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OPENSEQ.org
GPDA - Glycerol-3-phosphate dehydrogenase [NAD(P)+]
UniProt: P0A6S7 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG20091
Length: 339 (330)
Sequences: 2101
Seq/Len: 6.37
GPDA
Paralog alert: 0.10 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
49_C 56_D 3.408 1.00
230_G 240_F 3.387 1.00
118_R 126_E 3.115 1.00
93_R 127_A 3.072 1.00
141_T 154_I 2.995 1.00
201_G 310_I 2.992 1.00
35_G 41_I 2.914 1.00
66_E 72_A 2.799 1.00
312_Q 316_C 2.618 1.00
89_G 113_E 2.614 1.00
45_E 65_L 2.497 1.00
42_A 46_R 2.44 1.00
82_V 108_A 2.428 1.00
194_V 293_V 2.381 1.00
9_T 72_A 2.345 1.00
9_T 76_S 2.284 1.00
16_Y 146_L 2.278 1.00
138_S 188_V 2.235 1.00
22_I 60_P 2.227 1.00
266_M 271_M 2.217 1.00
68_D 71_T 2.177 1.00
142_F 251_L 2.166 1.00
272_D 275_S 2.136 1.00
271_M 279_K 2.1 1.00
149_G 176_S 2.075 1.00
274_Q 278_E 2.071 1.00
38_P 42_A 2.032 1.00
26_R 149_G 2.02 1.00
263_F 284_V 1.989 1.00
20_L 108_A 1.981 1.00
43_T 51_A 1.964 1.00
311_Y 315_Y 1.94 1.00
154_I 177_F 1.906 1.00
41_I 65_L 1.89 1.00
49_C 58_P 1.872 1.00
44_L 65_L 1.857 1.00
13_A 35_G 1.829 1.00
298_H 308_E 1.746 1.00
261_R 265_M 1.729 1.00
172_H 332_R 1.723 1.00
15_S 282_Q 1.722 1.00
191_G 244_A 1.711 1.00
158_S 164_A 1.705 1.00
294_R 311_Y 1.685 1.00
78_N 167_L 1.657 1.00
120_L 123_V 1.647 1.00
204_M 313_V 1.641 1.00
309_E 323_A 1.629 1.00
280_I 284_V 1.626 1.00
85_S 120_L 1.614 1.00
89_G 118_R 1.612 1.00
48_R 65_L 1.602 1.00
198_I 222_G 1.592 1.00
7_S 30_E 1.582 0.99
206_D 215_R 1.581 0.99
319_N 322_E 1.568 0.99
271_M 275_S 1.562 0.99
50_N 53_F 1.559 0.99
297_A 304_M 1.549 0.99
141_T 152_T 1.547 0.99
125_R 159_T 1.544 0.99
265_M 269_Q 1.537 0.99
25_A 63_L 1.529 0.99
73_L 95_I 1.525 0.99
290_T 310_I 1.518 0.99
59_F 63_L 1.499 0.99
318_K 323_A 1.499 0.99
23_T 177_F 1.486 0.99
20_L 80_L 1.478 0.99
206_D 261_R 1.474 0.99
145_E 213_N 1.466 0.99
78_N 170_L 1.465 0.99
43_T 47_D 1.458 0.99
73_L 79_I 1.458 0.99
229_L 296_L 1.451 0.99
161_Q 165_D 1.45 0.99
233_L 300_F 1.441 0.99
43_T 49_C 1.429 0.99
92_L 124_A 1.428 0.99
294_R 298_H 1.415 0.99
230_G 235_A 1.415 0.99
318_K 326_T 1.407 0.99
263_F 287_Y 1.405 0.98
135_A 163_F 1.394 0.98
227_S 231_A 1.393 0.98
229_L 233_L 1.392 0.98
208_I 320_A 1.386 0.98
219_I 250_V 1.382 0.98
208_I 321_R 1.379 0.98
262_R 281_G 1.376 0.98
