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OPENSEQ.org
HSLU - ATP-dependent protease ATPase subunit HslU
UniProt: P0A6H5 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11881
Length: 443 (443)
Sequences: 783
Seq/Len: 1.77
HSLU
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
375_R 426_S 4.886 1.00
216_L 224_L 4.389 1.00
40_L 48_V 3.812 1.00
342_R 346_E 3.481 1.00
337_T 378_E 3.399 1.00
99_I 253_V 3.389 1.00
22_N 333_Q 3.221 1.00
114_Q 246_A 3.15 1.00
375_R 378_E 3.053 1.00
169_D 222_M 3.044 1.00
128_E 164_R 2.992 1.00
365_N 417_N 2.984 1.00
131_I 173_I 2.943 1.00
341_E 374_K 2.872 1.00
100_I 253_V 2.798 1.00
217_K 220_D 2.641 1.00
336_T 339_D 2.597 1.00
161_K 165_E 2.56 1.00
162_K 167_Q 2.558 1.00
357_A 360_A 2.518 1.00
413_L 416_Q 2.481 1.00
107_A 247_V 2.473 1.00
360_A 365_N 2.453 1.00
115_A 242_D 2.336 1.00
14_D 21_D 2.252 1.00
285_V 326_L 2.224 0.99
367_E 417_N 2.208 0.99
81_V 255_I 2.16 0.99
115_A 118_K 2.14 0.99
289_T 296_M 2.139 0.99
100_I 247_V 2.087 0.99
134_V 173_I 2.032 0.99
421_D 427_K 2.01 0.99
337_T 374_K 1.969 0.98
8_E 11_S 1.953 0.98
157_Q 165_E 1.933 0.98
12_E 15_K 1.893 0.98
117_E 120_R 1.888 0.98
247_V 297_V 1.869 0.98
104_T 247_V 1.862 0.98
43_E 348_N 1.81 0.97
242_D 245_D 1.778 0.96
352_T 372_G 1.777 0.96
131_I 222_M 1.762 0.96
51_K 400_E 1.744 0.96
247_V 302_I 1.744 0.96
104_T 244_I 1.718 0.95
341_E 370_D 1.67 0.95
75_N 114_Q 1.657 0.94
366_I 420_I 1.656 0.94
371_S 422_A 1.633 0.94
155_A 159_F 1.594 0.93
423_D 426_S 1.593 0.93
7_R 412_D 1.582 0.92
245_D 249_Q 1.575 0.92
359_M 403_M 1.573 0.92
353_V 356_K 1.564 0.92
177_L 224_L 1.552 0.91
128_E 163_L 1.537 0.91
371_S 421_D 1.528 0.90
25_R 401_R 1.513 0.90
35_W 39_Q 1.512 0.90
405_E 409_D 1.504 0.89
104_T 297_V 1.503 0.89
379_A 398_V 1.502 0.89
123_A 127_A 1.496 0.89
386_S 436_E 1.49 0.89
163_L 168_L 1.475 0.88
367_E 419_T 1.466 0.88
128_E 160_R 1.463 0.88
11_S 121_Y 1.436 0.86
40_L 43_E 1.429 0.86
128_E 132_L 1.422 0.85
176_D 213_A 1.414 0.85
338_S 374_K 1.404 0.84
162_K 171_K 1.401 0.84
104_T 294_H 1.398 0.84
356_K 367_E 1.395 0.84
376_I 402_L 1.392 0.84
236_P 239_L 1.39 0.84
246_A 250_H 1.386 0.83
406_I 418_I 1.385 0.83
40_L 366_I 1.381 0.83
94_K 311_Q 1.347 0.81
341_E 373_I 1.334 0.80
79_I 247_V 1.329 0.80
352_T 366_I 1.323 0.79
169_D 219_K 1.32 0.79
360_A 363_G 1.32 0.79
111_V 246_A 1.292 0.77
239_L 350_S 1.276 0.76
79_I 255_I 1.266 0.75
159_F 162_K 1.265 0.75
160_R 164_R 1.259 0.74
