.638 0.96
148_T 200_T 1.632 0.96
425_F 473_L 1.623 0.96
26_T 57_R 1.619 0.96
336_L 384_G 1.605 0.96
248_K 252_E 1.603 0.96
317_L 488_L 1.599 0.96
139_W 147_I 1.585 0.95
247_A 257_T 1.585 0.95
418_Q 544_Y 1.584 0.95
392_I 399_V 1.584 0.95
131_S 287_F 1.582 0.95
56_N 324_Y 1.575 0.95
14_A 68_D 1.575 0.95
43_A 313_L 1.567 0.95
133_A 138_E 1.562 0.95
244_S 250_V 1.561 0.95
103_N 117_M 1.561 0.95
115_D 118_P 1.559 0.95
173_K 284_S 1.555 0.95
51_V 470_N 1.554 0.95
384_G 389_Y 1.55 0.94
192_V 196_V 1.549 0.94
335_I 349_F 1.548 0.94
302_K 305_S 1.538 0.94
191_E 341_Y 1.535 0.94
206_A 243_L 1.533 0.94
273_L 281_I 1.529 0.94
46_D 299_A 1.526 0.94
204_L 243_L 1.526 0.94
363_R 501_N 1.525 0.94
79_I 309_A 1.52 0.94
444_Y 461_K 1.52 0.94
108_P 115_D 1.517 0.94
221_S 416_H 1.512 0.93
457_V 461_K 1.51 0.93
43_A 53_Y 1.509 0.93
250_V 260_M 1.492 0.93
68_D 71_K 1.485 0.93
230_A 235_H 1.484 0.93
371_Q 397_K 1.483 0.93
226_F 230_A 1.483 0.93
131_S 283_L 1.479 0.92
81_S 86_E 1.473 0.92
282_V 287_F 1.473 0.92
428_T 471_S 1.468 0.92
274_W 297_A 1.465 0.92
405_A 424_F 1.45 0.91
59_T 62_T 1.436 0.91
543_R 547_W 1.435 0.91
217_T 419_K 1.426 0.90
389_Y 401_C 1.426 0.90
51_V 472_I 1.425 0.90
71_K 309_A 1.423 0.90
131_S 282_V 1.415 0.90
159_D 163_Y 1.403 0.90
104_R 121_N 1.403 0.90
78_A 498_V 1.401 0.89
347_A 379_E 1.39 0.89
430_A 516_L 1.389 0.89
357_N 504_T 1.386 0.89
429_E 523_E 1.375 0.88
198_P 229_A 1.358 0.87
82_M 88_I 1.349 0.87
538_N 542_N 1.346 0.87
16_Q 20_D 1.345 0.87
520_I 523_E 1.345 0.87
128_K 287_F 1.343 0.87
181_V 222_A 1.343 0.87
437_R 441_E 1.342 0.87
246_N 249_A 1.34 0.86
78_A 81_S 1.337 0.86
408_I 475_R 1.33 0.86
247_A 260_M 1.315 0.85
181_V 189_I 1.313 0.85
58_I 63_L 1.3 0.84
143_T 199_E 1.298 0.84
107_T 302_K 1.295 0.84
141_G 147_I 1.289 0.83
131_S 135_I 1.286 0.83
171_P 410_H 1.285 0.83
322_I 499_I 1.283 0.83
437_R 462_V 1.278 0.83
87_K 112_D 1.277 0.83
307_T 311_K 1.275 0.83
41_F 60_E 1.273 0.82
232_D 235_H 1.271 0.82
28_A 439_V 1.263 0.82
53_Y 63_L 1.26 0.81
75_L 318_A 1.256 0.81
42_S 50_L 1.255 0.81
67_Q 316_L 1.254 0.81
68_D 72_E 1.253 0.81
451_P 455_D 1.248 0.81
404_I 477_I 1.247 0.81
203_F 222_A 1.241 0.80
186_G 416_H 1.241 0.80
109_I 118_P 1.24 0.80
44_T 47_D 1.24 0.80
41_F 58_I 1.239 0.80
96_V 497_G 1.23 0.79
58_I 320_I 1.227 0.79
163_Y 343_H 1.222 0.79
29_D 33_K 1.216 0.78
149_D 197_N 1.211 0.78
90_R 363_R 1.209 0.78
321_G 492_K 1.207 0.77
198_P 225_W 1.206 0.77
