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OPENSEQ.org
DSBB - Disulfide bond formation protein B
UniProt: P0A6M2 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11393
Length: 176 (170)
Sequences: 458
Seq/Len: 2.69
DSBB
Paralog alert: 0.06 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
91_H 143_P 2.612 1.00
32_F 142_M 2.207 1.00
133_R 141_E 2.005 1.00
18_M 58_A 1.921 0.99
47_E 146_L 1.911 0.99
38_L 135_W 1.696 0.98
3_R 166_F 1.667 0.98
101_F 104_C 1.656 0.97
85_V 147_L 1.643 0.97
23_L 73_A 1.62 0.97
121_P 124_F 1.61 0.97
100_P 104_C 1.606 0.97
53_G 80_S 1.536 0.95
19_A 23_L 1.533 0.95
101_F 105_D 1.533 0.95
21_T 153_Y 1.514 0.95
47_E 88_T 1.511 0.95
61_G 142_M 1.493 0.95
32_F 36_M 1.491 0.94
92_T 96_L 1.486 0.94
107_M 110_F 1.483 0.94
46_Y 50_A 1.473 0.94
64_A 73_A 1.466 0.94
30_L 34_H 1.463 0.94
92_T 144_Q 1.458 0.94
120_V 123_V 1.455 0.93
23_L 55_L 1.433 0.93
126_A 129_D 1.418 0.92
140_L 144_Q 1.393 0.91
6_N 166_F 1.379 0.91
83_R 86_Q 1.363 0.90
26_E 52_F 1.323 0.88
129_D 143_P 1.29 0.87
89_Y 112_E 1.251 0.84
65_P 100_P 1.244 0.84
91_H 94_L 1.236 0.83
33_Q 116_L 1.232 0.83
155_I 159_L 1.215 0.82
56_G 60_I 1.21 0.81
50_A 87_L 1.209 0.81
30_L 116_L 1.203 0.81
89_Y 147_L 1.201 0.81
52_F 138_L 1.199 0.81
23_L 27_L 1.198 0.80
55_L 59_L 1.191 0.80
4_F 59_L 1.19 0.80
166_F 170_K 1.185 0.79
81_A 84_G 1.183 0.79
134_Q 141_E 1.183 0.79
22_A 55_L 1.183 0.79
105_D 108_V 1.177 0.79
57_A 80_S 1.176 0.79
5_L 159_L 1.154 0.77
95_Q 150_F 1.153 0.77
158_V 161_V 1.152 0.77
46_Y 111_P 1.151 0.77
33_Q 121_P 1.146 0.76
38_L 141_E 1.145 0.76
128_G 148_G 1.138 0.76
25_L 149_I 1.134 0.75
3_R 168_A 1.131 0.75
51_L 146_L 1.122 0.74
79_Y 83_R 1.119 0.74
13_G 78_L 1.116 0.74
45_I 103_T 1.115 0.73
16_L 59_L 1.111 0.73
32_F 88_T 1.11 0.73
90_E 126_A 1.11 0.73
16_L 62_A 1.092 0.71
43_L 94_L 1.087 0.71
6_N 9_S 1.076 0.70
2_L 6_N 1.075 0.69
49_C 125_V 1.074 0.69
4_F 168_A 1.063 0.68
99_S 104_C 1.063 0.68
119_W 124_F 1.056 0.68
129_D 137_F 1.05 0.67
142_M 149_I 1.047 0.67
166_F 169_K 1.041 0.66
50_A 53_G 1.037 0.65
9_S 163_S 1.036 0.65
99_S 103_T 1.035 0.65
108_V 111_P 1.033 0.65
128_G 137_F 1.032 0.65
131_A 137_F 1.029 0.65
56_G 68_P 1.015 0.63
2_L 167_K 1.011 0.63
129_D 135_W 1.008 0.62
25_L 142_M 1.006 0.62
19_A 58_A 1.006 0.62
167_K 170_K 1.005 0.62
61_G 64_A 1.005 0.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2hi7B111000.18Contact Map0.329
2l0lA10.1534970.86Contact Map0.221
2l0nA10.170595.50.878Contact Map0.283
3kp9A10.551122.90.941Contact Map0.64
2ks1B10.23866.80.953Contact Map0.145
2lzrA10.22736.40.954Contact Map0.046
2l16A10.2334.10.958Contact Map0.602
2vdaB10.15912.10.964Contact Map0
2jwaA20.238620.964Contact Map0.002
3m73A10.38071.50.967Contact Map0.446
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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