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OPENSEQ.org

KCY - Cytidylate kinase
UniProt: P0A6I0 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11265
Length: 227 (219)
Sequences: 1721
Seq/Len: 7.86

KCY
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
183_D 187_N 4.571 1.00
195_P 201_V 3.998 1.00
49_H 85_E 2.934 1.00
135_T 196_A 2.924 1.00
56_S 59_A 2.722 1.00
156_H 160_L 2.452 1.00
152_E 175_L 2.415 1.00
153_E 205_T 2.397 1.00
171_F 175_L 2.337 1.00
44_A 100_A 2.309 1.00
153_E 156_H 2.253 1.00
7_V 138_F 2.191 1.00
45_L 49_H 2.137 1.00
79_E 86_D 2.134 1.00
208_S 211_Q 2.1 1.00
143_V 219_Y 2.078 1.00
20_T 209_I 2.072 1.00
45_L 82_L 2.056 1.00
57_E 106_F 2.037 1.00
204_S 212_V 2.035 1.00
57_E 108_R 1.993 1.00
9_T 133_M 1.991 1.00
44_A 99_A 1.988 1.00
159_M 163_Q 1.985 1.00
121_R 138_F 1.965 1.00
46_A 83_E 1.917 1.00
207_L 215_K 1.884 1.00
146_F 186_R 1.883 1.00
176_A 180_E 1.828 1.00
48_L 96_V 1.824 1.00
180_E 184_R 1.805 1.00
25_M 216_A 1.768 1.00
94_Q 97_A 1.762 1.00
128_A 133_M 1.728 1.00
24_A 28_A 1.716 1.00
47_A 60_L 1.696 1.00
100_A 184_R 1.668 1.00
39_I 114_L 1.666 1.00
24_A 213_I 1.64 1.00
97_A 100_A 1.636 1.00
145_I 219_Y 1.633 1.00
34_L 128_A 1.624 1.00
61_V 108_R 1.616 1.00
21_L 213_I 1.594 1.00
215_K 218_Q 1.583 1.00
188_R 192_P 1.553 1.00
175_L 179_K 1.534 1.00
116_R 119_A 1.528 1.00
112_A 116_R 1.501 0.99
170_N 173_R 1.499 0.99
151_S 179_K 1.487 0.99
113_L 117_Q 1.475 0.99
48_L 99_A 1.443 0.99
38_A 91_I 1.42 0.99
176_A 179_K 1.408 0.99
29_L 217_L 1.401 0.99
180_E 183_D 1.398 0.99
115_R 119_A 1.381 0.99
107_P 111_E 1.375 0.99
143_V 220_A 1.374 0.99
31_W 125_G 1.374 0.99
145_I 216_A 1.369 0.99
25_M 213_I 1.354 0.99
45_L 87_V 1.34 0.99
68_D 83_E 1.339 0.99
62_P 66_H 1.338 0.99
135_T 194_V 1.311 0.98
115_R 118_R 1.305 0.98
160_L 163_Q 1.296 0.98
46_A 67_L 1.294 0.98
46_A 50_H 1.292 0.98
47_A 63_L 1.28 0.98
211_Q 214_E 1.256 0.98
151_S 175_L 1.242 0.97
25_M 217_L 1.242 0.97
107_P 190_V 1.217 0.97
136_V 191_A 1.215 0.97
147_L 204_S 1.204 0.97
82_L 87_V 1.184 0.96
21_L 216_A 1.183 0.96
214_E 218_Q 1.174 0.96
153_E 206_T 1.172 0.96
28_A 217_L 1.169 0.96
10_I 22_C 1.168 0.96
148_D 186_R 1.151 0.95
28_A 214_E 1.123 0.95
159_M 169_V 1.122 0.95
35_D 92_R 1.107 0.94
200_L 219_Y 1.106 0.94
161_Q 165_K 1.104 0.94
179_K 183_D 1.093 0.93
34_L 120_F 1.091 0.93
70_R 84_G 1.089 0.93
64_A 112_A 1.088 0.93
133_M 138_F 1.084 0.93
35_D 38_A 1.082 0.93
202_L 216_A 1.067 0.92
8_I 220_A 1.056 0.92
119_A 122_E 1.052 0.92
215_K 219_Y 1.048 0.91
39_I 113_L 1.034 0.91
29_L 221_R 1.027 0.90
114_L 191_A 1.027 0.90
98_N 177_E 1.02 0.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3r20A111000.497Contact Map0.751
1ckeA111000.5Contact Map0.788
4e22A111000.514Contact Map0.843
2h92A30.96041000.567Contact Map0.895
1q3tA10.98681000.571Contact Map0.6
3akeA10.91631000.579Contact Map0.759
1a7jA10.90311000.666Contact Map0.268
3fdiA20.832699.90.74Contact Map0.696
3hdtA20.885599.90.74Contact Map0.823
2grjA80.801899.80.755Contact Map0.651

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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