125_E 291_V 1.2 0.77
82_M 96_V 1.198 0.77
77_G 81_S 1.197 0.77
103_N 108_P 1.197 0.77
135_I 283_L 1.188 0.76
323_W 327_F 1.188 0.76
165_V 293_L 1.186 0.76
474_L 481_S 1.181 0.75
21_E 61_E 1.179 0.75
247_A 251_G 1.173 0.75
353_N 373_G 1.171 0.74
38_F 42_S 1.168 0.74
344_R 380_P 1.166 0.74
6_P 73_C 1.164 0.74
300_M 488_L 1.162 0.74
179_H 192_V 1.16 0.73
104_R 298_H 1.158 0.73
22_M 25_V 1.157 0.73
64_A 68_D 1.152 0.73
151_V 201_T 1.152 0.73
300_M 313_L 1.149 0.72
44_T 543_R 1.149 0.72
50_L 543_R 1.145 0.72
27_I 57_R 1.144 0.72
67_Q 310_E 1.142 0.72
362_D 501_N 1.141 0.72
326_N 500_L 1.14 0.72
14_A 62_T 1.139 0.71
335_I 376_I 1.136 0.71
440_V 458_V 1.135 0.71
406_P 474_L 1.132 0.71
405_A 473_L 1.126 0.70
415_D 419_K 1.126 0.70
421_L 425_F 1.12 0.70
178_M 284_S 1.112 0.69
121_N 298_H 1.11 0.69
18_H 59_T 1.103 0.68
191_E 194_K 1.101 0.68
165_V 281_I 1.094 0.67
60_E 64_A 1.094 0.67
117_M 121_N 1.094 0.67
65_K 68_D 1.093 0.67
148_T 179_H 1.093 0.67
55_K 536_S 1.092 0.67
187_T 339_D 1.091 0.67
31_F 55_K 1.088 0.66
281_I 293_L 1.088 0.66
332_T 377_W 1.086 0.66
29_D 32_A 1.084 0.66
349_F 352_G 1.083 0.66
51_V 300_M 1.079 0.65
134_I 283_L 1.076 0.65
163_Y 344_R 1.074 0.65
474_L 477_I 1.073 0.65
13_Q 16_Q 1.072 0.65
108_P 117_M 1.066 0.64
480_F 484_A 1.058 0.63
373_G 391_L 1.057 0.63
428_T 469_T 1.057 0.63
475_R 484_A 1.056 0.63
129_T 133_A 1.055 0.63
407_A 543_R 1.051 0.62
105_S 125_E 1.048 0.62
333_E 353_N 1.048 0.62
167_E 341_Y 1.045 0.62
27_I 30_L 1.044 0.62
67_Q 315_V 1.044 0.62
360_Y 367_V 1.044 0.62
43_A 316_L 1.043 0.62
189_I 193_L 1.042 0.61
105_S 121_N 1.042 0.61
75_L 495_T 1.036 0.61
309_A 498_V 1.036 0.61
421_L 544_Y 1.035 0.61
6_P 9_T 1.032 0.60
367_V 464_E 1.029 0.60
213_Q 521_L 1.024 0.59
103_N 121_N 1.022 0.59
19_F 324_Y 1.021 0.59
122_A 262_E 1.02 0.59
38_F 535_S 1.013 0.58
64_A 310_E 1.009 0.58
104_R 108_P 1.005 0.57
353_N 492_K 1.005 0.57
18_H 22_M 1.004 0.57
49_M 474_L 1.001 0.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4em6D40.99641000.144Contact Map0.757
1t10A111000.146Contact Map0.679
2o2cA311000.146Contact Map0.79
3hjbA411000.153Contact Map0.777
2cxnA20.99451000.156Contact Map0.805
3ljkA10.98361000.158Contact Map0.658
3qkiA30.98181000.159Contact Map0.736
3ujhA20.981000.166Contact Map0.752
2wu8A10.97631000.171Contact Map0.668
3ff1A20.77781000.478Contact Map0.483
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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