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OPENSEQ.org
DER - GTPase Der
UniProt: P0A6P5 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14207
Length: 490 (449)
Sequences: 1505
Seq/Len: 3.35
DER
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
289_M 319_V 4.084 1.00
158_V 161_P 3.858 1.00
252_Y 369_R 3.4 1.00
86_L 116_V 3.364 1.00
208_V 309_I 3.036 1.00
91_A 117_A 3.026 1.00
250_R 369_R 2.92 1.00
206_A 285_A 2.794 1.00
246_E 251_E 2.736 1.00
221_R 358_G 2.705 1.00
309_I 316_L 2.602 1.00
207_I 219_T 2.549 1.00
260_V 278_T 2.532 1.00
67_V 71_M 2.526 1.00
246_E 249_G 2.493 1.00
441_Y 444_K 2.435 1.00
88_M 143_I 2.393 1.00
208_V 282_I 2.346 1.00
21_R 148_G 2.339 1.00
315_S 371_A 2.338 1.00
388_M 410_A 2.332 1.00
255_I 284_D 2.331 1.00
254_L 368_V 2.322 1.00
419_I 456_Q 2.289 1.00
5_V 159_L 2.271 1.00
365_F 368_V 2.263 1.00
100_E 134_S 2.237 1.00
91_A 120_T 2.23 1.00
5_V 45_A 2.115 1.00
115_L 140_I 2.102 1.00
5_V 84_V 2.082 1.00
317_V 371_A 2.082 1.00
435_K 457_F 2.075 1.00
18_L 145_A 2.05 1.00
40_R 74_Q 2.035 1.00
6_A 82_A 2.033 1.00
23_T 43_G 2.032 1.00
84_V 159_L 2.022 1.00
219_T 228_V 2.016 1.00
44_R 51_E 2.004 1.00
427_V 459_E 1.994 1.00
364_L 368_V 1.986 1.00
285_A 288_V 1.958 1.00
242_Y 284_D 1.883 0.99
419_I 454_R 1.844 0.99
86_L 159_L 1.834 0.99
23_T 27_D 1.814 0.99
290_L 306_L 1.813 0.99
335_K 339_D 1.799 0.99
205_L 368_V 1.792 0.99
303_L 341_R 1.786 0.99
42_Y 81_E 1.782 0.99
358_G 361_V 1.772 0.99
408_K 460_G 1.769 0.99
282_I 288_V 1.767 0.99
313_G 454_R 1.762 0.99
410_A 422_I 1.762 0.99
430_L 457_F 1.749 0.99
158_V 162_W 1.735 0.99
315_S 375_S 1.712 0.99
290_L 309_I 1.709 0.99
319_V 364_L 1.707 0.99
61_D 71_M 1.686 0.99
47_I 155_L 1.664 0.98
89_V 115_L 1.66 0.98
204_K 255_I 1.659 0.98
381_T 385_T 1.653 0.98
371_A 451_S 1.627 0.98
376_T 416_N 1.598 0.98
411_H 423_H 1.596 0.98
349_R 371_A 1.574 0.98
381_T 409_Y 1.566 0.97
218_L 353_I 1.561 0.97
28_A 41_K 1.539 0.97
332_E 336_E 1.535 0.97
46_E 49_G 1.526 0.97
319_V 353_I 1.524 0.97
283_E 312_S 1.521 0.97
407_L 422_I 1.511 0.97
391_A 438_L 1.507 0.97
410_A 420_V 1.49 0.96
306_L 345_I 1.485 0.96
22_L 45_A 1.469 0.96
84_V 114_F 1.468 0.96
205_L 254_L 1.463 0.96
374_S 447_D 1.454 0.96
121_D 149_R 1.437 0.95
282_I 309_I 1.436 0.95
377_R 447_D 1.43 0.95
240_S 281_A 1.424 0.95
261_R 271_E 1.417 0.95
137_L 140_I 1.417 0.95
317_V 351_H 1.403 0.94
320_V 352_F 1.391 0.94
79_I 109_R 1.39 0.94
319_V 351_H 1.385 0.94
351_H 367_S 1.378 0.94
336_E 340_F 1.376 0.94
31_A 36_L 1.375 0.94
141_Y 158_V 1.368 0.93
333_Q 337_T 1.362 0.93
377_R 448_V 1.36 0.93
114_F 141_Y 1.359 0.93
260_V 275_V 1.352 0.93
