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OPENSEQ.org
GLPQ - Glycerophosphoryl diester phosphodiesterase
UniProt: P09394 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10399
Length: 358 (329)
Sequences: 798
Seq/Len: 2.43
GLPQ
Paralog alert: 0.07 [within 20: 0.02] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
113_K 150_E 3.764 1.00
87_D 91_R 3.656 1.00
35_A 50_A 3.32 1.00
345_T 351_A 3.037 1.00
75_V 112_I 2.731 1.00
88_V 107_F 2.721 1.00
298_G 302_D 2.628 1.00
317_S 350_K 2.618 1.00
149_E 196_Y 2.56 1.00
42_Y 349_D 2.537 1.00
279_P 312_P 2.471 1.00
281_Y 330_L 2.454 1.00
76_V 151_E 2.395 1.00
169_Y 311_H 2.38 1.00
277_I 299_M 2.35 1.00
61_Y 167_G 2.101 1.00
234_Q 273_Y 2.085 1.00
69_T 112_I 2.069 1.00
40_S 50_A 2.038 0.99
149_E 195_K 2.036 0.99
55_Y 158_L 1.971 0.99
95_R 111_E 1.898 0.99
149_E 192_V 1.866 0.99
41_G 347_F 1.855 0.99
278_G 311_H 1.854 0.99
68_M 188_K 1.848 0.99
172_I 185_I 1.776 0.98
340_V 343_L 1.748 0.98
62_L 155_V 1.742 0.98
87_D 114_S 1.687 0.97
48_L 146_H 1.675 0.97
187_A 191_E 1.648 0.97
152_I 168_I 1.639 0.97
304_Q 341_N 1.618 0.96
264_P 302_D 1.611 0.96
56_A 158_L 1.607 0.96
270_V 274_A 1.594 0.96
169_Y 344_F 1.593 0.96
109_L 150_E 1.566 0.95
75_V 104_A 1.548 0.95
174_A 211_D 1.516 0.94
109_L 147_T 1.514 0.94
276_G 311_H 1.512 0.94
52_A 56_A 1.501 0.94
80_H 103_Y 1.498 0.94
317_S 347_F 1.49 0.93
169_Y 278_G 1.49 0.93
172_I 189_T 1.481 0.93
69_T 75_V 1.476 0.93
192_V 196_Y 1.469 0.93
153_E 196_Y 1.462 0.92
147_T 150_E 1.451 0.92
343_L 351_A 1.424 0.91
149_E 153_E 1.408 0.90
315_V 330_L 1.404 0.90
172_I 175_P 1.404 0.90
158_L 161_S 1.399 0.90
82_L 85_V 1.396 0.90
64_Q 76_V 1.358 0.88
331_Y 343_L 1.344 0.88
48_L 154_F 1.331 0.87
269_Q 272_E 1.33 0.87
315_V 334_L 1.326 0.87
172_I 214_E 1.304 0.85
205_V 230_L 1.295 0.85
113_K 144_R 1.29 0.84
37_R 45_E 1.287 0.84
209_C 214_E 1.283 0.84
187_A 221_E 1.267 0.83
315_V 335_Y 1.266 0.83
78_H 173_K 1.263 0.83
47_T 117_F 1.255 0.82
172_I 233_V 1.248 0.82
78_H 210_F 1.247 0.82
304_Q 310_V 1.241 0.81
331_Y 351_A 1.234 0.81
312_P 340_V 1.22 0.80
49_P 143_F 1.214 0.79
267_M 308_L 1.208 0.79
37_R 78_H 1.208 0.79
267_M 302_D 1.206 0.79
63_E 78_H 1.196 0.78
87_D 90_D 1.192 0.77
151_E 155_V 1.191 0.77
116_K 142_D 1.191 0.77
43_L 53_M 1.186 0.77
152_I 192_V 1.183 0.77
326_D 329_Q 1.182 0.77
39_A 54_A 1.171 0.76
173_K 210_F 1.168 0.75
105_I 178_H 1.165 0.75
172_I 218_I 1.164 0.75
157_G 161_S 1.164 0.75
277_I 310_V 1.164 0.75
206_Y 311_H 1.163 0.75
336_N 343_L 1.161 0.75
109_L 113_K 1.159 0.75
194_K 223_E 1.153 0.74
168_I 198_Y 1.152 0.74
236_I 270_V 1.152 0.74
66_L 148_F 1.148 0.74
210_F 235_L 1.147 0.74
172_I 209_C 1.139 0.73
91_R 114_S 1.138 0.73
278_G 313_Y 1.136 0.73
37_R 173_K 1.136 0.73
146_H 154_F 1.135 0.72
95_R 107_F 1.132 0.72
65_D 78_H 1.123 0.71
41_G 317_S 1.116 0.71
159_N 165_N 1.11 0.70
279_P 299_M 1.101 0.69
333_A 338_A 1.098 0.69
169_Y 276_G 1.095 0.69
169_Y 172_I 1.094 0.68
68_M 185_I 1.093 0.68
80_H 105_I 1.089 0.68
300_V 338_A 1.088 0.68
322_E 325_P 1.088 0.68
37_R 65_D 1.085 0.67
80_H 98_K 1.079 0.67
53_M 57_Q 1.074 0.66
312_P 315_V 1.07 0.66
78_H 235_L 1.067 0.66
187_A 217_R 1.063 0.65
68_M 74_L 1.062 0.65
74_L 189_T 1.061 0.65
297_T 300_V 1.06 0.65
129_V 133_P 1.059 0.65
262_F 277_I 1.059 0.65
311_H 342_G 1.048 0.64
37_R 63_E 1.046 0.63
52_A 158_L 1.045 0.63
235_L 344_F 1.043 0.63
80_H 101_R 1.043 0.63
35_A 260_W 1.035 0.62
81_Y 84_R 1.033 0.62
281_Y 315_V 1.031 0.62
89_A 93_P 1.03 0.62
45_E 171_E 1.028 0.61
68_M 73_N 1.023 0.61
171_E 210_F 1.022 0.61
65_D 173_K 1.021 0.61
42_Y 53_M 1.021 0.61
37_R 210_F 1.019 0.60
42_Y 57_Q 1.019 0.60
156_Q 196_Y 1.019 0.60
107_F 112_I 1.017 0.60
72_D 181_E 1.014 0.60
190_L 228_M 1.014 0.60
234_Q 261_M 1.013 0.60
78_H 171_E 1.01 0.59
303_A 310_V 1.008 0.59
233_V 276_G 1.007 0.59
93_P 102_Y 1.003 0.59
79_D 103_Y 1.002 0.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1ydyA20.99441000.295Contact Map0.71
2oogA60.76821000.491Contact Map0.711
3ch0A10.74021000.495Contact Map0.634
3l12A20.82961000.496Contact Map0.687
2pz0A20.70111000.508Contact Map0.696
2otdA40.68441000.516Contact Map0.627
3qvqA40.69831000.517Contact Map0.675
1zccA60.65641000.519Contact Map0.649
2o55A10.68721000.521Contact Map0.586
3ks6A40.68161000.525Contact Map0.593
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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