142_F 257_Q 1.375 0.98
57_V 148_A 1.369 0.98
263_F 276_A 1.358 0.98
304_M 307_T 1.354 0.98
263_F 273_V 1.349 0.98
135_A 158_S 1.332 0.98
266_M 276_A 1.326 0.98
32_V 66_E 1.318 0.97
291_K 315_Y 1.304 0.97
291_K 316_C 1.294 0.97
13_A 33_L 1.293 0.97
66_E 71_T 1.29 0.97
294_R 307_T 1.283 0.97
45_E 48_R 1.275 0.97
223_L 246_L 1.267 0.97
303_E 330_R 1.25 0.96
58_P 61_D 1.244 0.96
38_P 67_S 1.226 0.96
183_P 236_D 1.226 0.96
88_F 120_L 1.224 0.96
57_V 147_A 1.222 0.96
276_A 280_I 1.221 0.96
273_V 287_Y 1.22 0.95
24_L 171_L 1.214 0.95
78_N 104_R 1.212 0.95
81_V 124_A 1.207 0.95
312_Q 318_K 1.201 0.95
26_R 176_S 1.2 0.95
118_R 122_D 1.196 0.95
30_E 64_H 1.188 0.95
124_A 134_L 1.187 0.95
144_K 257_Q 1.184 0.94
106_V 167_L 1.182 0.94
113_E 116_T 1.178 0.94
37_D 52_A 1.176 0.94
25_A 62_T 1.175 0.94
54_L 147_A 1.173 0.94
88_F 109_T 1.164 0.94
90_E 93_R 1.159 0.94
200_I 263_F 1.155 0.93
311_Y 316_C 1.155 0.93
39_E 42_A 1.149 0.93
104_R 163_F 1.141 0.93
156_L 167_L 1.139 0.93
32_V 75_A 1.134 0.93
85_S 289_N 1.127 0.92
90_E 94_Q 1.127 0.92
135_A 167_L 1.125 0.92
263_F 280_I 1.122 0.92
266_M 279_K 1.104 0.91
78_N 106_V 1.103 0.91
89_G 126_E 1.097 0.91
89_G 127_A 1.097 0.91
121_Q 134_L 1.089 0.91
262_R 266_M 1.089 0.91
75_A 100_R 1.077 0.90
294_R 308_E 1.077 0.90
275_S 279_K 1.074 0.90
70_A 98_L 1.074 0.90
40_H 44_L 1.069 0.89
27_N 174_G 1.061 0.89
198_I 226_M 1.054 0.89
144_K 148_A 1.054 0.89
44_L 59_F 1.045 0.88
150_L 214_A 1.043 0.88
154_I 179_V 1.043 0.88
212_A 255_D 1.042 0.88
36_H 87_V 1.039 0.88
77_R 102_D 1.034 0.87
48_R 61_D 1.031 0.87
291_K 295_E 1.03 0.87
117_G 299_R 1.029 0.87
89_G 123_V 1.028 0.87
169_Q 332_R 1.022 0.86
156_L 171_L 1.019 0.86
91_V 94_Q 1.016 0.86
251_L 256_N 1.014 0.86
224_A 228_R 1.011 0.86
212_A 257_Q 1.009 0.85
256_N 265_M 1.006 0.85
309_E 326_T 1.003 0.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3k96A20.97941000.518Contact Map0.787
4fgwA20.97351000.519Contact Map0.742
1evyA10.99711000.52Contact Map0.801
1yj8A30.97941000.525Contact Map0.772
1z82A20.96171000.547Contact Map0.817
1x0vA20.96461000.548Contact Map0.741
1txgA20.9441000.552Contact Map0.673
2p4qA10.8821000.648Contact Map0.382
1np3A40.87021000.648Contact Map0.252
2zydA20.8851000.657Contact Map0.42
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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