131_I 134_V 1.258 0.74
275_E 412_D 1.248 0.74
107_A 244_I 1.246 0.73
383_V 398_V 1.246 0.73
127_A 226_I 1.243 0.73
158_A 162_K 1.236 0.72
347_P 396_H 1.227 0.72
43_E 48_V 1.21 0.70
185_E 188_A 1.206 0.70
25_R 404_E 1.198 0.69
136_I 158_A 1.187 0.68
113_V 117_E 1.185 0.68
268_S 373_I 1.174 0.67
249_Q 340_F 1.174 0.67
129_E 160_R 1.173 0.67
133_D 156_R 1.17 0.66
131_I 221_A 1.164 0.66
222_M 226_I 1.151 0.65
29_I 33_N 1.148 0.64
76_A 79_I 1.135 0.63
67_A 347_P 1.132 0.63
108_V 294_H 1.131 0.63
136_I 155_A 1.131 0.63
109_K 281_L 1.13 0.62
288_C 396_H 1.13 0.62
91_Y 272_V 1.128 0.62
46_H 72_K 1.126 0.62
124_E 226_I 1.125 0.62
127_A 222_M 1.124 0.62
163_L 169_D 1.12 0.61
42_E 45_R 1.117 0.61
289_T 300_D 1.113 0.61
104_T 108_V 1.11 0.60
284_L 288_C 1.108 0.60
345_T 370_D 1.105 0.60
155_A 171_K 1.101 0.60
105_D 294_H 1.1 0.59
54_L 84_T 1.084 0.58
247_V 296_M 1.08 0.57
130_R 229_E 1.079 0.57
112_R 236_P 1.079 0.57
18_I 413_L 1.079 0.57
399_L 402_L 1.075 0.57
100_I 104_T 1.066 0.56
426_S 430_D 1.064 0.56
307_S 361_T 1.061 0.55
92_V 272_V 1.057 0.55
84_T 138_P 1.051 0.54
173_I 217_K 1.05 0.54
112_R 212_K 1.05 0.54
72_K 248_E 1.05 0.54
85_K 94_K 1.049 0.54
44_L 349_A 1.049 0.54
29_I 120_R 1.048 0.54
235_N 238_E 1.044 0.53
289_T 298_K 1.044 0.53
362_E 415_G 1.04 0.53
337_T 375_R 1.04 0.53
366_I 403_M 1.036 0.53
35_W 281_L 1.036 0.53
155_A 158_A 1.036 0.53
352_T 373_I 1.035 0.52
378_E 382_Q 1.034 0.52
189_P 281_L 1.032 0.52
178_A 228_E 1.032 0.52
81_V 211_Q 1.031 0.52
154_A 158_A 1.03 0.52
198_Q 201_S 1.025 0.51
347_P 442_I 1.024 0.51
337_T 381_W 1.024 0.51
372_G 406_I 1.017 0.51
29_I 213_A 1.014 0.50
212_K 237_E 1.014 0.50
369_T 421_D 1.01 0.50
12_E 264_R 1.009 0.50
249_Q 376_I 1.008 0.50
217_K 406_I 1.007 0.49
15_K 48_V 1.007 0.49
262_C 312_I 1.007 0.49
284_L 307_S 1.007 0.49
176_D 211_Q 1.005 0.49
211_Q 430_D 1.003 0.49
235_N 307_S 1.003 0.49
124_E 131_I 1.002 0.49
29_I 404_E 1.002 0.49
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1g41A111000.509Contact Map0.459
1ofhA30.69981000.77Contact Map0.581
1um8A10.68621000.822Contact Map0.553
3hwsA60.6841000.852Contact Map0.485
1r6bX10.645699.90.875Contact Map0.492
3pxiA30.595999.90.885Contact Map0.537
1qvrA30.629899.90.896Contact Map0.554
2c9oA30.828499.80.9Contact Map0.465
4fcwA30.62399.80.902Contact Map0.582
3sylA20.620899.80.907Contact Map0.409
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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