405_V 430_L 1.343 0.92
73_E 226_E 1.331 0.92
50_R 164_E 1.328 0.92
202_P 253_V 1.327 0.92
387_I 391_A 1.322 0.92
221_R 361_V 1.322 0.92
413_G 421_V 1.321 0.92
245_M 254_L 1.315 0.91
18_L 88_M 1.31 0.91
378_R 411_H 1.296 0.91
387_I 445_S 1.294 0.91
8_V 85_V 1.292 0.90
117_A 132_F 1.285 0.90
264_G 275_V 1.281 0.90
387_I 446_L 1.278 0.90
405_V 424_G 1.273 0.90
307_G 344_F 1.267 0.89
2_V 44_R 1.264 0.89
150_G 303_L 1.26 0.89
289_M 368_V 1.253 0.89
90_D 93_A 1.253 0.89
116_V 154_L 1.245 0.88
45_A 52_F 1.241 0.88
359_S 363_N 1.236 0.88
47_I 156_E 1.231 0.87
332_E 335_K 1.226 0.87
313_G 417_P 1.224 0.87
300_D 304_S 1.218 0.87
349_R 449_M 1.216 0.87
317_V 367_S 1.213 0.86
218_L 291_V 1.208 0.86
310_L 347_F 1.203 0.86
316_L 345_I 1.2 0.86
279_L 308_F 1.2 0.86
432_D 435_K 1.2 0.86
260_V 305_L 1.193 0.85
294_A 326_L 1.178 0.84
104_K 107_R 1.174 0.84
79_I 85_V 1.173 0.84
164_E 169_Q 1.163 0.83
114_F 158_V 1.159 0.83
95_L 131_D 1.159 0.83
370_E 447_D 1.154 0.82
244_P 253_V 1.153 0.82
266_I 275_V 1.152 0.82
231_Y 236_T 1.145 0.82
420_V 442_F 1.143 0.82
89_V 132_F 1.138 0.81
9_G 12_N 1.136 0.81
295_R 325_G 1.132 0.81
70_R 73_E 1.131 0.81
47_I 152_L 1.117 0.79
372_Y 376_T 1.117 0.79
285_A 384_L 1.114 0.79
290_L 318_I 1.106 0.79
379_V 448_V 1.103 0.78
307_G 311_N 1.101 0.78
40_R 78_A 1.099 0.78
273_F 277_K 1.099 0.78
203_I 250_R 1.088 0.77
117_A 138_G 1.088 0.77
261_R 301_Q 1.083 0.76
298_I 342_L 1.077 0.76
74_Q 78_A 1.072 0.75
446_L 450_G 1.065 0.75
129_V 142_P 1.062 0.74
95_L 134_S 1.06 0.74
207_I 228_V 1.058 0.74
4_V 53_I 1.057 0.74
5_V 254_L 1.054 0.74
22_L 54_C 1.052 0.73
61_D 68_E 1.048 0.73
27_D 43_G 1.045 0.73
351_H 364_L 1.044 0.73
442_F 446_L 1.04 0.72
349_R 370_E 1.04 0.72
152_L 156_E 1.04 0.72
26_R 283_E 1.038 0.72
422_I 457_F 1.038 0.72
5_V 116_V 1.038 0.72
218_L 361_V 1.037 0.72
424_G 427_V 1.035 0.72
9_G 13_V 1.033 0.72
426_Q 429_D 1.033 0.72
203_I 372_Y 1.031 0.71
383_M 386_R 1.03 0.71
252_Y 368_V 1.026 0.71
307_G 348_A 1.019 0.70
115_L 135_L 1.017 0.70
70_R 229_V 1.017 0.70
148_G 151_V 1.015 0.70
133_Y 320_V 1.013 0.69
120_T 149_R 1.003 0.68
9_G 14_G 1.002 0.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4dcuA10.88371000.343Contact Map0.664
1mkyA10.88161000.359Contact Map0.711
1egaA20.56531000.782Contact Map0.518
3ec1A20.70611000.796Contact Map0.283
3zvrA10.68371000.805Contact Map0.299
3h2yA10.7021000.811Contact Map0.336
3geeA10.79391000.813Contact Map0.478
1xzpA10.75921000.814Contact Map0.538
3ievA10.57761000.815Contact Map0.657
2yv5A10.5511000.816Contact Map0.275
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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