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OPENSEQ.org
ENO - Enolase
UniProt: P0A6P9 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10258
Length: 432 (429)
Sequences: 1907
Seq/Len: 4.45
ENO
Paralog alert: 0.08 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
329_E 333_K 4.891 1.00
12_I 36_A 3.735 1.00
101_E 325_K 3.73 1.00
271_E 303_Y 3.54 1.00
86_D 89_G 3.481 1.00
328_K 332_E 3.452 1.00
172_Q 244_A 3.452 1.00
11_E 58_R 3.341 1.00
74_P 105_K 3.242 1.00
338_S 365_T 3.234 1.00
358_M 362_A 3.113 1.00
23_A 113_A 3.052 1.00
278_E 307_V 2.957 1.00
269_T 272_E 2.931 1.00
69_A 73_G 2.885 1.00
153_I 226_I 2.871 1.00
217_G 221_E 2.826 1.00
189_V 241_I 2.82 1.00
220_A 283_Q 2.787 1.00
199_A 232_A 2.781 1.00
46_R 326_I 2.737 1.00
231_K 236_E 2.683 1.00
90_I 118_N 2.676 1.00
183_I 410_I 2.655 1.00
176_A 185_M 2.625 1.00
29_G 125_A 2.581 1.00
236_E 239_K 2.576 1.00
302_A 306_K 2.565 1.00
116_L 349_L 2.502 1.00
179_V 183_I 2.426 1.00
382_D 408_Q 2.396 1.00
408_Q 411_R 2.355 1.00
88_A 354_A 2.314 1.00
45_S 296_S 2.262 1.00
190_F 398_S 2.219 1.00
368_I 389_A 2.201 1.00
275_H 307_V 2.187 1.00
92_K 96_D 2.166 1.00
34_M 408_Q 2.162 1.00
274_T 303_Y 2.159 1.00
353_L 387_T 2.126 1.00
46_R 296_S 2.126 1.00
296_S 326_I 2.125 1.00
7_I 79_L 2.118 1.00
131_Y 415_A 2.089 1.00
179_V 410_I 2.074 1.00
320_F 330_G 2.058 1.00
223_L 227_A 2.009 1.00
327_L 339_I 2.004 1.00
73_G 77_Q 2.001 1.00
82_K 93_I 1.992 1.00
276_F 280_L 1.985 1.00
185_M 241_I 1.976 1.00
174_V 242_T 1.963 1.00
2_S 125_A 1.943 1.00
75_I 97_L 1.929 1.00
257_K 267_A 1.925 1.00
10_R 414_E 1.925 1.00
27_L 84_A 1.92 1.00
259_V 267_A 1.919 1.00
228_E 231_K 1.917 1.00
200_K 228_E 1.913 1.00
227_A 237_L 1.91 1.00
120_K 379_T 1.904 1.00
66_K 69_A 1.885 1.00
60_L 192_H 1.866 1.00
244_A 288_S 1.833 1.00
190_F 396_S 1.802 1.00
274_T 293_L 1.781 1.00
230_V 237_L 1.749 1.00
22_E 411_R 1.74 0.99
88_A 350_T 1.712 0.99
10_R 22_E 1.709 0.99
356_I 387_T 1.697 0.99
247_C 277_L 1.686 0.99
49_L 104_S 1.684 0.99
278_E 282_K 1.682 0.99
320_F 336_A 1.674 0.99
230_V 243_L 1.657 0.99
224_A 284_Y 1.655 0.99
24_E 34_M 1.65 0.99
299_D 333_K 1.645 0.99
279_E 283_Q 1.644 0.99
11_E 180_K 1.643 0.99
190_F 397_M 1.634 0.99
313_Q 391_Q 1.615 0.99
268_F 273_F 1.612 0.99
275_H 278_E 1.611 0.99
195_K 199_A 1.603 0.99
51_L 66_K 1.597 0.99
282_K 311_K 1.59 0.99
308_L 312_I 1.557 0.99
273_F 277_L 1.556 0.99
151_M 186_G 1.542 0.98
272_E 275_H 1.538 0.98
368_I 384_A 1.536 0.98
8_I 414_E 1.533 0.98
195_K 198_K 1.52 0.98
301_F 314_L 1.519 0.98
36_A 375_T 1.508 0.98
22_E 408_Q 1.506 0.98
45_S 250_S 1.477 0.98
292_G 314_L 1.468 0.98
134_I 386_G 1.462 0.98
328_K 358_M 1.41 0.97
302_A 335_I 1.404 0.97
177_K 185_M 1.398 0.97
270_S 300_G 1.39 0.96
242_T 287_V 1.389 0.96
194_A 212_Y 1.382 0.96
304_Q 314_L 1.371 0.96
75_I 106_F 1.352 0.96
111_I 348_S 1.349 0.96
400_S 403_V 1.342 0.95
181_E 184_R 1.34 0.95
357_K 361_D 1.329 0.95
150_M 172_Q 1.316 0.95
89_G 93_I 1.316 0.95
306_K 334_G 1.312 0.95
343_F 349_L 1.311 0.95
379_T 383_L 1.306 0.95
356_I 368_I 1.276 0.94
34_M 411_R 1.274 0.94
12_I 375_T 1.271 0.93
97_L 106_F 1.27 0.93
24_E 411_R 1.266 0.93
200_K 225_V 1.266 0.93
343_F 383_L 1.26 0.93
357_K 360_K 1.253 0.93
85_K 126_K 1.251 0.93
275_H 279_E 1.251 0.93
11_E 63_G 1.249 0.93
119_A 349_L 1.245 0.92
128_M 136_E 1.244 0.92
335_I 364_Y 1.236 0.92
281_T 308_L 1.22 0.91
74_P 77_Q 1.216 0.91
376_E 404_A 1.215 0.91
75_I 114_V 1.214 0.91
260_L 273_F 1.214 0.91
338_S 367_V 1.213 0.91
79_L 82_K 1.207 0.91
94_M 348_S 1.206 0.91
51_L 70_A 1.206 0.91
341_I 356_I 1.204 0.91
195_K 232_A 1.202 0.91
297_D 300_G 1.2 0.91
260_L 268_F 1.199 0.91
88_A 144_Y 1.199 0.91
37_A 113_A 1.194 0.90
154_I 164_V 1.194 0.90
10_R 24_E 1.194 0.90
423_N 427_E 1.187 0.90
271_E 275_H 1.186 0.90
23_A 71_V 1.178 0.89
220_A 224_A 1.176 0.89
70_A 74_P 1.171 0.89
100_T 105_K 1.17 0.89
88_A 92_K 1.169 0.89
169_F 222_A 1.165 0.89
142_G 354_A 1.162 0.89
134_I 353_L 1.16 0.89
13_I 59_F 1.159 0.88
292_G 304_Q 1.158 0.88
417_G 420_A 1.148 0.88
182_A 422_Y 1.143 0.88
304_Q 308_L 1.139 0.87
327_L 355_A 1.137 0.87
162_N 215_N 1.128 0.87
396_S 403_V 1.126 0.86
192_H 195_K 1.117 0.86
324_T 355_A 1.112 0.86
76_A 80_I 1.112 0.86
336_A 364_Y 1.112 0.86
353_L 383_L 1.109 0.85
178_T 181_E 1.108 0.85
274_T 307_V 1.107 0.85
184_R 188_E 1.106 0.85
334_G 364_Y 1.1 0.85
206_V 398_S 1.098 0.85
84_A 118_N 1.095 0.84
279_E 282_K 1.085 0.84
82_K 89_G 1.084 0.83
25_V 118_N 1.081 0.83
196_V 225_V 1.079 0.83
119_A 134_I 1.071 0.82
65_T 180_K 1.071 0.82
250_S 294_D 1.07 0.82
271_E 274_T 1.07 0.82
163_N 219_N 1.063 0.82
166_I 280_L 1.056 0.81
10_R 408_Q 1.056 0.81
185_M 235_Y 1.05 0.81
360_K 366_A 1.05 0.81
298_W 335_I 1.05 0.81
10_R 411_R 1.041 0.80
24_E 414_E 1.041 0.80
242_T 425_R 1.039 0.80
249_A 294_D 1.038 0.80
150_M 367_V 1.029 0.79
254_K 259_V 1.025 0.78
305_T 364_Y 1.025 0.78
281_T 312_I 1.024 0.78
120_K 378_A 1.021 0.78
220_A 279_E 1.013 0.77
22_E 34_M 1.006 0.77
93_I 96_D 1.003 0.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3otrA60.98381000.354Contact Map0.807
3uj2A80.97921000.359Contact Map0.812
1w6tA20.99071000.36Contact Map0.784
2akzA20.98151000.363Contact Map0.772
3tqpA20.98381000.372Contact Map0.801
2pa6A20.96761000.38Contact Map0.83
3qn3A40.95831000.406Contact Map0.797
2fymA40.99771000.408Contact Map0.755
2al1A20.97221000.421Contact Map0.744
3qtpA20.98381000.422Contact Map0.791
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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